Rotor and control system loads analysis of the XV-15 with the advanced technology blades

An analysis of the rotor and control system loads of the XV-15 with the Advanced Technology Blades (XV-15/ATB) was conducted to study the effects of modifications designed to alleviate high collective actuator loads encountered during initial flight tests. Rotor loads predictions were correlated with flight data to establish accuracies of the methodology used in the analysis. Control system loads predictions were then examined and were also correlated with flight data. The results showed a significant reduction in 3/rev collective actuator loads of the XV-15/ATB when the control system stiffness was increased and the rotor blade chord balance and tip twist were modified

Optimum design of high speed prop rotors including the coupling of performance, aeroelastic stability and structures

An optimization procedure is developed for the design of high speed prop-rotors to be used in civil tiltrotor applications. The goal is to couple aerodynamic performance, aeroelastic stability, and structural design requirements inside a closed-loop optimization procedure. The objective is to minimize the gross weight and maximize the propulsive efficiency in high speed cruise. Constraints are imposed on the rotor aeroelastic stability in both hover and cruise and rotor figure of merit in hover. Both structural and aerodynamic design variables are used

Fc-mediated pan-sarbecovirus protection after alphavirus vector vaccination

Summary: Group 2B β-coronaviruses (sarbecoviruses) have caused regional and global epidemics in modern history. Here, we evaluate the mechanisms of cross-sarbecovirus protective immunity, currently less clear yet important for pan-sarbecovirus vaccine development, using a panel of alphavirus-vectored vaccines covering bat to human strains. While vaccination does not prevent virus replication, it protects against lethal heterologous disease outcomes in both severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and clade 2 bat sarbecovirus challenge models. The spike vaccines tested primarily elicit a highly S1-specific homologous neutralizing antibody response with no detectable cross-virus neutralization. Rather, non-neutralizing antibody functions, mechanistically linked to FcgR4 and spike S2, mediate cross-protection in wild-type mice. Protection is lost in FcR knockout mice, further supporting a model for non-neutralizing, protective antibodies. These data highlight the importance of FcR-mediated cross-protective immune responses in universal pan-sarbecovirus vaccine designs