Hearing and dementia

Hearing deficits associated with cognitive impairment have attracted much recent interest, motivated by emerging evidence that impaired hearing is a risk factor for cognitive decline. However, dementia and hearing impairment present immense challenges in their own right, and their intersection in the auditory brain remains poorly understood and difficult to assess. Here, we outline a clinically oriented, symptom-based approach to the assessment of hearing in dementias, informed by recent progress in the clinical auditory neuroscience of these diseases. We consider the significance and interpretation of hearing loss and symptoms that point to a disorder of auditory cognition in patients with dementia. We identify key auditory characteristics of some important dementias and conclude with a bedside approach to assessing and managing auditory dysfunction in dementia

Effect of absorbed hydrogen on crack-tip ductility in the welded A516 steel

Effects of absorbed hydrogen on structure and properties of welded A516 Grade-70 steel are investigated. Emphasis is placed on ductility measure of the crack-tip plastic zone under Mode I loading. Specimens are cathodically charged in a cell with dilute sulphuric acid and corrosion inhibitor with uniform charging current density of 20 mA/ cm2 and at different exposure time. Results indicate a change from coarse- to fine-grained microstructures in the weld region and heat affected zone (HAZ) of hydrogen-charged specimen. Well-defined ferrite-pearlite bands in the base metal are transformed into coarse-grain structure. Hardness variation along radial distance indicates higher values towards the center of the bar, possibly due to faster diffusion rate but limited solubility of hydrogen. Load-COD responses indicate that slow, stable crack propagation occurred in both base metal and HAZ. The measured provisional fracture toughness, KQ is higher for HAZ than that for the base metal. The toughness values decreases significantly for the initial three hours of hydrogen charging. The tensile fracture region in the immediate fatigue pre-crack tip forms a triangular (rough) zone due to limited constraint to free surface deformation in the thin specimen. Fracture surface of HAZ is dominated by intergranular fracture with localized cleavage facets

SIMULATION OF POROSITY AND PTFE CONTENT IN GAS DIFFUSION LAYER ON PROTON EXCHANGE MEMBRANE FUEL CELL PERFORMANCE

Numerous research and development activities have been conducted to optimize the operating parameters of a proton exchange membrane fuel cell (PEMFC) by experiments and simulations. This study explains the development of a 3D model by using ANSYS FLUENT 14.5 to determine the optimum PEMFC parameters, namely, porosity and polytetrafluoroethylene (PTFE) content, in the gas diffusion layer (GDL). A 3D model was developed to analyze the properties and effects of GDL. Simulation results showed that the increase in GDL porosity significantly improved the performance of PEMFC in generating electrical power. However, the performance of PEMFC decreased with increasing PTFE content in GDL. Thus, the PTFE content in the GDL must be optimized and the optimum PTFE content should be 5 wt%. The model developed in this simulation showed good capability in simulating the PEMFC parameters to assist the development process of PEMFC design

Comparative studies of physicochemical properties of sweet potato (Ipomoea batatas) cookies from different variations of sweet potato

Sweet potato possesses superb nutritional values and it grows easily in a hot and humid climate. In Malaysia, sweet potatoes are commonly used in making traditional snacks and sweet desserts despite that sweet potato has greater potential for utilization in other new food products. This study was conducted to formulate cookies with partial substitution of wheat flour with orange-flesh (VitAto) or purple-fleshed (Anggun) sweet potatoes. The cookies were prepared from the formulation blend of sweet potato and wheat flour in the substitution levels of 20% and 40%, respectively. The proximate composition and physicochemical properties of the formulated cookies were studied. The proximate analysis results depicted that, compared to the control cookies, sweet potato incorporated cookies had higher moisture, ash, and carbohydrates contents but lower crude protein and crude fat. The cookies incorporated with sweet potato presented a significantly greater spread ratio and diameter than the control. The results of texture profile analysis indicated that partial substitution of sweet potato for wheat flour significantly decreased the hardness of cookies though it had zero effect on the attribute of springiness. These findings revealed that the sweet potato has positive potential uses in the development of cookies or other bakery products with enhanced nutritional quality

DiMeLo-seq: a long-read, single-molecule method for mapping protein-DNA interactions genome wide.

Studies of genome regulation routinely use high-throughput DNA sequencing approaches to determine where specific proteins interact with DNA, and they rely on DNA amplification and short-read sequencing, limiting their quantitative application in complex genomic regions. To address these limitations, we developed directed methylation with long-read sequencing (DiMeLo-seq), which uses antibody-tethered enzymes to methylate DNA near a target protein's binding sites in situ. These exogenous methylation marks are then detected simultaneously with endogenous CpG methylation on unamplified DNA using long-read, single-molecule sequencing technologies. We optimized and benchmarked DiMeLo-seq by mapping chromatin-binding proteins and histone modifications across the human genome. Furthermore, we identified where centromere protein A localizes within highly repetitive regions that were unmappable with short sequencing reads, and we estimated the density of centromere protein A molecules along single chromatin fibers. DiMeLo-seq is a versatile method that provides multimodal, genome-wide information for investigating protein-DNA interactions