Grafting By Epidermal Scraping In Stable Vitiligo: A Therapeutic Option

Vitiligo is an acquired depigmentation characterized by partial or total loss of epidermal melanocytes. Many therapeutic modalities have been proposed for its treatment. In cases of stable vitiligo surgical treatments are preferred. Grafting by epidermal scraping is a variant of micrografts by punch technique. It is a new, simple and low cost technique, with high rates of repigmentation. The objective of this report is to demonstrate the authors' experience with this technique and discuss the results in an initial series of two cases (three lesions).8217317

Superficial cutaneous lipomatous nevus: Report of a case simulating plane xanthoma [Nevo lipomatoso cutâneo superficial: Relato de um caso simulando xantoma plano]

Made available in DSpace on 2019-09-12T16:32:38Z (GMT). No. of bitstreams: 0 Previous issue date: 2015The authors describe the case of a 54-year-old woman presenting papules and yellowish plaques on the right thigh for 15 years, which clinically resembled a plane xanthoma. An anatomical pathological examination evidenced a mature adipose tissue in the dermis, with a diagnosis of superficial cutaneous lipomatous nevus, a rare benign hamartomatous malformation characterized by the presence of ectopic mature adipocytes in the dermis.de Olveira, A.L.C., Hospital Universitário de Taubaté, Taubaté (SP), BrazilRabay, F.M.O., Universidade de Taubaté (Unitau), Taubaté (SP), BrazilElias, B.L.F., Estagiária do Serviço de Dermatologia do, Hospital Universitário de Taubaté, Taubaté (SP), BrazilLira, M.L.A., Universidade de Taubaté (Unitau), Taubaté (SP), BrazilMandelbaum, S.H., Chefe do Serviço de Dermatologia do Hospital, Universitário de Taubaté, Taubaté (SP), Brazi

Desmoplastic melanoma: A diagnostic challenge [Melanoma Desmoplásico - um desafio diagnóstico]

Made available in DSpace on 2019-09-12T16:32:38Z (GMT). No. of bitstreams: 0 Previous issue date: 2015Desmoplastic melanoma is a rare variant of melanoma characterized by an invasive lesion of spindle cells and varying degrees of desmoplasia. It is more frequent in men of an advanced age having a history of chronic exposure to sunlight. The extremely variable and nonspecific clinical appearance makes it a challenging diagnosis. The authors present an exuberant case of desmoplastic melanoma in an unusual location, with an initial diagnosis of dermatofibrosarcoma.Ferreira, F.R., Dermatologia do Departamento de Medicina, Universidade de Taubaté (Unitau), Taubaté (SP), Brazil, Universitário de Taubaté (HUT), Taubaté (SP), BrazilFerrari, B., Universitário de Taubaté (HUT), Taubaté (SP), BrazilAcedo, L.M.S., Universitário de Taubaté (HUT), Taubaté (SP), BrazilUjihara, J.E.D., Universitário de Taubaté (HUT), Taubaté (SP), BrazilDe Alvarenga Lira, M.L., Patologia do Departamento de Medicina, Universidade de Taubaté (Unitau), Taubaté (SP), BrazilMandelbaum, S.H., Universitário de Taubaté (HUT), Taubaté (SP), Brazil, Departamento de Medicina, Universidade de Taubaté (Unitau), Taubaté (SP), Brazi

Influência do óleo de Copaifera langsdorffii no reparo de ferida cirúrgica em presença de corpo estranho Influence of Copaifera langsdorffii oil on the repair of a surgical wound in the presence of foreign body

A Copaifera langsdorffii é uma leguminosa nativa do Brasil, da qual pode ser extraído um óleo, popularmente conhecido como óleo de copaíba. Este óleo é amplamente utilizado para tratamento de feridas cutâneas por ser reconhecido como antiinflamatório e cicatrizante. Apesar disso, poucas comprovações científicas do verdadeiro efeito terapêutico desta planta medicinal foram produzidas. O objetivo desse trabalho foi avaliar o efeito do tratamento tópico com C. langsdorffii no processo de reparo quando um corpo estranho é o indutor da inflamação. Para isso, 60 camundongos da linhagem BALB/c foram submetidos à incisão cirúrgica linear de 1cm no dorso para realizar o implante de uma lamínula de vidro com 12mm de diâmetro no tecido subcutâneo. Quatro tratamentos para a ferida foram estabelecidos: controle (C) tratado com solução salina estéril, controle veículo (CV) tratado com óleo mineral estéril, tratamento 1 (T1) tratado com diluição (v:v) de óleo mineral estéril e óleo de C. langsdorffii, tratamento 2 (T2) tratado com óleo de C. langsdorffii puro. As avaliações foram realizadas em períodos de tempo pré-determinados (1, 3, 5, 7 e 14 dias). Era possível perceber características da fase proliferativa como a reepitelização, a presença de fibroblastos e a neovascularização, porém os grupos tratados com o óleo (T1 e T2) não apresentavam reepitelização aos três dias. Esses grupos aos 5 e 7 dias apresentavam no exame macroscópico maior intensidade de edema, hiperemia e permanência de crostas. Na microscopia, a reepitelização ainda não estava completa e a crosta era serocelular. Nos grupos C e CV, apesar de discreta, era predominante a presença de mononucleares, enquanto nos grupos T1 e T2 o infiltrado inflamatório era misto e com maior intensidade que nos outros grupos. Quatorze dias depois da incisão cirúrgica, os aspectos macroscópicos dos grupos C e CV eram semelhantes e os grupos T1 e T2, apesar de a ferida estar completamente fechada e sem crostas, a pele desses animais estava espessada e na derme do grupo T2 parecia ter fibrose mais acentuada do que nos outros grupos. Esses resultados demonstraram que o tratamento tópico com óleo de C. langsdorffii prejudicou o processo de reparação normal de ferida na presença de corpo estranho.<br>Copaifera langsdorffii is a Brazilian native leguminosae that produce resin-oil, popularly known as copaíba oil. This oil is used for the treatment of skin wound due to its recognized antiinflammatory and wound healing effects. Despite, its popular use, there are few published data about the therapeutic effect of this medicinal plant. The aim of the study was to evaluate the topic treatment effect of the Copaíba oil on the process of skin repair inflammation induced by a foreign body subcutanously implanted. Sixty BALB/c mice were submitted to a 1cm linear incision and a 12mm circle coverslip was subcutaneously implanted. Four treatments groups were established: control, sterile saline (C); vehicle control, sterile mineral oil, (VC); treatment 1 (T1), mineral oil plus copaiba oil (V/V), and treatment 2 (T2) copaiba oil. The evaluations were performed at pre-determined time points (1, 3, 5, 7 and 14 days). It was possible to find fibroblasts, epithelial cells proliferation, re-epithelization and newly formed blood vessels in all groups, however, all oil treated groups (T1 and T2) did not present re-epithelization at three days post surgical incision. On days 5 and 7, a higher intensity of edema and hyperemia on the groups T1 and T2 was observed, besides that, the T1 and T2 groups presented a serous cellular scab on the wounds that was absent on the C and VC groups. The inflammatory reactions among the groups C and VC showed more mononuclear cells than the T1 and T2 groups that presented a mixed cell patter composed from both mono and polymorphonuclear cells. Although the surgical wounds were re-epithelizaded, in the groups T1 and T2, they were covered by a serous cellular crust and the dermis tissue still presented an intense mononuclear cell inflammatory focus. Fourteen days after of the surgical incision, the gross aspects on groups C and VC were similar and on groups T1 and T2, despite wound to be completely closed and without crusts, the skin those animals was thickened. Furthermore, the dermis on group T2 presented moderate fibrosis, while the other groups presented slightly ones. The results demonstrated that topical treatment with C. langsdorffii oil debilitated the normal process of a wound repair in the presence of a foreign body