Interaction with air pollution exposure for genetic loci associated with lung function

Air pollution has been found to be associated with reduced lung function; also 279 genetic signals of association with lung function have been identified that implicate multiple genes and pathways. In this study, we examined if any of these signals interact with air pollution measures NO2, PM2.5 and PM10.In 259,389 unrelated European individuals from UK Biobank, we tested for a gene-environment interaction effect on lung function with NO2, PM2.5 and PM10 for each of the 279 signals. Lung function measures (FEV1, FEV1/FVC and FVC) were adjusted for sex, age, age2, height, and smoking, income and educational status, with adjustment for 15 principal components for fine-scale population structure. A significance threshold of PWe found statistically significant evidence for an interaction with PM2.5 on FEV1/FVC for rs10841302 on chromosome 12 (minor allele frequency=45.2%, interaction P=1.55x10-5). The SNP was also nominally significant for an interaction with PM10 and NO2 (P=5.2x10-4 and 2.3x10-3, respectively). This SNP did not show an interaction with tobacco smoke in a previous analysis. A further 16 SNPs had a nominally significant (PThe gene underlying the association of rs10841302 with lung function has not been determined but the SNP lies close to the AEBP2 gene which encodes AE Binding Protein 2, a transcriptional repressor which may have a role in histone methylation. Identification and characterisation of genes whose effect is influenced by air pollution exposure will enable us to understand how the environment influences respiratory health.</p

Images Of Research 2016

Images Of Research 2016 Winners: Damian Roland – ‘Spotting the Sick Child – Development of the ‘POPS’ tool‘ - Winner of the Best Image from the College of Medicine, Biological Sciences and Psychology Sarah Hainsworth – ‘Fly Pupae’ - Winner of the Best Image from the College of Science and Engineering Stevie-Jade Hardy – ‘A Human Right’ - Winner of the Best Image from the College of Social Sciences, Arts and Humanities Chris Nixon – ‘Star Eaters’ - Winner of the Peoples Choice Award Mark Williams – ‘Creature From the Black Lagoon’ - Winner of the Best Postgraduate Researcher Image Josephina Sampson – ‘Clustered centrosomes in cancer’ - Second Place for the Best Postgraduate Researcher Image Images Of Research 2016 successful submissions: Aarti Patel – ‘Untitled’ Alex Sutton – ‘Visualisations to assist the analysis of “Which treatment is best?”: a collaboration between medical statisticians and computer scientists from academia and industry’ Andrew Fry – ‘Understanding the mechanics of cancer cell division’ Andrew Hopper – ‘Leicester historians with the wheelchair of Sir Thomas Fairfax at the National Civil War Centre’ Benjamin Hall – ‘The Martian Space Plasma Environment’ Chee Kay Cheung – ‘Shining a light into the kidney’ Christine Pulla – ‘The web of life’ Clare Gunby – ‘The Pocket‘ Dan Stewart – ‘Geophysical Survey of Roman Knossos’ David Siveter – ‘Spectacular 430 MILLION-YEAR-OLD ‘VIRTUAL FOSSILS’ help interpret the evolution of life’ Dawn Watkins – ‘Law in Children’s Lives ‘ Duncan Murdock – ‘Fossils Are Rotten’ Elizabeth Jones – ‘Small Town Urbanity in Nineteenth-Century Wales.’ Emma Jones – ‘An invitation to imagine a world where complete accounts of research are always published’ Emma Raven – ‘Iron Heart of the Crystal – Neutron crystal structure of ascorbate peroxidase compound II’ Geoff Belknap – ‘Citizen Science, and the Uncovering of History of Female Scientists’ Giannis Koukkidis – ‘Salads and Salmonellas’ Giovanna Puppin – ‘Advertising Cultures‘ Janet Nale – ‘Clostridium difficile bacteriophages are effective anti-biofilm agents’ John Goodwin – ‘Pearl Jephcott (1900-1980): The ‘Czechoslovakia’ Notebook’ Jun Li – ‘Untitled’ Kristina Wright – ‘Kenyan artist Michael Soi painting at an exhibition of his work in Seoul, South Korea.’ Laura Gray – ‘Are activity trackers telling us the truth about our physical activity level?’ Loveday Hodgeson – ‘Feminist International Judgments Project: Women’s Voices in International Law’ Luciano Ost – ‘Embedding smart and runtime techniques to improve multi-core systems’ reliability’ Maria Theresia Walach – ‘The Auroral Heart’ Mesut Erzurumluoglu – ‘Breathtaking genes’ Michael Barer – ‘SURVIVAL OF THE FATTEST – a TB bacterium (approximately 0.003 mm in length)’ Nicholas Vass – ‘Visual Community Organising’ Paul Dickinson – ‘A Brightspot on a glass darkly’ Emmanuel Georgoulis, Dr Andrew Norozov and Andrea Cangiani – ‘Chaotic Ice Cream Cones’ Ravi Purohit, Dr Zhanhan Tu, Helen Kuht – ‘Infants’ eye scan’ Rob Hirst – ‘Transmission Electron Microscope image of the unusual case of swollen human respiratory cilia’ Rona Aldo – ‘Supersonic flow modelling thrusts forward airframe-engine design integration of large twin aircraft’ Rozita Adib – ‘The microtubule cytoskeleton‘ Ruslan Davidchack – ‘Tadpole’ Sarah Johnson – ‘Persistence of Flood Waters - Vale of York - Autumn 2015’ Sarah Thornton – ‘Senyum‘ Tu Zhanhan – ‘Hope’ Wendy Fitzgibbon – ‘Supervisible’ Yewande Okuleye – ‘Sense about Cannabis’ </p