Individual participant FERT results

Individual participant FERT results showing percentage misclassification of other face emotions as sad. Shaded cells represent no data available. This data was used to generate Figure 2

Individual participant EREC data

Individual participant EREC data showing number of negative and positive self-referent words falsely recalled for the HC and MDD groups across the 3 visits. Shaded cells represent no data available. This data was used to generate Figure 4

Individual participant mood scores

Individual participant mood scores. This data was used to generate Table 2

MDD individual participant HAM-D scores

MDD individual participant HAM-D scores taken at test visit 1 (baseline) and test visit 3 (final). This data was used to generate Figure 1

Individual reward task data

Individual reward task data showing % correct & incorrect symbol choices. This data was used to generate Figure 5

Individual participant ECAT results

Individual participant ECAT data of % accuracy for positive and negative self-referent words for the HC and MDD groups across the 3 visits. Shaded cells represent no data available. This data was used to generate Figure 3

Detailed Descriptions of the Behavioral Tasks from Dissociable temporal effects of bupropion on behavioural measures of emotional and reward processing in depression

Antidepressants remediate negative biases in emotional processing early in treatment, prior to mood improvement. However, the effects on reward processing potentially relevant to the treatment of anhedonia are less clear. Here we investigate the early and sustained effects of the dopamine and noradrenaline reuptake inhibitor bupropion on behavioural measures of emotional and reward processing in currently depressed individuals. Forty-six currently depressed patients and 42 healthy controls participated in a repeated measures study, during which open-label bupropion was administered to only the patient group over a six week period without a placebo group. All participants completed the Emotional Test Battery and a probabilistic instrumental learning task at week 0, week 2 and week 6. Currently depressed patients displayed negative biases in emotional processing and blunted response bias for high-probability wins compared to the healthy controls at baseline. Bupropion was found to reduce the negative biases in emotional processing early in treatment, including a significant decrease in the percentage misclassification of other face emotions as sad and the number of negative self-referent words falsely recalled between baseline and week 2. Conversely, bupropion was found to initially further reduce the response bias for high-probability wins between baseline and week 2. This effect reversed with six weeks bupropion treatment and reward processing was normalized compared to the healthy controls. Early in treatment, bupropion acts to reduce negative biases in emotional processing but exacerbates impaired reward processing. The beneficial actions of bupropion on reward processing then occur later in treatment. Such dissociation in the temporal effects of bupropion on emotional and reward processing has implications for the treatment of the different symptom domains of negative affect and anhedonia in depression.This article is part of a discussion meeting issue ‘Of mice and mental health: facilitating dialogue between basic and clinical neuroscientists’