3,923 research outputs found
An Energy and Performance Exploration of Network-on-Chip Architectures
In this paper, we explore the designs of a circuit-switched router, a wormhole router, a quality-of-service (QoS) supporting virtual channel router and a speculative virtual channel router and accurately evaluate the energy-performance tradeoffs they offer. Power results from the designs placed and routed in a 90-nm CMOS process show that all the architectures dissipate significant idle state power. The additional energy required to route a packet through the router is then shown to be dominated by the data path. This leads to the key result that, if this trend continues, the use of more elaborate control can be justified and will not be immediately limited by the energy budget. A performance analysis also shows that dynamic resource allocation leads to the lowest network latencies, while static allocation may be used to meet QoS goals. Combining the power and performance figures then allows an energy-latency product to be calculated to judge the efficiency of each of the networks. The speculative virtual channel router was shown to have a very similar efficiency to the wormhole router, while providing a better performance, supporting its use for general purpose designs. Finally, area metrics are also presented to allow a comparison of implementation costs
The Case for a Heat-Pipe Phase of Planet Evolution on the Moon
The prevalence of anorthosite in the lunar highlands is generally attributed to the flotation of less dense plagioclase in the late stages of the solidification of the lunar magma ocean. It is not clear, however, that these models are capable of producing the extremely high plagioclase contents (near 100%) observed in both Apollo samples and remote sensing data, since a mostly solid lithosphere forms (at 60-70% solidification) before plagioclase feldspar reaches saturation (at approximately 80% solidification). Formation as a floating cumulate is made even more problematic by the near uniformity of the alkali composition of the plagioclase, even as the mafic phases record significant variations in Mg/(Mg+Fe) ratios. These problems can be resolved for the Moon if the plagioclase-rich crust is produced and refined through a widespread episode of heat-pipe magmatism rather than a process dominated by density-driven plagioclase flotation. Heat-pipes are an important feature of terrestrial planets at high heat flow, as illustrated by Io's present activity. Evidence for their operation early in Earth's history suggests that all terrestrial bodies should experience an early episode of heat-pipe cooling. As the Moon likely represents the most wellpreserved example of early planetary thermal evolution in our solar system, studies of the lunar surface and of lunar materials provide useful data to test the idea of a universal model of the way terrestrial bodies transition from a magma ocean state into subsequent single-plate, rigid-lid convection or plate tectonic phases
What are patients’ preferences for revision surgery after periprosthetic joint infection?:A discrete choice experiment
Why the lowest Landau level approximation works in strongly type II superconductors
Higher than the lowest Landau level contributions to magnetization and
specific heat of superconductors are calculated using Ginzburg - Landau
equations approach. Corrections to the excitation spectrum around solution of
these equations (treated perturbatively) are found. Due to symmetries of the
problem leading to numerous cancellations the range of validity of the LLL
approximation in mean field is much wider then a naive range and extends all
the way down to . Moreover the contribution of higher
Landau levels is significantly smaller compared to LLL than expected naively.
We show that like the LLL part the lattice excitation spectrum at small
quasimomenta is softer than that of usual acoustic phonons. This enhanses the
effect of fluctuations. The mean field calculation extends to third order,
while the fluctuation contribution due to HLL is to one loop. This complements
the earlier calculation of the LLL part to two loop order.Comment: 20 pages, Latex file, three figure
An exploratory randomised controlled trial of a premises-level intervention to reduce alcohol-related harm including violence in the United Kingdom
<b>Background</b><p></p>
To assess the feasibility of a randomised controlled trial of a licensed premises intervention to reduce severe intoxication and disorder; to establish effect sizes and identify appropriate approaches to the development and maintenance of a rigorous research design and intervention implementation.<p></p>
<b>Methods</b><p></p>
An exploratory two-armed parallel randomised controlled trial with a nested process evaluation. An audit of risk factors and a tailored action plan for high risk premises, with three month follow up audit and feedback. Thirty-two premises that had experienced at least one assault in the year prior to the intervention were recruited, match paired and randomly allocated to control or intervention group. Police violence data and data from a street survey of study premises’ customers, including measures of breath alcohol concentration and surveyor rated customer intoxication, were used to assess effect sizes for a future definitive trial. A nested process evaluation explored implementation barriers and the fidelity of the intervention with key stakeholders and senior staff in intervention premises using semi-structured interviews.<p></p>
<b>Results</b><p></p>
The process evaluation indicated implementation barriers and low fidelity, with a reluctance to implement the intervention and to submit to a formal risk audit. Power calculations suggest the intervention effect on violence and subjective intoxication would be raised to significance with a study size of 517 premises.<p></p>
<b>Conclusions</b><p></p>
It is methodologically feasible to conduct randomised controlled trials where licensed premises are the unit of allocation. However, lack of enthusiasm in senior premises staff indicates the need for intervention enforcement, rather than voluntary agreements, and on-going strategies to promote sustainability
An internet-based intervention with brief nurse support to manage obesity in primary care (POWeR+): a pragmatic, parallel-group, randomised controlled trial
Background
The obesity epidemic has major public health consequences. Expert dietetic and behavioural counselling with intensive follow-up is effective, but resource requirements severely restrict widespread implementation in primary care, where most patients are managed. We aimed to estimate the effectiveness and cost-effectiveness of an internet-based behavioural intervention (POWeR+) combined with brief practice nurse support in primary care.
Methods
We did this pragmatic, parallel-group, randomised controlled trial at 56 primary care practices in central and south England. Eligible adults aged 18 years or older with a BMI of 30 kg/m2 or more (or ≥28 kg/m2 with hypertension, hypercholesterolaemia, or diabetes) registered online with POWeR+—a 24 session, web-based, weight management intervention lasting 6 months. After registration, the website automatically randomly assigned patients (1:1:1), via computer-generated random numbers, to receive evidence-based dietetic advice to swap foods for similar, but healthier, choices and increase fruit and vegetable intake, in addition to 6 monthly nurse follow-up (control group); web-based intervention and face-to-face nurse support (POWeR+Face-to-face [POWeR+F]; up to seven nurse contacts over 6 months); or web-based intervention and remote nurse support (POWeR+Remote [POWeR+R]; up to five emails or brief phone calls over 6 months). Participants and investigators were masked to group allocation at the point of randomisation; masking of participants was not possible after randomisation. The primary outcome was weight loss averaged over 12 months. We did a secondary analysis of weight to measure maintenance of 5% weight loss at months 6 and 12. We modelled the cost-effectiveness of each intervention. We did analysis by intention to treat, with multiple imputation for missing data. This trial is registered as an International Standard Randomised Controlled Trial, number ISRCTN21244703.
Findings
Between Jan 30, 2013, and March 20, 2014, 818 participants were randomly assigned to the control group (n=279), the POWeR+F group (n=269), or the POWeR+R group (n=270). Weight loss averaged over 12 months was recorded in 666 (81%) participants. The control group lost almost 3 kg over 12 months (crude mean weight: baseline 104·38 kg [SD 21·11; n=279], 6 months 101·91 kg [19·35; n=136], 12 months 101·74 kg [19·57; n=227]). The primary imputed analysis showed that compared with the control group, patients in the POWeR+F group achieved an additional weight reduction of 1·5 kg (95% CI 0·6–2·4; p=0·001) averaged over 12 months, and patients in the POWeR+R group achieved an additional 1·3 kg (0·34–2·2; p=0·007). 21% of patients in the control group had maintained a clinically important 5% weight reduction at month 12, compared with 29% of patients in the POWeR+F group (risk ratio 1·56, 0·96–2·51; p=0·070) and 32% of patients in the POWeR+R group (1·82, 1·31–2·74; p=0·004). The incremental overall cost to the health service per kg weight lost with the POWeR+ interventions versus the control strategy was £18 (95% CI −129 to 195) for POWeR+F and –£25 (−268 to 157) for POWeR+R; the probability of being cost-effective at a threshold of £100 per kg lost was 88% and 98%, respectively. No adverse events were reported.
Interpretation
Weight loss can be maintained in some individuals by use of novel written material with occasional brief nurse follow-up. However, more people can maintain clinically important weight reductions with a web-based behavioural program and brief remote follow-up, with no increase in health service costs. Future research should assess the extent to which clinically important weight loss can be maintained beyond 1 year
Linking dwarf galaxies to halo building blocks with the most metal-poor star in Sculptor
Current cosmological models indicate that the Milky Way's stellar halo was
assembled from many smaller systems. Based on the apparent absence of the most
metal-poor stars in present-day dwarf galaxies, recent studies claimed that the
true Galactic building blocks must have been vastly different from the
surviving dwarfs. The discovery of an extremely iron-poor star (S1020549) in
the Sculptor dwarf galaxy based on a medium-resolution spectrum cast some doubt
on this conclusion. However, verification of the iron-deficiency and
measurements of additional elements, such as the alpha-element Mg, are
mandatory for demonstrating that the same type of stars produced the metals
found in dwarf galaxies and the Galactic halo. Only then can dwarf galaxy stars
be conclusively linked to early stellar halo assembly. Here we report
high-resolution spectroscopic abundances for 11 elements in S1020549,
confirming the iron abundance of less than 1/4000th that of the Sun, and
showing that the overall abundance pattern mirrors that seen in low-metallicity
halo stars, including the alpha-elements. Such chemical similarity indicates
that the systems destroyed to form the halo billions of years ago were not
fundamentally different from the progenitors of present-day dwarfs, and
suggests that the early chemical enrichment of all galaxies may be nearly
identical.Comment: 16 pages, including 2 figures. Accepted for publication in Nature. It
is embargoed for discussion in the press until formal publication in Natur
Near Horizon Limits of Massless BTZ and Their CFT Duals
We consider the massless BTZ black hole and show that it is possible to take
its "near horizon" limit in two distinct ways. The first one leads to a null
self-dual orbifold of AdS3 and the second to a spacelike singular AdS3/Z_K
orbifold in the large K limit, the "pinching orbifold". We show that from the
dual 2d CFT viewpoint, the null orbifold corresponds to the p^+=0 sector of the
Discrete Light-Cone Quantisation (DLCQ) of the 2d CFT where a chiral sector of
the CFT is decoupled, while the pinching orbifold corresponds to taking an
infinite mass gap limit in both the right and left sectors of the 2d CFT,
essentially leaving us with the states L_0=\bar L_0=c/24 only. In the latter
case, one can combine the near horizon limit with sending the 3d Planck length
l_P to zero, or equivalently the dual CFT central charge c to infinity. We
provide preliminary evidence that in that case some nontrivial dynamics may
survive the limit.Comment: 22 pages, no figures, v2: minor improvements, references adde
A theoretical investigation of the low lying electronic structure of poly(p-phenylene vinylene)
The two-state molecular orbital model of the one-dimensional phenyl-based
semiconductors is applied to poly(p-phenylene vinylene). The energies of the
low-lying excited states are calculated using the density matrix
renormalization group method. Calculations of both the exciton size and the
charge gap show that there are both Bu and Ag excitonic levels below the band
threshold. The energy of the 1Bu exciton extrapolates to 2.60 eV in the limit
of infinite polymers, while the energy of the 2Ag exciton extrapolates to 2.94
eV. The calculated binding energy of the 1Bu exciton is 0.9 eV for a 13
phenylene unit chain and 0.6 eV for an infinite polymer. This is expected to
decrease due to solvation effects. The lowest triplet state is calculated to be
at ca. 1.6 eV, with the triplet-triplet gap being ca. 1.6 eV. A comparison
between theory, and two-photon absorption and electroabsorption is made,
leading to a consistent picture of the essential states responsible for most of
the third-order nonlinear optical properties. An interpretation of the
experimental nonlinear optical spectroscopies suggests an energy difference of
ca. 0.4 eV between the vertical energy and ca. 0.8 eV between the relaxed
energy, of the 1Bu exciton and the band gap, respectively.Comment: LaTeX, 19 pages, 7 eps figures included using epsf. To appear in
Physical Review B, 199
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