Beam heat load and pressure rise in a cold vacuum chamber

The beam heat load and the pressure in the vacuum chamber of the cold bore superconducting undulator installed at ANKA (ANgstrom source KArlsruhe) have been monitored for almost two years. Possible sources of the observed heat load could be synchrotron radiation from upstream magnets, image currents, electron and ion bombardment. In this paper, the various possible contributions to the heat load are discussed and compared with experimental results. The dynamic pressure increases nonlinearly with the average beam current. The current where it assumes a maximum varies both with the bunch intensity and with the initial vacuum pressure. A correlation between the heat load and the dynamic pressure has been observed. This study suggests that electron bombardment could explain the beam heat load and pressure rise observed for a bunch length of 10 mm

Beam heat load and pressure rise in a could vacuum chamber

The beam heat load and the pressure in the vacuum chamber of the cold bore superconducting undulator installed at ANKA (ANgstrom source KArlsruhe) have been monitored for almost two years. Possible sources of the observed heat load could be synchrotron radiation from upstream magnets, image currents, electron and ion bombardment. In this paper, the various possible contributions to the heat load are discussed and compared with experimental results. The dynamic pressure increases nonlinearly with the average beam current. The current where it assumes a maximum varies both with the bunch intensity and with the initial vacuum pressure. A correlation between the heat load and the dynamic pressure has been observed. This study suggests that electron bombardment could explain the beam heat load and pressure rise observed for a bunch length of 10 mm

Observation of Electron Clouds in the ANKA Undulator by Means of the Microwave Transmission Method

A superconducting undulator is installed in the ANKA electron storage ring. Electron clouds could potentially contribute to the heat load of this device. A microwave transmission type electron cloud diagnostic has been installed for the undulator section of the ANKA machine. We present the system layout with particular emphasis on the electron machine aspects. Hardware transfer function results and e-cloud data for different machine settings are discussed. Special care has been taken for front end filter design both on the microwave injection and pick-up side

Genotypic variability of Pinus sylvestris L. on the drought-resistance attribute

There was an increase and intensification of droughts in connection with global climate change in recent decades. Not all plant organisms are able to adapt to changing environmental conditions. Therefore, the question of stressresistant (drought-resistant) genotypes selection for breeding is quite urgent. This problem also concerns forest tree plants, including Scots pine, which is one of the main foresters in the Voronezh region. The results of vegetative and generative sphere analysis of individual Scotch pine trees with the help of biotechnology, molecular-genetic and cytogenetic method are given in this study. The possibility of applying the tissue culture method in vitro for testing initial plants for stress resistance, including drought resistance, is explained by the interconnection of cells, tissues and the whole plant properties. It is shown that the cytogenetic characteristics of the seed progeny and the indicators of callusogenic reactions do not always coincide in different genotypes: in some cases energy resources are spent on ontogeny protection, while, in other cases, to reproductive function maintain. There are trees, in which the state the generative sphere in arid years is at the level of optimal years, and their callus cultures reaction remains unchanged even under simulated conditions of drought. Based on the results obtained for the selection of Scots pine drought-resistant genotypes we suggest applying a system of criteria characterizing both the ability of the vegetative sphere to survive in drought conditions on the basis of the tissue culture method in vitro (callus tissue formation speed, its viability, frequency of callusogenesis), and the state of the generative sphere with the help of cytogenetic analysis of seed progeny (frequency of mitosis pathologies, the proportion of cells with micronuclei, mitotic activity). The expediency of applying the biotechnological approach was proved by analysis of the gene expression level of stress proteins: the level of AbaH gene expression correlates greatly with the indicator of the viability of callus cultures, including ones on a nutrient medium with an additional stress agent (NaCl). Trees that can be assigned to drought-resistant ones, according to the results of the analysis, should be recommended for use in breeding

Interleukin-18 gene polymorphism in pregnancy With premature rupture of membranes: A case-control study

Background. Imbalanced pro- and anti-inflammatory systems can unfavourably condition carrying of pregnancy and provoke gestation complications, such as premature rupture of membranes.Objectives. Assessing the contribution of SNP variants -137G>C (rs187238), -607G>T (rs1946518) and -656A>C (rs5744228) of the IL-18 gene promoter to the incidence of extremely preterm premature rupture of membranes.Methods. A case-control study enrolled 120 pregnant women managed at the Perinatal Centre. The women were divided in two cohorts. The study cohort comprised 80 women with premature rupture of membranes at 22–27 weeks 6 days’ gestation hospitalised in a high-risk pregnancy unit, a control cohort consisted of 40 women with physiological pregnancy at 22–27 weeks 6 days’ gestation following outpatient counselling. The cohorts had comparable obstetric and gynaecological histories. The study exclusion criteria were: multiple gestation, foetal chromosomal anomalies, congenital foetal malformations, pregnancy due to assisted reproduction. Genotyping was performed at positions -137G>C, -607G>T and -656A>C of the IL-18 gene promoter with determining a peripheral blood IL-18 level in cohorts.Results. The premature rupture of membranes cohort had a statistically higher serum interleukin-18 concentration compared to control (p = 0.001). Genotyping of the IL-18 gene promoter revealed a statistically higher rate of homozygous -137G>C mutation (CC genotype) in the premature rupture of membranes cohort at 22–27 weeks 6 days’ term (p <0.001), 67 vs. 27% in control.Conclusion. A homozygous IL-18 -137G>C polymorphic variant associated with elevated blood IL-18 levels is statistically more common in pregnant women having premature rupture of membranes at 22–27 weeks 6 days’ gestation

Functional expression of SCN5A mutation R1628Q associated with Brugada syndrome

目的 体外构建含R1628Q突变的人心脏钠离子通道α亚基真核表达载体pHL-hH1-R1628Q。研究R1628Q突变对钠通道电生理性质的影响，阐明Brugada综合征的发病机制，为疾病的基因诊断和分子治疗提供新的思路。 方法 设计带突变位点的引物，以含有人心脏钠离子通道cDNA的质粒为模板经重叠延伸PCR法体外定点诱变，构建R1628Q突变型人心脏钠离子通道真核表达载体。经酶切和DNA测序验证后与心脏钠离子通道β1亚基质粒pEGFP-N3-SCN1B瞬时共同转染到HEK293，48小时后全细胞记录钠通道的电生理特性。 结果 1.DNA测序证实突变质粒pHL-hH1-R1628Q构建...Objective To explore the functional effect of R1628Q mutation on SCN5A,we construct human cardiac sodium channel alpha subunit cDNA(hH1) mutated recombinant pHL-hH1-R1628Q via site-directed mutagenesis in vitro, and study the current and electrophysiological properties of the sodium channel using patch-clamp whole-cell recording in HEK293 cell into which the hH1-WT or hH1-R1628Q is transfected. T...学位：医学硕士院系专业：医学院_内科学学号：2452010115328

The Method of Information Value Estimation Using Fuzzy Logic Tools

The paper contains the description of the method of information objects value estimation when analyzing the information security risk using fuzzy logic tools. The value of information, processed within the network segment, is estimated according to the quantity of the protected information objects and the number of possible types of information security breach consequences

The Threats Model Construction by means of Fuzzy Cognitive Map on the basis of the Networks Security Policy

The threats matrix construction on the basis of the access matrixes is discussed. Development of threats model on the basis of fuzzy cognitive maps displaying the threats spreading pathways from attack sources to objects is described