Improving tuberculosis surveillance in Europe is key to controlling the disease.

As underlined by the joint ECDC and World Health Organization Regional Office for Europe TB report, launched on 18 March the importance of good surveillance to stem this trend cannot be underestimated. Where do we go with surveillance in Europe? Can we do more? How many MDR and XDR TB cases occur because of sub-optimal patient management? This issue of Eurosurveillance casts light on these important questions with four interesting articles. The results of the studies reported in this issue of Eurosurveillance allow us to point out some key topics: \u2022The completeness of reporting information (including treatment outcomes), the proportion of culture-confirmed TB cases reported as well as the proportion of strains on which DST for both first- and second-line drugs is performed and reported are still sub-optimal overall in Europe. The relevance of these pitfalls goes beyond the \u201csimple\u201d surveillance limitation, having the potential to affect other important TB control pillars, e.g. infection control and case-management. \u2022MDR and XDR TB still persist in Europe. The high proportion of MDR TB identified among new TB cases reported by certain countries indicates that sub-optimal infection control practices are likely to occur, while the high percentage of MDR TB notified among retreatment cases is probably the result of sub-optimal case management in the past decade

Adverse Events among HIV/MDR-TB Co-Infected Patients Receiving Antiretroviral and Second Line Anti-TB Treatment in Mumbai, India.

Significant adverse events (AE) have been reported in patients receiving medications for multidrug- and extensively-drug-resistant tuberculosis (MDR-TB & XDR-TB). However, there is little prospective data on AE in MDR- or XDR-TB/HIV co-infected patients on antituberculosis and antiretroviral therapy (ART) in programmatic settings

Quantum Phase Transition in the Normal State of High-Tc Cuprates at Optimum Doping

By using a 60 T magnetic field to suppress superconductivity in La2-pSrpCuO4, (LSCO) we reveal an anomalous peak in the Hall number, located at optimum doping and developing at temperatures below the zero-field superconducting transition temperature, Tc. The anomaly bears a striking resemblance to observations in Bi2Sr2-xLaxCuO6+delta (BSLCO) [F. F. Balakirev et al., Nature (London) 424, 912 (2003)], suggesting a normal state phenomenology common to the cuprates that underlies the high-temperature superconducting phase. The peak is ascribed to the transformation of the "Fermi arcs" into a conventional FS, the signature of a Fermi surface reconstruction associated with a quantum phase transition (QPT) near optimum doping and co-incident with the collapse of the pseudogap state.Comment: 16 pages, 4 figure

The TeV-emitting radio galaxy 3C 264. VLBI kinematics and SED modeling

Context. In March 2018, the detection by VERITAS of very-high-energy emission (VHE > 100 GeV) from 3C 264 was reported. This is the sixth, and second most distant, radio galaxy ever detected in the TeV regime. Aims: In this article we present a radio and X-ray analysis of the jet in 3C 264. We determine the main physical parameters of the parsec-scale flow and explore the implications of the inferred kinematic structure for radiative models of this γ-ray emitting jet. Methods: The radio data set is comprised of VLBI observations at 15 GHz from the MOJAVE program, and covers a time period of about two years. Through a segmented wavelet decomposition method (WISE code), we estimated the apparent displacement of individual plasma features; we then performed a pixel-based analysis of the stacked image to determine the jet shape. The X-ray data set includes all available observations from the Chandra, XMM, and Swift satellites, and is used, together with archival data in the other bands, to build the spectral energy distribution (SED). Results: Proper motion is mostly detected along the edges of the flow, which appears strongly limb brightened. The apparent speeds increase as a function of distance from the core up to a maximum of ̃11.5 c. This constrains the jet viewing angle to assume relatively small values (θ ≲ 10°). In the acceleration region, extending up to a de-projected distance of ̃4.8 × 104 Schwarzschild radii (̃11 pc), the jet is collimating (r ∝ z0.40 ± 0.04), as predicted for a magnetically-driven plasma flow. By assuming that the core region is indeed magnetically dominated (UB/Ue > 1), the SED and the jet power can be well reproduced in the framework of leptonic models, provided that the high-energy component is associated to a second emitting region. The possibility that this region is located at the end of the acceleration zone, either in the jet layer or in the spine, is explored in the modeling

The TeV-emitting radio galaxy 3C 264. VLBI kinematics and SED modeling

Context. In March 2018, the detection by VERITAS of very-high-energy emission (VHE > 100 GeV) from 3C 264 was reported. This is the sixth, and second most distant, radio galaxy ever detected in the TeV regime. Aims: In this article we present a radio and X-ray analysis of the jet in 3C 264. We determine the main physical parameters of the parsec-scale flow and explore the implications of the inferred kinematic structure for radiative models of this γ-ray emitting jet. Methods: The radio data set is comprised of VLBI observations at 15 GHz from the MOJAVE program, and covers a time period of about two years. Through a segmented wavelet decomposition method (WISE code), we estimated the apparent displacement of individual plasma features; we then performed a pixel-based analysis of the stacked image to determine the jet shape. The X-ray data set includes all available observations from the Chandra, XMM, and Swift satellites, and is used, together with archival data in the other bands, to build the spectral energy distribution (SED). Results: Proper motion is mostly detected along the edges of the flow, which appears strongly limb brightened. The apparent speeds increase as a function of distance from the core up to a maximum of ̃11.5 c. This constrains the jet viewing angle to assume relatively small values (θ ≲ 10°). In the acceleration region, extending up to a de-projected distance of ̃4.8 × 104 Schwarzschild radii (̃11 pc), the jet is collimating (r ∝ z0.40 ± 0.04), as predicted for a magnetically-driven plasma flow. By assuming that the core region is indeed magnetically dominated (UB/Ue > 1), the SED and the jet power can be well reproduced in the framework of leptonic models, provided that the high-energy component is associated to a second emitting region. The possibility that this region is located at the end of the acceleration zone, either in the jet layer or in the spine, is explored in the modeling

The inner flow geometry in MAXI J1820+070 during hard and hard-intermediate states

[Abridged] Context: We present a systematic X-ray spectral-timing study of the recently discovered, exceptionally bright black hole X-ray binary system MAXI J1820+070. Our analysis focuses on the first part of the 2018 outburst, covering the rise throughout the hard state, the bright hard and hard-intermediate states, and the transition to the soft-intermediate state. Aims: We address the issue of constraining the geometry of the innermost accretion flow and its evolution throughout an outburst. Methods: We employed two independent X-ray spectral-timing methods applied to the NICER data of MAXI J1820+070. We first identified and tracked the evolution of a characteristic frequency of soft X-ray reverberation lags. Then, we studied the spectral evolution of the quasi-thermal component responsible for the observed thermal reverberation lags. Results: The frequency of thermal reverberation lags steadily increases throughout most of the outburst, implying that the relative distance between the X-ray source and the disc decreases as the source softens. However, near transition this evolution breaks, showing a sudden increase (decrease) of lag amplitude (frequency). The evolution of the quasi-thermal component in high-frequency covariance spectra is consistent with a steady decrease of the inner radius of the disc as the source softens. Conclusions: The behaviour of thermal reverberation lags near transition might be related to relativistic plasma ejections detected at radio wavelengths later in the outburst, possibly representing the precursor to such events. Throughout most of the hard and hard-intermediate states the disc is consistent with being truncated (with an inner radius $R_{\rm in}>\sim 10 R_{\rm g}$), reaching close to the innermost stable circular orbit only near transition.Comment: Submitted for publication in Astronomy & Astrophysic