3,757 research outputs found
Different approaches to calculate the decay width
The rare decay, currently under analysis by the
NA48/2 Collaboration, is considered. We have performed two theoretical
approaches to calculate the differential decay width -- in the kaon rest frame,
where we use Cabibbo-Maksimovicz variables, and in the center-of-mass system of
the lepton pair. The latter essentially simplifies the computations. A
comparison between the two approaches has been performed. We have also found
the dependencies of the differential decay rate as a function of the virtual
photon and dipion system massesComment: 10 pages,5 figure
JNK signaling: Regulation and functions based on complex protein-protein partnerships
The c-Jun N-terminal kinases (JNKs), as members of the mitogenactivated protein kinase (MAPK) family, mediate eukaryotic cell responses to a wide range of abiotic and biotic stress insults. JNKs also regulate important physiological processes, including neuronal functions, immunological actions, and embryonic development, via their impact on gene expression, cytoskeletal protein dynamics, and cell death/survival pathways. Although the JNK pathway has been under study for -20 years, its complexity is still perplexing, with multiple protein partners of JNKs underlying the diversity of actions. Here we review the current knowledge of JNK structure and isoforms as well as the partnerships of JNKs with a range of intracellular proteins. Many of these proteins are direct substrates of the JNKs. We analyzed almost 100 of these target proteins in detail within a framework of their classification based on their regulation by JNKs. Examples of these JNK substrates include a diverse assortment of nuclear transcription factors (Jun, ATF2, Myc, Elk1), cytoplasmic proteins involved in cytoskeleton regulation (DCX, Tau, WDR62) or vesicular transport (JIP1, JIP3), cell membrane receptors (BMPR2), and mitochondrial proteins (Mcl1, Bim). In addition, because upstream signaling components impact JNK activity, we critically assessed the involvement of signaling scaffolds and the roles of feedback mechanisms in the JNK pathway. Despite a clarification of many regulatory events in JNK-dependent signaling during the past decade, many other structural and mechanistic insights are just beginning to be revealed. These advances open new opportunities to understand the role of JNK signaling in diverse physiological and pathophysiological states. Copyright © 2016, American Society for Microbiology. All Rights Reserved
ChPT tests at the NA48 and NA62 experiments at CERN
The NA48/2 Collaboration at CERN has accumulated unprecedented statistics of
rare kaon decays in the Ke4 modes: Ke4(+-) ()
and Ke4(00) () with nearly one percent
background contamination. The detailed study of form factors and branching
rates, based on these data, has been completed recently. The results brings new
inputs to low energy strong interactions description and tests of Chiral
Perturbation Theory (ChPT) and lattice QCD calculations. In particular, new
data support the ChPT prediction for a cusp in the invariant mass
spectrum at the two charged pions threshold for Ke4(00) decay. New final
results from an analysis of about 400 rare
decay candidates collected by the NA48/2 and NA62 experiments at CERN during
low intensity runs with minimum bias trigger configurations are presented. The
results include a model-independent decay rate measurement and fits to ChPT
description.Comment: XIIth International Conference on Heavy Quarks and Leptons 2014,
Mainz, German
Recent NA48/2 and NA62 results
The NA48/2 Collaboration at CERN has accumulated and analysed unprecedented
statistics of rare kaon decays in the modes: () and ()
with nearly one percent background contamination. It leads to the improved
measurement of branching fractions and detailed form factor studies. New final
results from the analysis of 381 rare decay
candidates collected by the NA48/2 and NA62 experiments at CERN are presented.
The results include a decay rate measurement and fits to Chiral Perturbation
Theory (ChPT) description.Comment: Prepared for the Proceedings of "Moriond QCD and High Energy
Interactions. March 22-29 2014." conferenc
Developing additional competition classes for athletes with intellectual impairments: Conceptual approach and efficacy of an ICF derived measure
The purpose of para sport classification systems is to minimise the impact of impairment on competition outcome. Currently, athletes with intellectual impairment (II) compete in one class, regardless of the extent of activity limitation resulting from their impairment. Consequently, athletes with II that cause relatively minor difficulty in sport have a competitive advantage over athletes who have intellectual impairments that cause more significant advantage. This research investigated the efficacy of a measure of health-related functional impairment, derived from the World Health Organisation International Classification of Functioning, Disability, and Health (ICF), as a tool to classify athletes with intellectual impairments (II) into groups with impairments that cause similar activity limitation. The first study used a Delphi technique to identify the most relevant codes within the ICF from which a measure of impairment presence and severity was derived. The second study investigated whether the measure could discriminate between groups of II athletes organised into three competition groups, and whether these groups could be predicted by ICF score. The ICF based questionnaire shows promise as a conceptual approach and as a tool in this context, but this is a preliminary step before establishing a sport-specific approach to classification
Prospects for at CERN in NA62
The NA62 experiment will begin taking data in 2015. Its primary purpose is a
10% measurement of the branching ratio of the ultrarare kaon decay , using the decay in flight of kaons in an unseparated
beam with momentum 75 GeV/c.The detector and analysis technique are described
here.Comment: 8 pages for proceedings of 50 Years of CP
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