19 research outputs found

    A MODEL EVALUATION PROTOCOL FOR URBAN SCALE FLOW AND DISPERSION MODELS

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    This paper reports on a comprehensive model evaluation protocol for urban scale flow and dispersion models that has been developed within the framework of the COST action 732 on Quality Assurance and Improvement of Micro-Scale Meteorological Models. It briefly discusses the different components forming model evaluation with particular emphasis on model validation and on the implementation of the protocol for a specific test case: the MUST (Mock Urban Setting Test) experiment. The protocol was first developed with building-resolving models in mind, but more traditional integral models have also been included. Currently the Action is finalising the MUST exercise results and will suggest the best approach for further model evaluation and for the standardization of CFD modelling practise for micro-scale meteorological applications

    Plasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertility.

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    Calcium and Ca(2+)-dependent signals play a crucial role in sperm motility and mammalian fertilization, but the molecules and mechanisms underlying these Ca(2+)-dependent pathways are incompletely understood. Here we show that homozygous male mice with a targeted gene deletion of isoform 4 of the plasma membrane calcium/calmodulin-dependent calcium ATPase (PMCA), which is highly enriched in the sperm tail, are infertile due to severely impaired sperm motility. Furthermore, the PMCA inhibitor 5-(and-6)-carboxyeosin diacetate succinimidyl ester reduced sperm motility in wild-type animals, thus mimicking the effects of PMCA4 deficiency on sperm motility and supporting the hypothesis of a pivotal role of the PMCA4 on the regulation of sperm function and intracellular Ca(2+) levels
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