THE ROLE OF PROSTAGLANDIN (PGE2) IN ALVEOLAR BONE DESTRUCTION

Inflammation chronic diseases in gingiva and periodontium tissue cause destruction of alveolar bone. Periodontopathy bacteria cause periodontal tissue destruction by host cell activating system, such as prostaglandin. PGE2 induce bone resorption and MMP secretion (Academic report, 1999). Prostaglandin E2 (PGE2) is formed as a result of the metabolism of arachidonic acid. It participates in inflammatory response. Prostaglandin cause alveolar bone destruction by osteoclast activating. Beside it, it enhance calcium metabolism

EFFECT AMOUNT OF CIGARETTE SMOKING ON GINGIVAL EPITHELIUM THICKNESS : EFEK JUMLAH ROKOK SIGARET TERHADAP KETEBALAN EPITHEL GINGIVAL

Smoking is one of the most important risk factors for oral diseases. Tobacco smoking produces more than 4000 chemical materials. Gingival protects underlying tissue to oral environment. Cells of gingival epithelium are metabolic actively, and can be reacted to internal and external stimuli. The thickness of oral mucosa epithelium is related with the amount of cell or proliferation activity. This study aimed to investigate effect amount of cigarette smoking on thickness of gingival epithelium. This study was animal experimental laboratory study. This study used 40 males Rattus Norvegicus strain Spraque Dawley, and were divided into 4 groups. They were control, mild, moderate and severe smoker groups. The animal models were exposed 2 grams by pump and were euthanized with ketamine in the 7th day. Measurement of gingival epithelium thickness used hematoxylin eosin that was measured from basale to granular layer and 3 sites (in µm). Data were analyzed by one way anova. The results of this research showed that there was an increasing thickness of gingival epithelium of animal models. The highest of gingival epithelium thickness was in severe smoker groups. In conclusion, cigarette smoking influenced on gingival epithelium thickness

EFFECT OF SEVERITY SMOKING ON THICKNESS OF GINGIVAL EPITHELIUM

Smoking is one of the most important risk factor for oral diseases. Gingival protects underlying tissue. The thickness of oral mucosa epithelium is related with the amount of cell or proliferation activity. This study was aimed to investigate effect of severity smoking on thickness of gingival epithelium. This study used males Rattus Norvegicus strain Spraque Dawley, and were divided in 4 groups. They were control, mild, moderate and severe smoker. The animal models were euthanized with ketamine in the 12th day. Gingival epithelium thickness was measured from basale layer to granular layer in 3 sites. The results were analyzed by one way anova. The result of this research showed there was increasing thickness of gingival epithelium of animal models. The conclusion of this study showed that severity smoker influenced the gingival epithelium thickness.</p

Effect Amount of Cigarette Smoking on Gingival Epithelium Thickness

Smoking is one of the most important risk factors f or oral diseases. Tobacco smoking produces more tha n 4000 chemical materials. Gingival protects underlying tissue to oral environment. Cells of gingival epithelium are metabolic actively, and can be reacted to internal and external stimuli. The thickness of oral mucosa epithelium is related with the amount of cell or proliferation activity. This study aimed to investigate effect amount of cigarette smoking on thickness of gingival epithelium. This study was animal experimental laboratory study. This study used 40 males Rattus Norvegicus strain Spraque Dawley , and were divided into 4 groups. They were control , mild, moderate and severe smoker groups. The animal models were exposed 2 grams by pump and were euthanized with ketamine in the 7th day. Measurement of gingival epithelium thickness used hematoxylin eosin that was measured from basale to granular layer and 3 sites (in μm). Data were analyzed by one way anova. The results of this research showed that there was an increasing thickness of gingival epithelium of animal models. The highest of gingival epithelium thickness was in severe smoker groups. In conclusion, cigarette smoking influenced on gingival epithelium thickness