Antioxidant Defense System in Behcet’S Disease

DergiPark: 379004tmsjBehcet’s disease (BD), first described by the Turkish dermatologist Hulusi Behcet in 1937, is characterized by triad of symptoms that include oral aphthous lesions, genital ulcerations and iritis with hypopyon. The etiopathogenesis is not yet fully explained, although reactive oxygen species produced (ROS) by the hyperfunction of neutrophils which are significant for the immune response are thought to play a role. Antioxidant defense system protects the body against the harmful effects of reactive oxygen species. Normally, there is a balance between reactive oxygen species and antioxidant defense system but as levels of reactive oxygen species are above the body’s neutralization and elimination ability disrupts the balance. With the imbalance, increased levels of reactive oxygen species disrupt biomolecules such as lipids, proteins, nucleic acids and cause cell, tissue and organ damage. Studies with parameters associated with antioxidant defense system are included in our study. When viewed as whole, most of the studies support that imbalance between oxidants/antioxidants plays a role in etiopathogenesis of Behcet’s disease but it should not be forgotten that there are studies show otherwise. Reactive oxygen species affect patients with active disease more than patients with inactive disease. In conclusion, studies classified in detail with larger group of patients on Behcet’s disease are needed. If patients’ clinical findings and levels of oxidants and antioxidants are interpreted together in the studies, they can be used to monitor the disease and success of the therap

Assessment of Inpatients in Trakya University Hospital in Terms of Informed Consent Indicated by Ministry of Health’S Patient Rights Regulations

DergiPark: 379044tmsjAims: The informed consent constitutes the legal validity of any medical intervention and treatment, and it provides the patient with information about the procedure. In this study, we aimed to assess the extent informed consent is being applied in Trakya University Hospital in accordance to Ministry of Health’s regulations.Methods: A data collecting form has been prepared with respect to Ministry of Health’s relevant regulations and it was applied to 78 inpatients. The form consists of 18 two-point statements and 4 questions towards the patient’s demographic profile. As for descriptive statistics, numbers and percentages have been used for the statements, thus arithmetic mean ± standard deviation (minimum-maximum) has been used for the questions, respectively.Results: Out of all included patients, 47 (60.3 %) participants did not have any knowledge about the Informed Consent Form, 24 (30.8%) did not sign the Form, 48 (61.5%) participants did not read the Form and 49 (62.8%) did not understand the Form.Conclusion: From the results of this study, it can be inferred that the extent patients are being informed is still not on intended levels and is not satisfactory. Informed Consent is still a topic to emphasize, improve and put into practice more effectivel

Preoperative Lipid Profile of Patients Operated For Coronary Bypass Surgery

DergiPark: 379072tmsjAims: Dyslipidemia is a major risk factor for atherosclerosis and coronary heart disease. Evidence showed that an atherogenic lipid pattern is characterized by high levels of small, dense low-density lipoprotein, low levels of high-density lipoprotein cholesterol, elevated triglyceride and total cholesterol levels; similar with the lipid profiles of diabetics.Methods: In this study, 91 patients who underwent coronary artery bypass grafting in Trakya University Hospital Department of Cardiovascular Surgery from April 2017 to September 2017 were analyzed retrospectively. As for statistical analysis, Student’s t-test and Mann Whitney U tests were performed.Results: The lipid profiles of patients were not significantly related to their ages and genders. However, when diabetic patients’ lipid profiles were analyzed, their low-density lipoprotein, and total cholesterol values were found to be significantly lower.Conclusion: It is unexpected to see that patients with diabetes had significantly lower total cholesterol and low-density lipoprotein levels than non-diabetic patients. As for the reason, it is thought that patients with diabetes are more conscious of their health conditio