Characteristics And Survival Of Aids Patients With Hepatitis C: The Brazilian National Cohort Of 1995-1996.

As AIDS patients live longer, the management of co-morbidities becomes increasingly important. Previous studies from developed countries give conflicting results as to whether co-infection with hepatitis C virus (HCV) lowers the life expectancy of individuals with AIDS. This retrospective cohort study was based on a medical record review of a nationally representative sample of 2821 adult AIDS cases diagnosed in 1995 and 1996 in Brazil. We compared the characteristics and survival of patients known to be positive and negative for HCV. A total of 833 patients received HCV testing, and the prevalence was 33%. HCV-positive patients received less intensive antiretroviral treatment. The crude mortality was greater for HCV-positive patients (hazard ratio 1.26; P = 0.04), but HCV status was not a significant predictor in a multivariate analysis that included other predictors of survival. Brazilian AIDS patients with hepatitis C have a shorter survival than those without, but this seems to be mainly as a result of their receiving less antiretroviral treatment. We cannot say whether this is because of the fear of hepatotoxicity, an inability to tolerate treatment, or for other reasons. To improve survival, these patients need optimal treatment of their HIV disease.19 Suppl 4S27-3

New variant of Creutzfeldt-Jakob (vCJD) disease and other human prion diseases under epidemiological surveillance in Brazil

Abstract To increase the timeliness of detection of human cases of the new variant of Creutzfeldt-Jakob disease (vCJD) and to reduce the risk of transmission, the Brazilian Ministry of Health has established and standardized rules and control measures. These include the definition of criteria for suspect cases, reporting, monitoring, and control measures for illness prevention and transmission. Guidelines to be used by the team of health care staff were published and distributed to health workers. A detailed proposal for a simplified system of surveillance for prion diseases was developed and mandatory reporting introduced. Additional effort is necessary to increase vCJD case detection, thus making it necessary to establish a partnership with health care services for best identification of suspected cases and dissemination of information to all involved in the service dealing with vCJD investigation

AIDS research in Brazil

Made available in DSpace on 2010-08-23T16:58:40Z (GMT). No. of bitstreams: 3 license.txt: 1841 bytes, checksum: d3d3e367e425edc38f8fe2a68d175909 (MD5) Bastos_AIDS Research in Brazil_2005.pdf: 46976 bytes, checksum: f5f3107c4d9709e92ba9a190879f2f02 (MD5) Bastos_AIDS Research in Brazil_2005.pdf.txt: 11342 bytes, checksum: 729de25e7cf733419d12bf5ed8ce6ebf (MD5) Previous issue date: 2005Made available in DSpace on 2010-11-04T14:19:42Z (GMT). No. of bitstreams: 3 Bastos_AIDS Research in Brazil_2005.pdf.txt: 11342 bytes, checksum: 729de25e7cf733419d12bf5ed8ce6ebf (MD5) Bastos_AIDS Research in Brazil_2005.pdf: 46976 bytes, checksum: f5f3107c4d9709e92ba9a190879f2f02 (MD5) license.txt: 1841 bytes, checksum: d3d3e367e425edc38f8fe2a68d175909 (MD5) Previous issue date: 2005Brazilian National STI/AIDS Control Program. Brasilia, DF, Brazil.Brazilian National STI/AIDS Control Program. Brasilia, DF, Brazil.Brazilian National STI/AIDS Control Program. Brasilia, DF, Brazil.Miguel Hernandez University. Alicante, Spain.Fundação Oswaldo Cruz. Centro Informação Científica e Tecnológica. Departamento de Informações para a Saúde. Rio de Janeiro, RJ, BrasilUniversity of São Paulo. São Paulo, SP, Brazil.University of California. San Francisco, CA, USA