Design and Development of Surfactants Based Elastic Vesicular Drug Carrier System containing Antifungal Drug for Ophthalmic Disorder.

The work depicts utility of a novel; surfactants based elastic vesicular drug carrier system (SEVs), for targeting topically applied drug(s) to the posterior segment of the eye. The system comprised span 20 and an edge activator (tween 80). Terbinafine hydrochloride is a synthetic allylamine antifungal with a low molecular weight (327.89 Da.). It is hydrophilic in nature and has high protein binding and a limiting solubilityis expected to show a poor transport across the cornea; hence no ocular formulations are available. It is used to treat ocular mycoses, the second most usual drive of blindness in developing countries. However, its administered poor patient compliance and limited use due to its variable half-life. Therefore, Terbinafine hydrochloride was comprised into a novel sorbitan (spans) based elastic (SEVs) vesicular system with intent to achieve a prolonged and better effect. It was found to be safe in terms of dermal and eye irritation/corrosion tests according to OECD guidelines. Safety was a crucial issue considering that the system is novel (Indian Patent Application 2390/DEL/2008; 1447/DEL/2010) and is completely surfactant based (spans plus edge activators) formulation

Devising an economical water purification unit using bio-adsorbent

Number of techniques are available to purify water, it include reduction, precipitation, ion exchange, electrochemical reduction and reverse osmosis. Most of them involve high capital costs with recurring expenses, which are not suitable for small-scale industries. Bio-technique has attracted the attention due to its effectiveness and environmentally benign nature. In bio techniques, agro wastes may be the potential sources for producing bio-adsorbents, which can be used for improving the quality of west water. Banana peel and Orange peel are also used as adsorbents for purification of water. Using natural resources upto it’s extend and making water palatable and is the need of the hour specially in developing and underdeveloped counties. Present work emphasizes use of banana peel as bio adsorbent in water purification unit. The designed water purification unit shows remarkable result in limits of purification of water

PULSATILE DRUG DELIVERY SYSTEM: AN "USER-FRIENDLY" DOSAGE FORM

In the body under physiological conditions, many vital functions are regulated by transient release of bioactive substances at a specific time and site. Thus, to mimic the function of living systems and in view of emerging chronotherapeutic approaches, which lead to development of pulsatile system that release a therapeutic agent at a rhythm that ideally matches the biological requirement of a given disease therapy. Diseases where a constant drug levels are not preferred, but needs a pulse of therapeutic concentration in a periodic manner and diseases with established oscillatory rhythm in their pathogenesis includes asthma, arthritis, duodenal ulcer, cancer, cardiovascular diseases acts as a push for the development of “Pulsatile Drug Delivery Systems “. In these systems, there is rapid and transient release of a certain amount of drug molecules within a short time-period immediately after a predetermined off release period. Various techniques are available for the pulsatile delivery like pH dependent systems, time dependent systems, etc. Pulsatile drug delivery system providing special and temporal delivery and increasing patient compliance. Pulsatile drug delivery system is defined as the rapid and transient release of certain amount of molecules within a short time period immediately after predetermined off-release periods i.e. lag time. Advantages of the pulsatile drug delivery system are reduced dose frequency; reduce side effects, drug targeting to specific site like colon and many more. Now in market varies technologies of pulsatile drug delivery system like OROS, CODAS etc. are launched by pharmaceutical companies