Role of IL-33 in inflammation and disease

Interleukin (IL)-33 is a new member of the IL-1 superfamily of cytokines that is expressed by mainly stromal cells, such as epithelial and endothelial cells, and its expression is upregulated following pro-inflammatory stimulation. IL-33 can function both as a traditional cytokine and as a nuclear factor regulating gene transcription. It is thought to function as an 'alarmin' released following cell necrosis to alerting the immune system to tissue damage or stress. It mediates its biological effects via interaction with the receptors ST2 (IL-1RL1) and IL-1 receptor accessory protein (IL-1RAcP), both of which are widely expressed, particularly by innate immune cells and T helper 2 (Th2) cells. IL-33 strongly induces Th2 cytokine production from these cells and can promote the pathogenesis of Th2-related disease such as asthma, atopic dermatitis and anaphylaxis. However, IL-33 has shown various protective effects in cardiovascular diseases such as atherosclerosis, obesity, type 2 diabetes and cardiac remodeling. Thus, the effects of IL-33 are either pro-or anti-inflammatory depending on the disease and the model. In this review the role of IL-33 in the inflammation of several disease pathologies will be discussed, with particular emphasis on recent advances

Compact Binaries as Sources of Gravitational Radiation

With current terrestrial gravitational wave detectors working at initial design sensitivities, and upgrades and space missions planned, it is likely that in the next five to ten years gravitational radiation will be detected directly from a variety of classes of objects. The most confidently expected of these classes is compact binaries, involving neutron stars or black holes. Detection of their coalescence, or their long-term orbits, has the potential to inform us about the evolutionary history of compact binaries and possibly even star formation over the past several billion years. We review what is currently known about compact binaries as sources of gravitational radiation, as well as the current uncertainties and what we expect to learn from future detections of gravitational waves from these systems.Comment: To appear in the proceedings of the meeting "The Multicoloured Landscape of Compact Objects and their Explosive Origins", Cefalu, Italy, June 2006, to be published by AIP, Eds. L. Burderi et a