Oral lichen planus and diabetes mellitus. A clinico-phatological study

A study was made of 72 patients with oral lichen planus associated (n = 28) or not with diabetes mellitus (n = 44). No significant differences were observed between both groups in terms of the location of the lichen planus lesions on the buccal mucosa, palate, gums or floor of the mouth. On the other hand, the diabetics exhibited a greater frequency of oral lichen planus on the tongue. Atrophic-erosive lesions were more common in patients with lichen planus associated with diabetes. Finally, no differences were observed between the two groups in terms of absolute inflammatory infiltrate in the connective tissue of the oral lichen planus lesions.Nous avons effectué une étude sur deux groupes de patients atteints de lichen plan buccal, le premier associé au diabètes sucré (N = 28) et le second (N = 44) sans cette association. Nous n’observons pas de différences significatives entre eux, en ce qui concerne la localisation du lichen plan dans la muqueuse buccale, le palais, les gencives ou le plancher bouche. Nous trouvons cependant une plus grande fréquence de la localisation au niveau de la langue dans le lichen plan avec diabètes. Mais en même temps, nous détectons une fréquence plus importante de lésions atrophiques-érosives dans le premier groupe que dans le second.En dernier lieu, il n’existe pas de différences entre les deux, en ce qui concerne la quantité, en valeur absolue, de l’infiltration inflammatoire dans les tissus conjonctifs des lésions buccales du lichen plan

Oral lichen planus. An evolutive clinical and histological study of 45 patients followed up on for five years

A study is made of 45 patients clinically and histologically diagnosed of oral lichen planus, and followed up on for 5 years. The course of the disease was monitored after three months and one, two and five years. The patients were classified in terms of lesion evolution (healed, improved, stationary or worse). Two evolutive groups were established for statistical purposes: (a) favorable (healed or improved lesions) and unfavorable cases (stationary or worsened oral lesions); and (b) healed and non-healed cases. Statistical correlations were established between these evolutive groups and different clinical and histological parameters, in an attempt to identify parameters of predictive value in the course of the disease. No statistically significant results were obtained, with the exception of inflammatory infiltrate. Thus, the depth of this infiltrate was found to be greater in patients with an unfavorable evolution (p = 0.02) than in those with a favorable course. Likewise, the inflammatory infiltrate was greater in non-healed than in healed cases.Dans ce travail, nous présentons une série de 45 patients, suivis pendant 5 ans, diagnostiqués cliniquement et histologiquement de lichen plan oral. Des contrôles évolutifs réalisés au bout de 3 mois, un an, deux ans et au bout de cinq ans ont classé les patients en fonction de l’évolution qu’ils présentaient en cas qui avaient guéri de leurs lésions, qui s’étaient améliorés, qui continuaient pareil et finalement ceux qui avaient empiré. Vis-à-vis des statistiques 2 groupes évolutifs se sont faits: 1) cas favorables (les guéris et ceux qui s’étaient améliorés), cas défavorables (ceux qui ne présentaient aucun changement ou ceux qui avaient empiré de leurs lésions intraorales) et 2) cas guéris, cas non-guéris. Diverses corrélations statistiques se sont établies entre ces groupes évolutifs et une série de variables cliniques et histologiques pour trouver un paramètre ayant une valeur de prédiction dans l’évolution de la maladie. Nous n’avons trouvé aucune donnée significativement statistique si l’on excepte une infiltration inflammatoire. Ainsi, nous démontrons une plus grande profondité moyenne de celle-ci dans les cas qui présentent une évolution défavorable (p = 0.02) que dans les cas favorables. De la même façon, nous trouvons une plus grande infiltration dans les cas non-guéris que dans les guéris

Influence Of Citrate/nitrate Ratio On The Preparation Of Li 0.5la0.5tio3 Nanopowder By Combustion Method

Preparation of nano-crystalline Li0.5La0.5TiO 3 perovskite material using citrate-nitrate redox reaction by the combustion technique is reported. The role of the ammonium nitrate concentration used to co-precipitate the Li0.5La0.5Ti-citrate precursor is revealed by ATD/TG, XRD, SEM-EDX and HRTEM techniques. Thermo-gravimetric analysis data show how the intensity of the exothermic peak associated with the citrate-nitrate redox reaction decreases until disappearance as the citrate/nitrate molar ratio increases. The XRD study indicates that a single-phase cubic Li0.5La0.5TiO3 phase is formed at 350 C when the citrate/nitrate ratio varies between 0.13 and 0.17. The formed Li0.5La0.5TiO3 powders show an average particle size of 15-20 nm. Electrochemical impedance spectroscopy technique reveals a relative high ionic conductivity inside the grain for the nanometric Li0.5La0.5TiO3 material, with values of around 10-4 S/cm at room temperature. © 2013 Elsevier Ltd and Techna Group S.r.l. All rights reserved.401 PART A249256Armand, M., Tarascon, J.M., Building better batteries (2008) Nature, 451Scrosati, B., Garche, J., Lithium batteries: Status, prospects and future (2010) Journal of Power Sources, 195, pp. 2419-2430Bruce, P.G., Scrosati, B., Tarascon, J.M., Nanomaterials for rechargeable lithium batteries (2008) Angewandte Chemie International Edition, 47, pp. 2930-2946Meethong, N., Huang, H.-Y.S., Carter, W.C., Chiang, Y.-M., Size-dependent lithium miscibility gap in nanoscale Li 1-xFePO4 (2007) Electrochemical and Solid-State Letters, 10, pp. 134-A138Stramare, S., Thangadurai, V., Weppner, W., Lithium lanthanum titanates: A review (2003) Chemistry of Materials, 15, pp. 3974-3990Fergus, J.W., Ceramic and polymeric solid electrolytes for lithium-ion batteries (2010) Journal of Power Sources, 195, pp. 4554-4569Kitaoka, K., Kozuka, H., Hashimoto, T., Yoko, T., Preparation of La0.5Li0.5TiO3 perovskite thin films by the sol-gel method (1997) Journal of Materials Science, 32, pp. 2063-2070Vijayakumar, M., Pham, Q.N., Bohnke, C., Lithium lanthanum titanate ceramic as sensitive material for pH sensor: Influence of synthesis methods and powder grains size (2005) Journal of the European Ceramic Society, 25, pp. 2973-2976Pechini, M.P., (1967) Method of Preparing Lead and Alkaline Titanates and Niobiates and Coating Method Using the Same to Form A Capacitor, USA, p. 697Vijayakumar, M., Inaguma, Y., Mashiko, W., Crosnier-López, M.-P., Bhonke, C., Synthesis of fine powders of Li3xLa2/3-xTiO 3 perovskite by a polymerizable precursor method (2004) Chemistry of Materials, 16, pp. 2719-2724Pham, Q.N., Bohnke, C., Lopez, M.P.C., Bohnke, O., Synthesis and characterization of nanostructured fast ionic conductor Li0.30La0.56TiO3 (2006) Chemistry of Materials, 18, pp. 4385-4392Behera, S.K., Barpanda, P., Pratihar, S.K., Bhattacharyya, S., Synthesis of magnesium-aluminium spinel from autoignition of citrate-nitrate gel (2004) Materials Letters, 58, pp. 1451-1455Werde, G.V.K.V., Mondelaers, D., Rul, H.D., Bael, M.K.V., Mullens, J., Poucke, L.C.V., The aqueous solution-gel synthesis of perovskite Pb(Zr 1-xTix)O3 (PZT) (2007) Journal of Materials Science, 42, pp. 624-632Purohit, R.D., Saha, S., Tyagi, A.K., Nanocrystalline thoria powders via glycine-nitrate combustion (2001) Journal of Nuclear Materials, 288, pp. 7-10Chakrabarti, N., Maiti, H.S., Chemical synthesis of PZT powder by auto-combustion of citrate-nitrate gel (1997) Materials Letters, 30, pp. 169-173Marinsek, M., Zupan, K., Maeek, J., Ni-YSZ cermet anodes prepared by citrate/nitrate combustion synthesis (2002) Journal of Power Sources, 106, pp. 178-188Jain, S.R., Adiga, K.C., Verneker, V.R.P., A new approach to thermochemical calculations of condensed fuel-oxidizer mixtures (1981) Combustion and Flame, 40, pp. 71-79Zupan, K., Kolar, D., Marinsek, M., Influence of citrate-nitrate reaction mixture packing on ceramic powder properties (2000) Journal of Power Sources, 86, pp. 417-422Folly, P., Mädera, P., Propellant chemistry (2004) CHIMIA International Journal for Chemistry, 58, pp. 374-382Singh, K.A., Pathak, L.C., Roy, S.K., Effect of citric acid on the synthesis of nano-crystalline yttria stabilized zirconia powders by nitrate-citrate process (2007) Ceramics International, 33, pp. 1463-1468Otero, T., Mosqueda, Y., Miilian, C.R., Perez-Cappe, E., Li3xLa2/3-xTiO3 nanoparticles obtained from a low temperature synthesis route (2011) Journal of Nano Research, 14, pp. 107-113Théoret, A., Sandorfy, C., Infrared spectra and crystalline phase transitions of ammonium nitrate (1964) Canadian Journal of Chemistry, 42, pp. 57-62Zhecheva, R.S.E., Gorova, M., Alcántara, R., Morales, J., Tirado, J.L., Lithium-cobalt citrate precursors in the preparation of intercalation electrode materials (1996) Chemistry of Materials, 8, pp. 1429-1440Todorovsky, D.S., Getsova, M.M., Wawer, I., Stefanov, P., Enchev, V., On the chemical nature of lanthanum-titanium citric complexes, precursors of La2Ti2O7 (2004) Materials Letters, 58, pp. 3559-3563Dakanali, M., Kefalas, E.T., Raptopoulou, C.P., Terzis, A., Voyiatzis, G., Kyrikou, I., Mavromoustakos, T., Salifoglou, A., A new dinuclear Ti(IV)-peroxo-citrate complex from aqueous solutions. 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Trend and Network Analysis of Common Eligibility Features for Cancer Trials in ClinicalTrials.gov

ClinicalTrials.gov has been archiving clinical trials since 1999, with > 165,000 trials at present. It is a valuable but relatively untapped resource for understanding trial design patterns and acquiring reusable trial design knowledge. We extracted common eligibility features using an unsupervised tag-mining method and mined their temporal usage patterns in clinical trials on various cancers. We then employed trend and network analysis to investigate two questions: (1) what eligibility features are frequently used to select patients for clinical trials within one cancer or across multiple cancers; and (2) what are the trends in eligibility feature adoption or discontinuation across cancer research domains? Our results showed that each cancer domain reuses a small set of eligibility features frequently for selecting cancer trial patients and some features are shared across different cancers, with value range adjustments for numerical measures. We discuss the implications for facilitating community-based clinical research knowledge sharing and reuse