The Development of Egalitarianism, Altruism, Spite and Parochialism in Childhood and Adolescence

We study how the distribution of other-regarding preferences develops with age. Based on a set of allocation choices, we can classify each of 717 subjects, aged 8 to 17 years, as either egalitarian, altruistic, or spiteful. Varying the allocation recipient as either an in-group or an out-group member, we can also study how parochialism develops with age. We find a strong decrease in spitefulness with increasing age. Egalitarianism becomes less frequent, and altruism much more prominent, with age. Women are more frequently classified as egalitarian than men, and less often as altruistic. Parochialism first becomes significant in the teenage years.other-regarding preferences, egalitarianism, altruism, spite, parochialism, experiments with children and adolescents

Industrialising Software Development in Systems Integration

Compared to other disciplines, software engineering as of today is still dependent on craftsmanship of highly-skilled workers. However, with constantly increasing complexity and efforts, existing software engineering approaches appear more and more inefficient. A paradigm shift towards industrial production methods seems inevitable. Recent advances in academia and practice have lead to the availability of industrial key principles in software development as well. Specialization is represented in software product lines, standardization and systematic reuse are available with component-based development, and automation has become accessible through model-driven engineering. While each of the above is well researched in theory, only few cases of successful implementation in the industry are known. This becomes even more evident in specialized areas of software engineering such as systems integration. Today’s IT systems need to quickly adapt to new business requirements due to mergers and acquisitions and cooperations between enterprises. This certainly leads to integration efforts, i.e. joining different subsystems into a cohesive whole in order to provide new functionality. In such an environment. the application of industrial methods for software development seems even more important. Unfortunately, software development in this field is a highly complex and heterogeneous undertaking, as IT environments differ from customer to customer. In such settings, existing industrialization concepts would never break even due to one-time projects and thus insufficient economies of scale and scope. This present thesis, therefore, describes a novel approach for a more efficient implementation of prior key principles while considering the characteristics of software development for systems integration. After identifying the characteristics of the field and their affects on currently-known industrialization concepts, an organizational model for industrialized systems integration has thus been developed. It takes software product lines and adapts them in a way feasible for a systems integrator active in several business domains. The result is a three-tiered model consolidating recurring activities and reducing the efforts for individual product lines. For the implementation of component-based development, the present thesis assesses current component approaches and applies an integration metamodel to the most suitable one. This ensures a common understanding of systems integration across different product lines and thus alleviates component reuse, even across product line boundaries. The approach is furthermore aligned with the organizational model to depict in which way component-based development may be applied in industrialized systems integration. Automating software development in systems integration with model-driven engineering was found to be insufficient in its current state. The reason herefore lies in insufficient tool chains and a lack of modelling standards. As an alternative, an XML-based configuration of products within a software product line has been developed. It models a product line and its products with the help of a domain-specific language and utilizes stylesheet transformations to generate compliable artefacts. The approach has been tested for its feasibility within an exemplarily implementation following a real-world scenario. As not all aspects of industrialized systems integration could be simulated in a laboratory environment, the concept was furthermore validated during several expert interviews with industry representatives. Here, it was also possible to assess cultural and economic aspects. The thesis concludes with a detailed summary of the contributions to the field and suggests further areas of research in the context of industrialized systems integration

Surfactant protein a in cystic fibrosis: supratrimeric structure and pulmonary outcome.

The state of oligomerization of surfactant associated protein-A (SP-A) monomers differs between individuals. This likely affects SP-A's functional properties and could thereby influence clinical status in patients with lung diseases. In this study we focus on SP-A structure in cystic fibrosis (CF) compared to both healthy subjects and disease controls. SP-A composition and function were assessed in both bronchoalveolar lavage (BAL) fluid and serum of 46 CF patients with mild disease, 25 patients with chronic bronchitis and 22 healthy subjects by gel chromatography and a functional agglutination assay. Relation of SP-A agglutination ability to disease severity of the subjects was explored. SP-A was present in seven major oligomeric forms with the majority of SP-A being structurally organized as complex oligomeric forms. More complex oligomeric forms were associated with better SP-A function with regard to its agglutination ability. These forms were more frequently observed in BAL than in serum, but there were no differences between disease groups. In CF patients, more complex forms of SP-A were associated with better lung function. Organizational structure of SP-A affects its functional activity and is linked to disease severity in CF

A continuous approach to Floquet theory for pulse-sequence optimization in solid-state NMR

We present a framework that uses a continuous frequency space to describe and design solid-state NMR experiments. The approach is similar to the well established Floquet treatment for NMR, but is not restricted to periodic Hamiltonians and allows the design of experiments in a reverse fashion. The framework is based on perturbation theory on a continuous Fourier space, which leads to effective, i.e., time-independent, Hamiltonians. It allows the back calculation of the pulse scheme from the desired effective Hamiltonian as a function of spin-system parameters. We show as an example how to back calculate the rf irradiation in the MIRROR experiment from the desired chemical-shift offset behaviour of the sequence

CAIR: Using Formal Languages to Study Routing, Leaking, and Interception in BGP

The Internet routing protocol BGP expresses topological reachability and policy-based decisions simultaneously in path vectors. A complete view on the Internet backbone routing is given by the collection of all valid routes, which is infeasible to obtain due to information hiding of BGP, the lack of omnipresent collection points, and data complexity. Commonly, graph-based data models are used to represent the Internet topology from a given set of BGP routing tables but fall short of explaining policy contexts. As a consequence, routing anomalies such as route leaks and interception attacks cannot be explained with graphs. In this paper, we use formal languages to represent the global routing system in a rigorous model. Our CAIR framework translates BGP announcements into a finite route language that allows for the incremental construction of minimal route automata. CAIR preserves route diversity, is highly efficient, and well-suited to monitor BGP path changes in real-time. We formally derive implementable search patterns for route leaks and interception attacks. In contrast to the state-of-the-art, we can detect these incidents. In practical experiments, we analyze public BGP data over the last seven years

Pervasive Gaming: Testing Future Context Aware Applications

Over the last few years, many discussions have centred around the issue of interconnection rates and their economic impact on the market. Interconnection charging in Europe is still based mainly on the calling party pays (CPP) principle combined with element based charging (EBC). Due to the convergence of the classical PSTN/ISDN and the IP world to next generation networks (NGN), the different charging principles and systems are being reviewed to determine the optimal solution for the future. In its working program for the year 2008, the Austrian Regulatory Authority (RTR) launched an industry working group on charging principles and systems for wholesale services. This paper highlights some of the central issues of the discussions that have taken place and contains the authors’ views and conclusions .1 Further, the paper identifies possible charging systems, as well as economic assessment criteria for these systems and how the different charging systems may be evaluated with respect to those criteria. Regarding the usefulness of industry working groups, the work has shown that these lead to a higher degree of transparency between regulator and market players as well as a better understanding between the market players themselves. The main drawback is that working groups are time consuming and that it is almost impossible to agree on meaningful outcomes. Regarding the assessment of the charging models it was possible to derive a set of 10 criteria according to which charging systems can be evaluated. There was a rather broad consensus on the delineation of charging models as well as the economic criteria. When it comes to the results of the evaluation, the discussions brought forward very controversial views amongst the participants. No common views could be achieved on which the charging model fulfills the defined criteria in the best manner.Interconnection, NGN, charging principles, CPP, Bill&Keep.

Numerical analysis of a transmission problem with Signorini contact using mixed-FEM and BEM

© EDP Sciences, SMAI 2011This paper is concerned with the dual formulation of the interface problem consisting of a linear partial differential equation with variable coefficients in some bounded Lipschitz domain Ω in Rn (n ≥ 2) and the Laplace equation with some radiation condition in the unbounded exterior domain Ωc := Rn\￣Ω. The two problems are coupled by transmission and Signorini contact conditions on the interface Γ = ∂Ω. The exterior part of the interface problem is rewritten using a Neumann to Dirichlet mapping (NtD) given in terms of boundary integral operators. The resulting variational formulation becomes a variational inequality with a linear operator. Then we treat the corresponding numerical scheme and discuss an approximation of the NtD mapping with an appropriate discretization of the inverse Poincar´e-Steklov operator. In particular, assuming some abstract approximation properties and a discrete inf-sup condition, we show unique solvability of the discrete scheme and obtain the corresponding a-priori error estimate. Next, we prove that these assumptions are satisfied with Raviart- Thomas elements and piecewise constants in Ω, and continuous piecewise linear functions on Γ. We suggest a solver based on a modified Uzawa algorithm and show convergence. Finally we present some numerical results illustrating our theory

Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?

Inflammation is an important environmental factor that promotes tumourigenesis and the progression of established cancerous lesions, and recent studies have started to dissect the mechanisms linking the two pathologies. These inflammatory and infectious conditions trigger immune and stromal cell release of soluble mediators which facilitate survival and proliferation of tumour cells in a paracrine manner. In addition, (epi-)genetic mutations affecting oncogenes, tumour-suppressor genes, chromosomal rearrangements and amplifications trigger the release of inflammatory mediators within the tumour microenvironment to promote neoplastic growth in an autocrine manner. These two pathways converge in tumour cells and result in activation of the latent signal transducer and activator of transcription 3 (Stat3) which mediates a transcriptional response favouring survival, proliferation and angiogenesis. The abundance of cytokines that activate Stat3 within the tumour microenvironment, which comprises of members of the interleukin (IL) IL6, IL10 and IL17/23 families, underpins a signaling network that simultaneously promotes the growth of neoplastic epithelium, fuels inflammation and suppresses the host's anti-tumour immune response. Accordingly, aberrant and persistent Stat3 activation is a frequent observation in human cancers of epithelial origin and is often associated with poor outcome