23 research outputs found
U.S. Foreign Policy and its Historical Development
This morning it is my duty and my privilege to discuss with you some of the major features of the United States Foreign Policy and to point out the historical development of some of these features
Jungle paths and Inca ruins.
Photocopy.Mode of access: Internet.
Fo jia zhe xue tong lun / yuan zhu zhe Wm. M. McGovern ; yi shu zhe Jiang Shaoyuan 佛家哲學通論 / 原著者Wm. M. McGovern ; 譯述者江紹原
On double leaves, oriental style
Tranlation of: A manual of Buddhist philosoph
The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.
Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the major histocompatibility complex (MHC); however, the basis for these associations remains elusive. To define host genetic effects on the outcome of a chronic viral infection, we performed genome-wide association analysis in a multiethnic cohort of HIV-1 controllers and progressors, and we analyzed the effects of individual amino acids within the classical human leukocyte antigen (HLA) proteins. We identified >300 genome-wide significant single-nucleotide polymorphisms (SNPs) within the MHC and none elsewhere. Specific amino acids in the HLA-B peptide binding groove, as well as an independent HLA-C effect, explain the SNP associations and reconcile both protective and risk HLA alleles. These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection