Effect of mirabegron on overactive bladder symptoms in patients with myasthenia gravis disease

Aim: Overactive bladder (OAB) is a chronic, bothersome disease that decreases the quality of life and can be treated with antimuscarinic or β(3)-adrenergic agonist drugs, such as mirabegron. Myasthenia gravis (MG) is an autoimmune disease, in which neurotransmission is blocked by antibodies. Mirabegron is recommended as the first-line medical treatment for OAB compared with antimuscarinic drugs, which have several severe side effects. In this study, we assessed the efficacy of mirabegron in patients with MG and OAB. Methods: A total of 57 MG patients with OAB were included in this study. The participants received 50 mg mirabegron once daily and were followed up for 4 weeks. Subsequently, patients were evaluated using the International Consultation on Incontinence-Short Form and the "Overactive Bladder Symptom Score" (OABSS) and tasked to complete a 3-day micturition diary. Results: According to the 4-week follow-up results, the decrease in the OABSS scores following mirabegron administration was statistically significant (p<0.001). In addition, the frequency of daily micturition, nocturia, and need for a daily pad decreased dramatically (p=0.001, p=0.002, and p<0.001, respectively). In contrast, the average voiding volume increased significantly (p=0.001). Conclusions: Although they induce several side effects, antimuscarinic drugs are commonly used for OAB treatment. However, only a few autoimmune response-inducing drugs, with minimal side effects, are favored in MG comorbidity treatments. Thus, mirabegron is a promising candidate drug for the treatment of this type of comorbidity

Evaluation of YouTube Videos Regarding Clean Intermittent Catheterization Application

Purpose: The aim of this study was to assess the clean intermittent catheterization (CIC) training and education videos on YouTube

Anxiety Levels and Sexual Functions of Patients Performing Clean Intermittent Catheterization

Clean intermittent catheterization (CIC) is an effective and reliable catheterization method widely used to ensure bladder management. However, pain or discomfort that is commonly seen during catheterization in individuals performing CIC may lead to anxiety and changes in many activities of daily living, particularly in sexual function. The aim of this study was to determine the anxiety levels and sexual functions of patients performing CIC and the relationship between. This descriptive study included a total of 102 patients performing CIC who were followed at a urology outpatient clinic of a state hospital. Data were collected by using Structured Information Form, Visual Analog Scale (VAS), State-Trait Anxiety Inventory (STAI), Female Sexual Function Scale (FSFI) and International Erectile Function Index-5 (IIEF-5). Statistical analyses were performed using descriptive statistical methods, Pearson Product-Moment Correlation Coefficient and Regression Analysis. Mood scores (VAS) of the patients were 6.56 +/- 1.52. The mean IIEF-5 score was 8.47 +/- 4.59 in male patients and the mean FSFI score was 17.62 +/- 6.2 in female patients. Erectile dysfunction was found in 73.47% of male patients and sexual dysfunction was present in 64.15% of female patients. The STAI-1 score was found to have a negative moderate correlation with IIEF-5 and FSFI scores (p <= 0.05). Furthermore, evaluation of the factors related to sexual dysfunction showed that smoking, female sex, anxiety level, duration of CIC, mood and wheelchair use increased the probability of developing sexual dysfunction. Determining the anxiety and sexual function levels of individuals performing CIC, prioritizing the factors that may affect sexual function, and using appropriate therapeutic approaches are thought to be able to increase the individual's adaptation and have a positive effect on their sexual lives

Analysis of the YouTube videos on pelvic floor muscle exercise training in terms of their reliability and quality

Purpose The aim of this study was to evaluate the content, reliability and quality of YouTube videos related to pelvic floor muscle exercise training. Method This study was carried out on the descriptive model in order to evaluate the content, reliability and quality of the videos on YouTube related to pelvic floor muscle exercise training. "Pelvic floor muscle exercise" was searched on YouTube in English in March 2020, and a total of 107 videos were watched. Quality Criteria for Consumer Health Information (DISCERN) survey was used to analyze the videos in terms of their reliabilities, and Global Quality Score (GQS) was used to evaluate their qualities. Results When the contents of 59 videos included in the study were examined, it was determined that 52 of them contained useful information and 7 of them contained misleading information. Comprehensiveness mean scores, DISCERN mean scores and GQS means of the useful videos were found to be statistically higher than that of the moderate and misleading videos (p < 0.05).When videos were analyzed according to the publishing sources, 84.62% (44/52) of the useful videos and 85.71% (6/7) of misleading video were observed to be published by independent health information websites. No statistically significant difference was found between the overall comprehensiveness mean scores, DISCERN mean scores, GQS means and the features of the videos according to their publishing sources. Conclusion In this study, it was observed that the vast majority of YouTube videos on pelvic floor muscle exercise training were useful videos; the vast majority of these videos were published by independent health information websites and contained moderately safe, accurate and quality information

"TANGO" nocturia scanning tool: Turkish validity and reliability study

Background The aim of this study is to evaluate the validity and reliability of the Targeting the Individual's Aetiology of Nocturia to Guide Outcomes (TANGO) screening tool, which is used to determine nocturia etiology. Methods Patients hospitalized in urology, orthopedics, and general surgery clinics between September 2019 and January 2020 were included in the study. Demographic characteristics of the participants such as age, gender, drug use, and nocturia severity were assessed by the researchers. The Turkish version of the TANGO questionnaire consisting of 22 questions was filled in by the patients. The patients were asked to repeat the same test 4 weeks later. Results A total of 124 patients were included in the study. The mean age of the patients participating in the study was 51.20 +/- 18.50 (38-82). The result of the reliability assessment showed that the total score intraclass correlation coefficient was 0.715 (individual item score weighted kappa coefficients, 0.696-0.731) and the Cronbach's alpha coefficient was 0.727. A total of 112 patients filled in the TANGO screening tool again after 4 weeks. The test-retest reliability analysis kappa value was 0.75 (0.68-0.83). In the validity analysis, a moderately positive correlation was observed between the TANGO-Urinary Incontinence Score and the number of nocturia (r = 0.452,P= .003). Conclusion According to the validation study, the TANGO screening tool is valid and reliable to determine the nocturia etiology for the Turkish population

The Effect on Pain and Anxiety of Hot Pad Applied to Patients During Transrectal Prostate Biopsy

Aim: The aim of the study was to evaluate the effect of the application of a heating pad on the sacral region on pain and anxiety during a transrectal prostate biopsy

The effects of bladder training on bladder functions after transurethral resection of prostate

Aim and Objectives The aim of this was to examine the effect of bladder training on bladder functions