Clinical Features and Inflammatory Markers in Autoimmune Encephalitis Associated With Antibodies Against Neuronal Surface in Brazilian Patients

Acute encephalitis is a debilitating neurological disorder associated with brain inflammation and rapidly progressive encephalopathy. Autoimmune encephalitis (AE) is increasingly recognized as one of the most frequent causes of encephalitis, however signs of inflammation are not always present at the onset which may delay the diagnosis. We retrospectively assessed patients with AE associated with antibodies against neuronal surface diagnosed in reference centers in Northeast of Brazil between 2014 to 2017. CNS inflammatory markers were defined as altered CSF (pleocytosis >5 cells/mm3) and/or any brain parenchymal MRI signal abnormality. Thirteen patients were evaluated, anti-NMDAR was the most common antibody found (10/13, 77%), followed by anti-LGI1 (2/13, 15%), and anti-AMPAR (1/13, 7%). Median time to diagnosis was 4 months (range 2–9 months). Among these 13 patients, 6 (46.1%) had inflammatory markers and when compared to those who did not present signs of inflammation, there were no significant differences regarding the age of onset, time to diagnosis and modified Rankin scale score at the last visit. Most of the patients presented partial or complete response to immunotherapy during follow-up. Our findings suggest that the presence of inflammatory markers may not correlate with clinical presentation or prognosis in patients with AE associated with antibodies against neuronal surface. Neurologists should be aware to recognize clinical features of AE and promptly request antibody testing even without evidence of inflammation in CSF or MRI studies

Revisão de pares cranianos com ênfase em neurologia infantil

In health education, pedagogical processes must meet the needs of A qualified professional, up to date with the newest knowledge in his area of ??expertise and Critical thinking to do the best for the society in which it is embedded. Within this approach, the training units of health professionals have a large Responsibility, not only with the development of undergraduate and graduate programs Appropriate to the national reality, as well as Continuing education programs so that these health professionals continue to be Qualified staff. For the formation of the health professional, especially the physician, a bibliographic review Complete on relevant and routine subjects, is essential, helping in daily practice and With this in mind, a treaty in neuropediatrics with a Updated review of key issues in this area. The dissemination throughout Brazil of a Complete and up-to-date on cranial nerves, with an emphasis on children's neurology, besides being Pioneer in the country, assists in the diffusion of knowledge. Once these objectives have been achieved, Contribute to the practice of prevention of neurological disorders, as well as assisting in the Treatment, recovery and due referrals of patients in need.Na educação para a saúde, os processos pedagógicos devem corresponder às necessidades de um profissional habilitado, atualizado com o mais novo conhecimento na sua área de atuação e voltado com o pensamento crítico para fazer o melhor para a sociedade na qual está inserido. Dentro desse enfoque, as unidades formadoras dos profissionais de saúde têm uma grande responsabilidade, não apenas com o desenvolvimento de programas de graduação e pós-graduação que formem recursos humanos adequados à realidade nacional, assim como na manutenção de programas de educação continuada para que esses profissionais de saúde continuem a ser qualificados. Para a formação do profissional de saúde, em especial o médico, uma revisão bibliográfica completa sobre temas relevantes e rotineiros , é fundamental, auxiliando na prática diária e nas tomadas de decisões, pensando nisso está sendo elaborado um tratado em neuropediatria com uma revisao atualizada dos principais temas nesta área. A difusão por todo o Brasil de uma revisão completa e atualizada sobre pares cranianos, com ênfase em neurologia infantil, além de ser pioneiro no país, auxilia na difusão de conhecimentos. Esses objetivos uma vez alcançados, também contribuirão para a prática da prevenção das afecções neurológicas, assim como ajudarão no tratamento, recuperação e devidos encaminhamentos dos pacientes necessitados.Dados abertos - Sucupira - Teses e dissertações (2013 a 2016