Coexistence of chronic cutaneous lupus erythematosus and frontal fibrosing alopecia

Lupus erythemathosus is a chronic, relapsing disease with acute, subacute, and chronic lesions. Effluvium telogen occurs in the setting of systemic activity of the disease, and cicatricial alopecia results from discoid lesionsin on the scalp. Other types of alopecia, like alopecia areata, may rarely be found in lupus. Frontal fibrosing alopecia is characterized by frontotemporal hairline recession and eybrow loss. Histophatologically, it cannot be differentiated from lichen planopilaris. It is controversial whether frontal fibrosing alopecia is a subtype of lichen planopilaris.. A pacient with chronic lichenoid lupus erythematosus is described with clinical, histophatological and dermoscopic features of frontal fibrosing alopecia. We have not been able to find in the literature cases of frontal fibrosing alopecia as a clinical manifestation of lupus.Univ Fed Sao Paulo, Unifesp, Connect Tissue Dis Outpatient Clin, Dept Dermatol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Unifesp, Dept Dermatol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Unifesp, Dept Anat Pathol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Unifesp, Connect Tissue Dis Outpatient Clin, Dept Dermatol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Unifesp, Dept Dermatol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Unifesp, Dept Anat Pathol, Sao Paulo, SP, BrazilWeb of Scienc

Histological modification in TRAM flap in rats treated with pentoxifylline

PURPOSE: To investigate the blood vessels' concentration in TRAM flap's rat model, in the presence of pentoxifylline.METHODS:32 male, Wistar-EPM rats were divided into two groups. Control group (C): 0.5 ml of saline, intraperitoneally, once a day, for seven days before flap elevation; PTX group (P): pentoxifylline (20mg/kg/day), intraperitoneally, for seven days before flap elevation. After that, they were submitted to a caudal unipedicle TRAM flap. On the fifth postoperative day, percentages of flap necrosis were determined via the paper template method and Tram flap's zone IV skin biopsies were taken for histological analysis.RESULTS:the mean percentage of flap necrosis in group C was 58.7 % and in group P, 31.1 (Wilcoxon test; p = 0.003). Mean capillary vessels number in zone IV's skin in C group was 33.4 and in P group was 71.9 (p=0.008).CONCLUSIONS: Pentoxifylline was effective reducing the necrosis in the caudal unipedicle TRAM flap in the rat as well as increasing the number of capillaries in an ischemic zone (zone IV).UNIFESP Surgery DepartmentUNIFESP Pathology DepartmentUNIFESPUNIFESP, Surgery DepartmentUNIFESP, Pathology DepartmentUNIFESPSciEL

Granuloma anular perfurante simulando tubercúlide pápulo-necrótica

A case is reported of a patient presenting lymph node tuberculosis and cutaneous lesions resembling papulonecrotic tuberculid, but histologically compatible with perforating granuloma annulare and which responded satisfactorily to antituberculous therapy. This is probably one of the first reports of the association of perforating granuloma annulare and tuberculosis, and it is important therefore to highlight the relevance of this disorder in the differential diagnosis of papulonecrotic tuberculid and to raise the hypothesis that this entity should also be considered to be a variant of tuberculid.Os autores relatam o caso de uma paciente com tuberculose ganglionar e lesões cutâneas clinicamente sugestivas de tubercúlide pápulo-necrótica, porém com histopatologia compatível com granuloma anular perfurante, e que apresentaram melhora após tratamento para a tuberculose. Trata-se, possivelmente, de um dos primeiros relatos da associação de granuloma anular perfurante com tuberculose, salientando a importância desta entidade no diagnóstico diferencial da tubercúlide pápulo-necrótica e levantando a possibilidade da mesma ser considerada, também, uma variante de tubercúlide.Universidade Federal de São Paulo (UNIFESP) Department of DermatologyUniversidade Federal de São Paulo (UNIFESP) Department of Dermatology and PathologyUniversidade Federal de São Paulo (UNIFESP) Department of PathologyUNIFESP, Department of DermatologyUNIFESP, Department of Dermatology and PathologyUNIFESP, Department of PathologySciEL

Caso para diagnóstico

Infantile digital fibromatosis or Reye's tumor is a benign fibroproliferative tumor, the etiopathogenesis of which has yet to be fully clarified. It typically presents at birth or in the first year of life and is characterized by a firm, flesh colored or erythematous nodule or nodules located on the digits. These lesions tend to regress spontaneously