Bis{N-[5-(4-methoxy­phen­yl)-1,3,4-oxa­diazol-2-yl]ethanimidamidato}copper(II)

The title compound, [Cu(C11H11N4O2)2], was prepared by solvothermal synthesis using 2-amino-5-(4-methoxy­phen­yl)-1,3,4-oxadiazole and copper sulfate penta­hydrate in an acetonitrile solution. The CuII atom lies on an inversion center and is four-coordinated in a slightly distorted square-planar geometry by four N atoms of the ligands obtained from the formation of a bond between the amine N atom of the oxadiazole mol­ecule and the nitrile C atom of the solvent. In the crystal structure an inter­molecular N—H⋯N hydrogen bond links inversion-related mol­ecules

Comparative Electronic Properties of Two Arylene-Cyanovinylene Isomers and of Their Respective Electrogenerated Polymers.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).International audienceTwo arylene-cyanovinylene isomers formed by a phenyl unit substituted in para or meta positions by two cyanovinylene-methylthiophene were synthesized. Their main physicochemical properties were studied in order to point out the influence of the nature of the substitution (para vs meta) of the central phenyl unit on the electronic properties of the two isomers. The anodic electropolymerization of the two compounds was also studied with a main emphasis on the electrochemical behavior of the derived polymers showing that the specific behavior of the para-substituted isomer is maintained in its polymer leading to a polymer with a lower bandgap (1.95 eV) than the polymer obtained from the meta-substituted isomer (2.16 eV)

(E)-3-(2,6-Dichloro­phen­yl)-1-(4-methoxy­phen­yl)prop-2-en-1-one

In the title compound, C16H12Cl2O2, the dichloro­phenyl and methoxy­phenyl groups are linked by a prop-2-en-1-one group. The C=C double bond is trans configured. The mol­ecule is not planar, as can be seen from the dihedral angle of 6.21 (7)° between the planes of the two rings. The crystal structure can be described by two types of crossed layers which are parallel to (110) and (10)

Zwitterionic 1-{(E)-[(2-methylphenyl)iminiumyl]methyl}naphthalen-2-olate

The title Schiff base, C18H15NO, crystallizes in its zwitterionic form and an N—H...O hydrogen bond closes an S(6) ring. The dihedral angle between the aromatic ring systems is 36.91 (10)°. Weak aromatic π–π stacking occurs in the crystal [minimum centroid–centroid separation = 3.7771 (15) Å]

Hsp70-2 gene polymorphism: susceptibility implication in Tunisian patients with coronary artery disease

<p>Abstract</p> <p>Coronary artery disease (CAD) is a multifactorial disease where genetic and environmental factors interact in complex ways to cause the disease. Heat shock protein genes are involved in the progress of CAD. This implies that genetic variants of Hsp70–2 genes might contribute to the development of the CAD.</p> <p>Aim of study</p> <p>The aim of this study was to characterize statistical correlation of linkage between lipid profiles, polymorphism PstI site of Hsp70–2 gene and CAD.</p> <p>Patients and methods</p> <p>This study was carried out on Tunisian patients with CAD recruited from Hospital of Fattouma Bourguiba of Monastir-Tunisia. Polymerase chain reaction and restriction enzymes were used to determine the genotypic distributions in 252 unrelated patients and 151 healthy control subjects. Further, ApoA-I and ApoB as well as the serum total of cholesterol, HDL, triglyceride, and hs-CRP levels were measured.</p> <p>Results</p> <p>We showed a decreased level of ApoA-I, whereas the levels of each of ApoB and hs-CRP were increased in patients with CAD compared with control group. In addition our studies of a polymorphic PstI site of Hsp70-2 gene at position 1267 of the Hsp70–2 gene have revealed that the allelic frequency of P2 was significantly more frequent in CAD patients than controls group (p=0.007, OR=1.495). The genotypic distribution showed a high incidence of P2/P2 genotype in CAD patients (0.190) compared to healthy control (0.009) with reach significant difference (p=0.006). The P2 carriers showed a significantly increased of Total-Cholesterol (CT) and C-reactive protein (hs-CRP) levels in CAD patients (p=0.008 and p=0.018, respectively).</p> <p>Conclusion</p> <p>The high incidence of P2-Hsp70-2 genotype in CAD patients and the significantly association of P2/P2 genotype with elevated Total Cholesterol and hs-CRP levels, supported that P2–Hsp70–2 genotype has susceptibility implication in CAD and could increased the risk of CAD in Tunisian population.</p> <p>Virtual slides</p> <p>The virtual slide(s) for this article can be found here: <url>http://www.diagnosticpathology.diagnomx.eu/vs/1118340895703689</url></p