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    Charge Transfer through Modified Peptide Nucleic Acids

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    We studied the charge transfer properties of bipyridine-modified peptide nucleic acid (PNA) in the absence and presence of ZnĀ­(II). Characterization of the PNA in solution showed that ZnĀ­(II) interacts with the bipyridine ligands, but the stability of the duplexes was not affected significantly by the binding of ZnĀ­(II). The charge transfer properties of these molecules were examined by electrochemistry for self-assembled monolayers of ferrocene-terminated PNAs and by conductive probe atomic force microscopy for cysteine-terminated PNAs. Both electrochemical and single molecular studies showed that the bipyridine modification and ZnĀ­(II) binding do not affect significantly the charge transfer of the PNA duplexes
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