Modelling the Modal Shift Effects of Converting a General Traffic Lane into a Dedicated Bus Lane

This paper presents an analytical framework for evaluating the performance of dedicated bus lanes. It assumes that under a designated travel demand, the traffic volume on a corridor changes with the modal shifts. The modal shift affects the operations of both bus traffic and car traffic and eventually, an equilibrium bus share ratio that maximizes the performance of the corridor will be reached. Microsimulation modelling is employed to assess the traffic operations under various demand levels and bus share ratios. The results show that converting a general lane into a bus lane significantly reduces bus delay. For car traffic, the overall trend is that delay increases after converting a general lane to a bus lane. In addition, delay decreases with the increase of bus share ratio. Nevertheless, when bus share ratio reaches 0.6 (demand less than 10,000 passengers per hour, pph; or 0.8 when demand increases up to 14,000 pph), there is no significant difference in delay between the two scenarios. The identified bus share ratios have the potential to direct the development of bus lane warrants. Finally, this research recommends that the Transportation Demand Management (TDM) strategies shall be developed to stimulate the modal shifts towards the identified optimal bus share ratio.</p

Cement Improved Highly Weathered Phyllite for Highway Subgrades: A Case Study in Shaanxi Province.

In a cost-saving move, the soft rocks composed of highly-weathered phyllites available onsite were used to fill the subgrade in the eastern Ankang section of the expressway of Shiyan to Tianshui, China. Cement admixture was used to improve the performance of the weathered phyllites. In order to determine the best mix ratio, values corresponding to compaction performance, unconfined compressive strength, and the California bearing ratio (CBR) were analyzed for variable cement content weight percentages (3%, 4%, 5%, and 6%) using test subgrade plots in the field. Field measurements of resilience modulus and deflection confirmed that the strength of the subgrade increased as the cement ratio increased. In order to further evaluate the cement/phyllite mixture, the performance of the 3% cement ratio sample was evaluated under saturated conditions (with various levels of moisture addition and soaking time) using both the wetting deformation and resilient modulus values. Results suggest that moisture added and soaking time are key factors that affect the seepage depth, water content, and resilient modulus. The recommend values for the cement addition and for the water content are given out. This study can aid in prevention of highway damage by improving the foundation capacity and lengthening the lifecycle of the highway in phyllite distributed region at home and abroad

Experimental Study of Soil Water Migration in Freezing Process

Soil water migration is a significant factor in the development of subgrade ice layers in permafrost areas. The prediction of moisture inflow to the freezing zone is an important element in the design and analysis of robust highway subgrade in permafrost regions. In order to better understand moisture inflow to the freezing zone, we designed an experimental investigation to monitor the variation of water content and temperature in freezing soil. Identical experiments were conducted using three different soil types: clay, silt, and fine sand. Moisture was supplied from the sample base while the column was maintained at a constant nonfreezing temperature and moisture equilibration was achieved. A temperature gradient was then applied to the sample via the application of a subfreezing temperature at the column surface. The changes in the temperature and water content of the sample were measured at regular time intervals. Based on the freezing rate, the freezing process can be classified into three stages: the quick frost stage, the transition frost stage, and the stable frost stage. During the freezing process, the inflow rates increased as the thickness of the ice lens increased. When the maximum rate was reached, the final (maximum) thickness of the ice lens was attained. Subsequently, the water inflow rates decreased. All of the water supplied from the bottom of the sample flowed into the frost section during the freezing process, with the moisture contents in the lower portion remaining relatively unchanged. The segregation potential changed with the freezing rate and soil type. This paper proposes the concept of “generalized segregation potential” to extend the traditional segregation potential concept. The use of this new concept with an existing moisture inflow prediction model provided excellent correspondence to measured inflow rates for all three study soils in the early and late stages of the test but overpredicted the inflow rates in the mid-range of the test

More comprehensive facial inversion for more effective expression recognition

Facial expression recognition (FER) plays a significant role in the ubiquitous application of computer vision. We revisit this problem with a new perspective on whether it can acquire useful representations that improve FER performance in the image generation process, and propose a novel generative method based on the image inversion mechanism for the FER task, termed Inversion FER (IFER). Particularly, we devise a novel Adversarial Style Inversion Transformer (ASIT) towards IFER to comprehensively extract features of generated facial images. In addition, ASIT is equipped with an image inversion discriminator that measures the cosine similarity of semantic features between source and generated images, constrained by a distribution alignment loss. Finally, we introduce a feature modulation module to fuse the structural code and latent codes from ASIT for the subsequent FER work. We extensively evaluate ASIT on facial datasets such as FFHQ and CelebA-HQ, showing that our approach achieves state-of-the-art facial inversion performance. IFER also achieves competitive results in facial expression recognition datasets such as RAF-DB, SFEW and AffectNet. The code and models are available at https://github.com/Talented-Q/IFER-master

A living biobank of matched pairs of patient-derived xenografts and organoids for cancer pharmacology

Patient-derived tumor xenograft (PDX)/organoid (PDO), driven by cancer stem cells (CSC), are considered the most predictive models for translational oncology. Large PDX collections reflective of patient populations have been created and used extensively to test various investigational therapies, including population-trials as surrogate subjects in vivo. PDOs are recognized as in vitro surrogates for patients amenable for high-throughput screening (HTS). We have built a biobank of carcinoma PDX-derived organoids (PDXOs) by converting an existing PDX library and confirmed high degree of similarities between PDXOs and parental PDXs in genomics, histopathology and pharmacology, suggesting “biological equivalence or interchangeability” between the two. Here we demonstrate the applications of PDXO biobank for HTS “matrix” screening for both lead compounds and indications, immune cell co-cultures for immune-therapies and engineering enables in vitro/in vivo imaging. This large biobank of >550 matched pairs of PDXs/PDXOs across different cancers could become powerful tools for the future cancer drug discovery

Revisiting the HD 21749 planetary system with stellar activity modelling

HD 21749 is a bright (V = 8.1 mag) K dwarf at 16 pc known to host an inner terrestrial planet HD 21749c as well as an outer sub-Neptune HD 21749b, both delivered by Transiting Exoplanet Survey Satellite (TESS). Follow-up spectroscopic observations measured the mass of HD 21749b to be 22.7 ± 2.2 M with a density of 7.0^{+1.6}_{-1.3} g cm-3, making it one of the densest sub-Neptunes. However, the mass measurement was suspected to be influenced by stellar rotation. Here, we present new high-cadence PFS RV data to disentangle the stellar activity signal from the planetary signal. We find that HD 21749 has a similar rotational time-scale as the planet's orbital period, and the amplitude of the planetary orbital RV signal is estimated to be similar to that of the stellar activity signal. We perform Gaussian process regression on the photometry and RVs from HARPS and PFS to model the stellar activity signal. Our new models reveal that HD 21749b has a radius of 2.86 ± 0.20 R, an orbital period of 35.6133 ± 0.0005 d with a mass of Mb = 20.0 ± 2.7 M and a density of 4.8^{+2.0}_{-1.4} g cm-3 on an eccentric orbit with e = 0.16 ± 0.06, which is consistent with the most recent values published for this system. HD 21749c has an orbital period of 7.7902 ± 0.0006 d, a radius of 1.13 ± 0.10 R, and a 3σ mass upper limit of 3.5 M. Our Monte Carlo simulations confirm that without properly taking stellar activity signals into account, the mass measurement of HD 21749b is likely to arrive at a significantly underestimated error bar

The draft genome of watermelon (Citrullus lanatus) and resequencing of 20 diverse accessions

Watermelon, Citrullus lanatus, is an important cucurbit crop grown throughout the world. Here we report a high-quality draft genome sequence of the east Asia watermelon cultivar 97103 (2n = 2 7 = 22) containing 23,440 predicted protein-coding genes. Comparative genomics analysis provided an evolutionary scenario for the origin of the 11 watermelon chromosomes derived from a 7-chromosome paleohexaploid eudicot ancestor. Resequencing of 20 watermelon accessions representing three different C. lanatus subspecies produced numerous haplotypes and identified the extent of genetic diversity and population structure of watermelon germplasm. Genomic regions that were preferentially selected during domestication were identified. Many disease-resistance genes were also found to be lost during domestication. In addition, integrative genomic and transcriptomic analyses yielded important insights into aspects of phloem-based vascular signaling in common between watermelon and cucumber and identified genes crucial to valuable fruit-quality traits, including sugar accumulation and citrulline metabolism

Analysis of liquid–vapor mixed migration mechanism in unsaturated soil based on the effect of temperature on soil microstructure

Abstract Moisture migration in unsaturated soils is a result of the interaction between temperature and soil microstructure. In order to reveal the mechanism of moisture increase of subgrade soils under diurnal cycle conditions, a series of macro and microscopic tests were carried out on the unsaturated silty clay and sand soil, including liquid–vapor mixed migration tests simulating a one-dimensional subgrade, environmental scanning electron microscope (ESEM), and matrix suction test. Then, the soil microstructure in microscopic images was investigated using the particle (pores) and cracks analysis system (PACS). Next, the relationship between the thermal effects of the soil–water characteristic curve (SWCC) and changes in soil microstructure was analyzed. Finally, the change mechanism of liquid–vapor mixed migration based on the change in soil microstructural under thermal effects was analyzed. The results showed under the diurnal cycle, both the silty clay and sand soil columns appeared in the phenomenon of a “diurnal cycle of water vapor migration”, which led to moisture accumulation at the top of the soil layer. In silty clay soil column, moisture was primarily driven by water vapor pressure and migrated upwards. Additionally, moisture redistribution led to changes in soil microstructure, which in turn influenced the process of moisture migration. The moisture content in the upper soil layer increased making both inter-aggregate and intra-aggregate pores decrease. The moisture content in the lower soil later decreased, leading to the water-holding capacity of the lower soil layer to increase. So, the moisture migration gradually decreased at night. In the sand soil column, moisture migration was mainly driven by gravity potential and migrated downwards. Moisture redistribution made inter-aggregate pore and matrix suction of the upper soil layer increase, leading to an increase in moisture migration at night