Probing the Spatial-temporal Properties of the Nuclear Pore Complex

13301甲第4841号博士（学術）金沢大学博士論文要旨Abstract 要約Outline 以下に掲載：ACS Nano 11(6) pp.5567-5578 2017. American Chemical Society. 共著者：Mohamed MS, Kobayashi A, Taoka A, Watanabe-Nakayama T, Kikuchi Y, Hazawa M, Minamoto T, Fukumori Y, Kodera N, Uchihashi T, Ando T, Wong R

The effectiveness of designing Egyptian smart government applications during the Corona virus pandemic

Abstract: The successive developments in the field of digital technology caused a great revolution in the different field of life, including the field of government services, hence the great and continuous development in technologies, many new applications of information and communication technology have appeared, resulted in great change in our life and helping in changing the way citizens deal with government services, and made The process of communication better, quicker, more accurate, quality, fast, easy and to cheaper, so that the Egyptian citizen becomes a basic partner in the government institution, and with the Corona virus invading the barriers of time and place, as many countries around the world were forced to close completely, which caused to the disruption of citizen services.A Then comes, The role of smart government's applications in order to make the best use of information and communication technology to build a sustainable environment and encouraging the use of technology to help the Egyptian citizens to benefit these services, the smart government is not a new technical challenge as much as it is atrial to benefit from the technical achievements in the field of government institutions to confront the problems of traditional government institutions, The smart government is the last stage in the transformation from the traditional government, passing by the electronic-government to building an integrated smart government, and this stage cannot be achieved suddenly or quickly, but with stable and carefully studied steps with a gradual development and strategic change in the Egyptian government that leads to a radical shift in the methods of communication between the government and the Egyptian citizen during the spread of the global Corona epidemic ... The research is summarized in studying the digital transformation of institutions and applying it to the Egyptian government institutions and benefiting from its advantage in designing a smart Egyptian government, setting points for its construction requirements, its characteristics, and its objectives, it will also help in setting functional and design considerations for smart applications for Egyptian government institutions... The research ends with an analytical study of two models of smart applications confronting Corona virus:- The Health Egypt application (Egypt)- Tawakkalna application (Saudi Arabia

The Effectiveness of Digital Marketing in promoting the digital services of Egyptian government institutions

In our time especially with the fast spreading of technology and social media, many people spend a very long-time browsing web, YouTube, and social media, such times have been increased in the last two years, especially after the Corona epidemic, and the curfew. That’s why 2020 was a central year in enhancing the digital means, after the quick increases in digital means in many of the institutions as a result of the spread of the epidemic, so they resort to using the digital means in marketing planning for investments, many institutions concentrate on the stations of the contact through the internet, as they can't ignore the digital technology and at sometimes the human conduct's changes (as regards the use of the social media) which give good chances to establish digital markets for the institutions, despite the progress achieved by the digital means in the latest years, and the development of many digital means to be a strategy of better marketing for the institutions, a belief that the digital marketing is directed only to the private institutions and has nothing to do with the government institutions is wrong as any institutions can use the digital marketing and achieve a positive reward of investment through their campaign of digital marketing directed to audience, on condition that such a strategy must be adapted to achieve benefits for the comprehensive marketing strategy of the institutions.Digital marketing as a strategy has great importance for the governmental institutions which developed their strategies for digital change.The quick digital change high lightened many disadvantages in the traditional marketing of the governmental institution's services at the sometimes, for the changes of the audience behavior it helps to their expectations and meet their different natures and desires, it also helps to change channels to introduce the correct type of services, to achieve constant development and to guarantee competitive advantage and a good mental image, thus the governmental institutions confront numerous challenges including the increasing competition which spotlights the method of using the digital marketing for supporting the governmental services. Research is summarized in studying the effectiveness of digital marketing of institutions and applying it to Egyptian government institutions and its benefits in marketing digital government services via the Internet and social media. The research ends with the analytical study of a model of digital marketing for government services in the advertising campaign for the Egyptian Tax Authority

Portal Venous Pressure as a Predictor of Mortality in Child’s A Cirrhotic Patients Undergoing Elective Surgery: A Prospective Study

BACKGROUND: Recently, portal venous pressure (PVP) exhibited high sensitivity and specificity in anticipating death in cirrhotic cases submitted to emergency operations. AIM: The current prospective work aimed to evaluate the utility of PVP in predicting 1st month post-operative death in Child’s A cirrhotic cases who underwent elective operations. METHODS: One-hundred and twenty cirrhotic cases that were planned to undergo elective surgery were enrolled in the current prospective work. The intraoperative (I.O) PVP and central venous pressure (CVP) were measured. The statistical analysis was performed using the SPSS version 22.0. The receiver operative curve was plotted to measure the predictive value of PVP. Multivariate analysis was done using logistic regression method for the significant variables impacting mortality on univariate analysis. RESULTS: Twenty-nine patients died in the current work. Patients who survived had statistically considerably lower PVP than patients who died (8.2 ± 1.5 vs. 12.5 ± 1.6 mmHg, respectively, p < 0.001). Similarly, patients who died had significantly higher I.O CVP (p < 0.001), body mass index (p < 0.001), and were more likely to have model for end-stage liver disease score between 9 and 16 (p = 0.003). At a cutoff value ≥10.5 mmHg, the PVP had a sensitivity of 82.8% and specificity of 93.4% for the prediction of mortality. The logistic regression analysis showed that only PVP (odds ratio [OR] =3.1, 95% confidence interval [CI] 1.25–7.5) and CVP (OR = 2.8, 95% CI 1.2–6.5) were the only independent predictors of mortality. CONCLUSION: PVP is a significant predictor of death in Child’s A cirrhotic cases submitted to elective operations

Non-Invasive Panel for Prediction of Large Esophageal Varices in Patients with HCV-Related Cirrhosis after DAAS Therapy

To study sonographic and laboratory parameters as diagnostic non-invasive Indices for prediction and screening of large varices in liver cirrhotic patients post hepatitis C virus after direct Actin antiviral drugs (DAAS). Introduction: All cirrhotic patients should be screened for esophageal varices (EV) via endoscopy, as recommended by the guidelines. However, repeated endoscopy is not well accepted by patients and is a costly procedure that places a heavy burden on the endoscopic unit. Therefore, noninvasive predictors of EVs and size discrimination for EVs are of particular importance.After dividing DAAS into three arms: arm 1 with Non-EV, arm 2grad1&2 EV (Small Vriceal arm), and arm 3 grade 3&4 EV (Large Variceal arm). medical history, physical examination, standard laboratory tests, abdominal ultrasound, and sonographic parameters such as portal vein velocity (PVV). Splenic Index (SI) Splenoportal Index (SPI), platelet count/spleen diameter ratio (PCSDR) and upper gastrointestinal endoscopy were performed for all participants.Results: The Noninvasive sonographic and laboratory parameters for prediction of the presence of EVs have demonstrated that low platelet count/spleen diameter ratio (PC/SD) at cut-off (CO) ≤ 1121.43 cu/mm, then high SPI at CO >3.98 cm /sec then high FIB4 at CO > 2.68 then high APRI at CO > 0.6 then PVV at CO ≤ 22.2 cm/sec then high SI at CO > 89.7 and lastly Child’s – Pugh’s score at CO > 6 respectively.. The Non Invasive sonographic and laboratory parameters for discrimination of the size of EVs showed that high SPI was found to be the most accurate parameter at CO less than >7.75 cm/sec Then low PC/SD at CO ≤ 514.08 cu/mm then high APRI at CO > 1.4 then high FIB4 at CO > 7,6 then high SI with AUC 0.821 at CO > 122.4 then low PVV at CO < 15 and lastly Child’s –Pugh’s score at CO> 6 respectively.Conclusions: The sonographic and laboratory indices are non- invasive parameters for the prediction of EV & discrimination of its size. And to determine when Upper Endoscopy is done for liver cirrhotic patients post-C after DAA

2-(1,3-Benzothia­zol-2-yl)guanidinium chloride

The non-H atoms of the cation of the title salt, C8H9N4S+·Cl−, are approximately co-planar (r.m.s. deviation = 0.037 Å), with one amino group forming an intra­molecular hydrogen bond to the tertiary N atom of the benzothia­zole fused-ring system. The cations and anions are linked by cyclic R 2 1(6) N—H⋯Cl hydrogen-bonding associations, generating helical chains running along the b-axis direction

N-(4,6-Dimethyl­pyrimidin-2-yl)-1,3-benzothia­zol-2-amine

In the title compound, C13H12N4S, an amino N atom is connected to a 1,3-benzothia­zole fused-ring system and a dimethyl-substituted pyrimidine ring, these components being aligned [inter­planar dihedral angle = 1.9 (1)°]. The secondary amino N atom forms an inter­molecular N—H⋯N hydrogen bond to an N atom of the fused ring of an adjacent mol­ecule, generating a centrosymmetric cyclic hydrogen-bonded dimer [graph set R 2 2(8)]

2-(1,3-Benzoxazol-2-yl)guanidinium chloride

The non-H atoms of the cation of the title salt, C8H9N4O+·Cl−, are approximately co-planar (r.m.s. deviation = 0.024 Å) with one amino group forming an intra­molecular hydrogen bond to the tertiary N atom of the benzoxazole fused-ring system. The cations and anions are linked by cyclic R 2 1(6) N—H⋯Cl hydrogen-bonding associations, generating linear chains running along the a-axis direction

Proposed model for strength analysis of HSC eccentrically loaded slender columns

A model for the strength analysis of high-strength concrete (HSC) columns subjected to eccentric loading is proposed. The model is based on a stability analysis of pin-ended columns using the theoretical sinusoidal equation for the deflected shape of the column. The reduction in column stiffness as the axial load increases, representing the basic characteristic of the inelastic response of columns, is considered subject to equilibrium conditions, compatibility requirements, and constitutive relationships for the concrete and reinforcement. The tension-stiffening effect was taken into consideration. The column integrity is limited by either the material or the instability mode of failure. The method was applied to a wide range of experimental data and was compared with the Egyptian, European, and American building codes of practice. The ultimate strength predicted by the proposed model showed excellent agreement with the test results and was in good agreement with the codes of practice. The mean predicted-to-experimental ultimate load ratio was 0·94, with a coefficient of variation of 10·8%

Strength of eccentrically loaded slender columns made with high-strength concrete

A non-linear finite-element analysis model was developed to predict the strength analysis of high- strength-concrete slender columns. The studied parameters were compressive strength, load eccentricity, slenderness ratio, longitudinal and transverse reinforcement ratio. The model results were verified by comparison with analytical results and experimental results in literature. A parametric study was also carried out by comparing the model results with those obtained using design codes, which were predominantly based on data derived from tests on normal-strength concrete. The model proved to be a suitable tool for the strength analysis of slender high-strength-concrete columns. ACI-318-14 gave the most conservative predictions of the load-carrying capacity of centrally loaded columns but was close to the model results for eccentric loading. The procedures specified by BS EN 1992-1-1:2004 Eurocode 2 resulted in a significant under-estimation of the load-carrying capacity of slender columns, particularly for eccentric loading, and this increases with greater slenderness ratios. This is probably because the confinement index taken into consideration in the software was not consistent, ranging from 0.03% to 5.14%. It was concluded that special clauses need to be introduced in design codes for the accurate design of high-strength-concrete columns