Antineutrophil cytoplasmic antibodies in myelodysplasia.

Antibodies to neutrophil cytoplasmic antigens (ANCA) are good serological markers for patients with mainly vasculitic conditions. Two main types of ANCAs have been detected, the first termed cytoplasmic antineutrophil cytoplasmic antibody (cANCA) are mainly associated with patients with Wegener's granulomatosis, the other termed perinuclear antineutrophil cytoplasmic antibody (pANCA) are mainly associated with patients with renal vasculitis, rheumatic and collagen disorders. These antibodies are against various constituents of neutrophil granules. In patients with myelodysplasia, defects in normal granulocyte development are seen. We report a series of twelve patients with myelodysplasia of whom at least four showed a low titre and one a high titre of pANCA. Two of these patients also had demonstrable activity against myeloperoxidase (MPO). None of these patients had any evidence of systemic or cutaneous vasculitis or of any autoimmune disorder. There was no pANCA positivity in an age matched control group

First observations with CONDOR, a 1.5 THz heterodyne receiver

The THz atmospheric windows centered at roughly 1.3 and 1.5~THz, contain numerous spectral lines of astronomical importance, including three high-J CO lines, the N+ line at 205 microns, and the ground transition of para-H2D+. The CO lines are tracers of hot (several 100K), dense gas; N+ is a cooling line of diffuse, ionized gas; the H2D+ line is a non-depleting tracer of cold (~20K), dense gas. As the THz lines benefit the study of diverse phenomena (from high-mass star-forming regions to the WIM to cold prestellar cores), we have built the CO N+ Deuterium Observations Receiver (CONDOR) to further explore the THz windows by ground-based observations. CONDOR was designed to be used at the Atacama Pathfinder EXperiment (APEX) and Stratospheric Observatory For Infrared Astronomy (SOFIA). CONDOR was installed at the APEX telescope and test observations were made to characterize the instrument. The combination of CONDOR on APEX successfully detected THz radiation from astronomical sources. CONDOR operated with typical Trec=1600K and spectral Allan variance times of 30s. CONDOR's first light observations of CO 13-12 emission from the hot core Orion FIR4 (= OMC1 South) revealed a narrow line with T(MB) = 210K and delta(V)=5.4km/s. A search for N+ emission from the ionization front of the Orion Bar resulted in a non-detection. The successful deployment of CONDOR at APEX demonstrates the potential for making observations at THz frequencies from ground-based facilities.Comment: 4 pages + list of objects, 3 figures, to be published in A&A special APEX issu