Playing Games with Tito:Designing Hybrid Museum Experiences for Critical Play

This article brings together two distinct, but related perspectives on playful museum experiences: Critical play and hybrid design. The article explores the challenges involved in combining these two perspectives, through the design of two hybrid museum experiences that aimed to facilitate critical play with/in the collections of the Museum of Yugoslavia and the highly contested heritage they represent. Based on reflections from the design process as well as feedback from test users, we describe a series of challenges: Challenging the norms of visitor behaviour, challenging the role of the artefact, and challenging the curatorial authority. In conclusion, we outline some possible design strategies to address these challenges

SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immune responses and infection outcomes were evaluated in 2,686 patients with varying immune-suppressive disease states after administration of two Coronavirus Disease 2019 (COVID-19) vaccines. Overall, 255 of 2,204 (12%) patients failed to develop anti-spike antibodies, with an additional 600 of 2,204 (27%) patients generating low levels (<380 AU ml−1). Vaccine failure rates were highest in ANCA-associated vasculitis on rituximab (21/29, 72%), hemodialysis on immunosuppressive therapy (6/30, 20%) and solid organ transplant recipients (20/81, 25% and 141/458, 31%). SARS-CoV-2-specific T cell responses were detected in 513 of 580 (88%) patients, with lower T cell magnitude or proportion in hemodialysis, allogeneic hematopoietic stem cell transplantation and liver transplant recipients (versus healthy controls). Humoral responses against Omicron (BA.1) were reduced, although cross-reactive T cell responses were sustained in all participants for whom these data were available. BNT162b2 was associated with higher antibody but lower cellular responses compared to ChAdOx1 nCoV-19 vaccination. We report 474 SARS-CoV-2 infection episodes, including 48 individuals with hospitalization or death from COVID-19. Decreased magnitude of both the serological and the T cell response was associated with severe COVID-19. Overall, we identified clinical phenotypes that may benefit from targeted COVID-19 therapeutic strategies

Museus Históricos na França: entre a reflexão histórica e a identidade nacional

Historical museums are a current subject in today's academic scenery in France. Two conferences on historical museums which took place by the end of 1996, as well as the reopening of the historical galleries at Versailles Museum early in 1997 show a growing interest in this sort of museum. This article reports the development of museums in France, since the early form of the Museum 01 French monuments, during the French Revolution until the publication, in september 1996, of a Guide to museums and historical collections in France. The A. tries to make clear the changes experienced by these institutions since last century, and to sum up the main arguments around the theme which, alter ali, goes beyond the French and European contexts.1996, de dois colóquios nacionais problematizando os museus desse gênero, bem como a discussão sobre a reabertura das galerias históricas de Versalhes, no início de 1997, demonstram um interesse crescente pela instituição. Este artigo traça um histórico dos museus de história na França, desde sua matriz inicial, delineada no ilfllsée des monllments jrançais durante a Revolução Francesa, até a publicação do Guide des musées et collections d'histoire en France, lançado em setembro de 1996. Através deste percurso, procura-se explicitar as inflexões sofridas pela instituição, desde o século XIX até recentemente, buscando, em especial, situar o conjunto de questionamentos que giram ao redor deste tema que, de resto, ultrapassa o contexto francês e europeu