Charge Transfer through
Modified Peptide Nucleic Acids
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Abstract
We studied the charge transfer properties of bipyridine-modified
peptide nucleic acid (PNA) in the absence and presence of Zn(II).
Characterization of the PNA in solution showed that Zn(II) interacts
with the bipyridine ligands, but the stability of the duplexes was
not affected significantly by the binding of Zn(II). The charge transfer
properties of these molecules were examined by electrochemistry for
self-assembled monolayers of ferrocene-terminated PNAs and by conductive
probe atomic force microscopy for cysteine-terminated PNAs. Both electrochemical
and single molecular studies showed that the bipyridine modification
and Zn(II) binding do not affect significantly the charge transfer
of the PNA duplexes