5 research outputs found
Apathy in amyotrophic lateral sclerosis: insights from Dimensional Apathy Scale
<p><i>Objectives</i>: Apathy is associated with cognitive decline and worse survival in amyotrophic lateral sclerosis (ALS); an accurate evaluation of this aspect is relevant in clinical settings. The aims of this study are to evaluate the prevalence of apathy in a large ALS sample, using published diagnostic criteria, and to explore the psychometric properties, the sensitivity and the specificity of the Dimensional Apathy Scale (DAS) as a screening tool for apathy.</p> <p><i>Methods</i>: One hundred and thirty-one patients underwent clinical interview based on diagnostic criteria for apathy, DAS, Apathy Evaluation Scale, and assessment of depression, global cognitive functioning, and non-verbal intelligence.</p> <p><i>Results</i>: According to diagnostic criteria, apathy occurred in 28.2% of the patients. The DAS showed high consistency, convergent, and discriminant validities. Apathetic and non-apathetic patients significantly differed on total DAS and executive and Behavioral/Cognitive Initiation subscales, indicating good criterion validity. Receiver operating characteristics analysis, considering diagnostic criteria for apathy as gold standard, revealed that a score of 26/27 was an optimal cut-off score for the identification of apathy.</p> <p><i>Conclusions</i>: The DAS is a valid screening tool for apathy and its aspects in ALS through limiting the impact of physical disability. Executive and behavioral/cognitive aspects of apathy, rather than emotional aspects, are more frequent in ALS.</p
Detailed patients and controls characteristics.
<p>*available in 39 patients (i.e., 13 patients in stage 2A, 14 in stage 2B and 12 in stage 3)</p><p>Detailed patients and controls characteristics.</p
VBM results in 2A and 2B subsets compared to healthy controls.
<p>ALS patients in stage 2A show GM atrophy (p<0.001, uncorrected) in the right and left precentral gyri, left inferior frontal gyrus, right anterior cingulate, right medial frontal gyrus, left superior temporal gyrus, left parahippocampal gyrus and right insula (left panels). ALS patients in stage 2B exhibit GM atrophy (p<0.001, uncorrected) only in the left inferior frontal gyrus and right cuneus (right panels).</p
Voxel-wise correlation analyses between ALSFRS-R and ACE-R scores and FA in the three groups of patients.
<p>Widespread patterns of positive correlations (p<0.05, corrected) between both disability scores and FA in all clinical stages examined, with overlaps between the three patients groups.</p
Neuropsychological assessment in different King's clinical stages of amyotrophic lateral sclerosis
<p>Emerging evidence shows that cognitive deficits associated with frontal lobe dysfunction occur from early stages of amyotrophic lateral sclerosis (ALS). We aimed to assess neuropsychological functioning at different stages of ALS to further delineate the occurrence of cognitive impairment alongside the trajectory of ALS as defined by standard assessment procedures. We investigated several cognitive domains in 74 ALS patients classified into four different clinical stages of disease, according to a recently validated staging system for ALS (known as ‘King's’ system), and evaluated and compared the corresponding cognitive profiles. We found that data derived from global cognitive assessment and several executive (i.e. Frontal Assessment Battery and Trail Making Test B-A) and long-term memory (i.e. memory prose) tests were significantly different among the subsets of ALS patients, showing poorer performances with increasing clinical disability. In conclusion, our preliminary results support the notion that mainly frontotemporal abilities may be impaired during the ALS course and suggest that neuropsychological information could supplement the current clinical staging of patients. However, ALS-specific multi-domain screening instruments, which allow to correct neuropsychological scores for physical disability, should be validated in larger populations worldwide and routinely introduced in clinical practice.</p