Sutter_Barton_et_al_Behav_Ecol_Data

Data on serve speed and accuracy and the outcome of games (win / lose). Information that could identify individual players has been removed, in keeping with archiving guidelines

RawQGSexCombData

Half sib breeding design to estimate the genetic variances and covariance for sex comb traits

RawSexCombFitnessData

Selection on sex combs across several episodes of selection

R. temporaria Final_Denovo Assembly

Final denovo transcriptome assembly. Assembly incorporates all 6 populations and was constructed using TransAbyss

Bacterial Read Classification Counts Table

Table of number of removed reads that mapped to individual bacterial species per sample population library. Read classification was performed using the Kraken classification program

Protein Annotations

List of protein annotations per assembled transcript. Annotations were generated using the Blast+ software package. Using a custom Blast database constructed from Human, Mammalian and Vertebrate Blast databases

SRP131529

Raw RNA-Seq reads available in NCBI at SRP131529

Expression Counts Table

Table of reads per transcript per population sample library as computed using HTSeq

Legislative Documents

Also, variously referred to as: House bills; House documents; House legislative documents; legislative documents; General Court documents

Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite

The dependence of drug potency on diastereomeric configurations is a key facet. Using a novel general divergent synthetic route for a three-chiral center antimalarial natural product cladosporin, we built its complete library of stereoisomers (cladologs) and assessed their inhibitory potential using parasite-, enzyme-, and structure-based assays. We show that potency is manifest via tetrahyropyran ring conformations that are housed in the ribose binding pocket of parasite lysyl tRNA synthetase (KRS). Strikingly, drug potency between top and worst enantiomers varied 500-fold, and structures of KRS-cladolog complexes reveal that alterations at C3 and C10 are detrimental to drug potency whereas changes at C3 are sensed by rotameric flipping of glutamate 332. Given that scores of antimalarial and anti-infective drugs contain chiral centers, this work provides a new foundation for focusing on inhibitor stereochemistry as a facet of antimicrobial drug development