Takayasu's arteritis with pyoderma gangrenosum and necrotizing vasculitis

Author Posting. Copyright (c) The Authors 2010 This is the author's version of the work. It is posted here for personal use, not for redistribution. The definitive version was published in CLINICAL AND EXPERIMENTAL DERMATOLOGY, volume:35, issue:3, pages:329-330. https://doi.org/10.1111/j.1365-2230.2009.03534.xArticleCLINICAL AND EXPERIMENTAL DERMATOLOGY. 35(3):329-330 (2010)journal articl

Development of Atmospheric Monitoring System at Akeno Observatory for the Telescope Array Project

We have developed an atmospheric monitoring system for the Telescope Array experiment at Akeno Observatory. It consists of a Nd:YAG laser with an alt-azimuth shooting system and a small light receiver. This system is installed inside an air conditioned weather-proof dome. All parts, including the dome, laser, shooter, receiver, and optical devices are fully controlled by a personal computer utilizing the Linux operating system. It is now operated as a back-scattering LIDAR System. For the Telescope Array experiment, to estimate energy reliably and to obtain the correct shower development profile, the light transmittance in the atmosphere needs to be calibrated with high accuracy. Based on observational results using this monitoring system, we consider this LIDAR to be a very powerful technique for Telescope Array experiments. The details of this system and its atmospheric monitoring technique will be discussed.Comment: 24 pages, 13 figures(plus 3 gif files), Published in NIM-A Vol.488, August 200

脳血栓症治療薬クリンプロストを含有するリピットマイクロスフェアー製剤からの主薬放出特性とその血液脳関門透過機構

取得学位：博士(薬学)，学位授与番号：博乙第127号，学位授与年月日：平成8年9月30日,学位授与年：199

Functional near infrared spectroscopy (fNIRS) to assess cognitive function in infants in rural Africa

Cortical mapping of cognitive function during infancy is poorly understood in low-income countries due to the lack of transportable neuroimaging methods. We have successfully piloted functional near infrared spectroscopy (fNIRS) as a neuroimaging tool in rural Gambia. Four-to-eight month old infants watched videos of Gambian adults perform social movements, while haemodynamic responses were recorded using fNIRS. We found distinct regions of the posterior superior temporal and inferior frontal cortex that evidenced either visual-social activation or vocally selective activation (vocal > non-vocal). The patterns of selective cortical activation in Gambian infants replicated those observed within similar aged infants in the UK. These are the first reported data on the measurement of localized functional brain activity in young infants in Africa and demonstrate the potential that fNIRS offers for field-based neuroimaging research of cognitive function in resource-poor rural communities

Functional near infrared spectroscopy (fNIRS) to assess cognitive function in infants in rural Africa

Cortical mapping of cognitive function during infancy is poorly understood in low-income countries due to the lack of transportable neuroimaging methods. We have successfully piloted functional near infrared spectroscopy (fNIRS) as a neuroimaging tool in rural Gambia. Four-to-eight month old infants watched videos of Gambian adults perform social movements, while haemodynamic responses were recorded using fNIRS. We found distinct regions of the posterior superior temporal and inferior frontal cortex that evidenced either visual-social activation or vocally selective activation (vocal > non-vocal). The patterns of selective cortical activation in Gambian infants replicated those observed within similar aged infants in the UK. These are the first reported data on the measurement of localized functional brain activity in young infants in Africa and demonstrate the potential that fNIRS offers for field-based neuroimaging research of cognitive function in resource-poor rural communities

Photosystem II Peripheral Accessory Chlorophyll Mutants in Chlamydomonas reinhardtii. Biochemical Characterization and Sensitivity to Photo-Inhibition

In addition to the four chlorophylls (Chls) involved in primary charge separation, the photosystem II (PSII) reaction center polypeptides, D1 and D2, coordinate a pair of symmetry-related, peripheral accessory Chls. These Chls are axially coordinated by the D1-H118 and D2-H117 residues and are in close association with the proximal Chl antennae proteins, CP43 and CP47. To gain insight into the function(s) of each of the peripheral Chls, we generated site-specific mutations of the amino acid residues that coordinate these Chls and characterized their energy and electron transfer properties. Our results demonstrate that D1-H118 and D2-H117 mutants differ with respect to: (a) their relative numbers of functional PSII complexes, (b) their relative ability to stabilize charge-separated states, (c) light-harvesting efficiency, and (d) their sensitivity to photo-inhibition. The D2-H117N and D2-H117Q mutants had reduced levels of functional PSII complexes and oxygen evolution capacity as well as reduced light-harvesting efficiencies relative to wild-type cells. In contrast, the D1-H118Q mutant was capable of near wild-type rates of oxygen evolution at saturating light intensities. The D1-H118Q mutant also was substantially more resistant to photo-inhibition than wild type. This reduced sensitivity to photo-inhibition is presumably associated with a reduced light-harvesting efficiency in this mutant. Finally, it is noted that the PSII peripheral accessory Chls have similarities to a to a pair of Chls also present in the PSI reaction center complex

The Anisotropy of Cosmic Ray Arrival Direction around 10^18eV

Anisotropy in the arrival directions of cosmic rays around 10^{18}eV is studied using data from the Akeno 20 km^2 array and the Akeno Giant Air Shower Array (AGASA), using a total of about 216,000 showers observed over 15 years above 10^{17}eV. In the first harmonic analysis, we have found significant anisotropy of $\sim$ 4 % around 10^{18}eV, corresponding to a chance probability of $\sim 10^{-5}$ after taking the number of independent trials into account. With two dimensional analysis in right ascension and declination, this anisotropy is interpreted as an excess of showers near the directions of the Galactic Center and the Cygnus region. This is a clear evidence for the existence of the galactic cosmic ray up to the energy of 10^{18}eV. Primary particle which contribute this anisotropy may be proton or neutron.Comment: 4pages, three figures, to appear in Procedings of 26th ICRC(Salt Lake City