Convenient one-pot formation of highly functionalized 5-bromo-2-aminothiazoles, potential endocannabinoid hydrolase MAGL inhibitors

Highly functionalized 5-bromo-2-amino-1,3-thiazoles bearing various substituents could be easily prepared by a rapid and efficient one-pot method, using simple starting materials and mild conditions while avoiding the use of metal catalysts or inconvenient reagents such as elemental halogens. These useful products can serve as starting materials for other reactions or as pharmacologically interesting compounds. In our work we have shown that the resulting 5-bromothiazole compounds could lead to monoacylglycerol lipase (MAGL) inhibition in the lM range

A Short Reflection on COVID-19 and Gender Equality in Healthcare

The current short reflection aims to investigate the topic relating to healthcare governance, dur-ing the Covid-19 pandemic, through the analysis of literature and the study of a case. The CA-OS approach allows to map the characteristics of the analyzed Institution and the role of wom-en in a highly multidisciplinary healthcare and research context

CCDC 1851262: Experimental Crystal Structure Determination

Related Article: Julien R.C. Prevost, Arina Kozlova, Bouazza Es Saadi, Esra Yildiz, Sara Modaffari, Didier M. Lambert, Lionel Pochet, Johan Wouters, Eduard Dolušić, Raphaël Frédérick|2018|Tetrahedron Lett.|59|4315|doi:10.1016/j.tetlet.2018.10.055,An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.