23 research outputs found
Large-Scale Mitochondrial DNA Analysis of the Domestic Goat Reveals Six Haplogroups with High Diversity
Background.
From the beginning of domestication, the transportation of domestic animals resulted in genetic and demographic processes that explain their present distribution and genetic structure. Thus studying the present genetic diversity helps to better understand the history of domestic species.
Methodology/Principal Findings.
The genetic diversity of domestic goats has been characterized with 2430 individuals from all over the old world, including 946 new individuals from regions poorly studied until now (mainly the Fertile Crescent). These individuals represented 1540 haplotypes for the HVI segment of the mitochondrial DNA (mtDNA) control region. This large-scale study allowed the establishment of a clear nomenclature of the goat maternal haplogroups. Only five of the six previously defined groups of haplotypes were divergent enough to be considered as different haplogroups. Moreover a new mitochondrial group has been localized around the Fertile Crescent. All groups showed very high haplotype diversity. Most of this diversity was distributed among groups and within geographic regions. The weak geographic structure may result from the worldwide distribution of the dominant A haplogroup (more than 90% of the individuals). The large-scale distribution of other haplogroups (except one), may be related to human migration. The recent fragmentation of local goat populations into discrete breeds is not detectable with mitochondrial markers. The estimation of demographic parameters from mismatch analyses showed that all groups had a recent demographic expansion corresponding roughly to the period when domestication took place. But even with a large data set it remains difficult to give relative dates of expansion for different haplogroups because of large confidence intervals.
Conclusions/Significance.
We propose standard criteria for the definition of the different haplogroups based on the result of mismatch analysis and on the use of sequences of reference. Such a method could be also applied for clarifying the nomenclature of mitochondrial haplogroups in other domestic species
Predictive and prognostic value of PET/CT imaging post-chemoradiotherapy and clinical decision-making consequences in locally advanced head & neck squamous cell carcinoma: a retrospective study
Stable Hydrogen Isotope Ratios in Plants: A Review of Current Theory and Some Potential Applications
The role of analogy and metaphor in the framing and legitimization of strategic change
Strategic change initiatives disrupt established categories of stakeholder understanding and typically present a problem of justifying and legitimizing the change to stakeholders in order to gain their buy-in and support. While it has been suggested that the analogical or metaphorical framing of strategic changes is crucial in that it fosters understanding and creates legitimacy for the change, we set out to specify the conditions and uses of analogical and metaphorical framing in effecting support for strategic changes. Specifically, we argue that (a) analogies are more effective in the context of additive changes, whereas metaphors are more apt for substitutive changes, and that (b) relational analogies and metaphors are generally more effective in securing support for strategic changes, as opposed to analogies or metaphors that highlight common attributes. We also argue that the overall effectiveness of analogies and metaphors in the framing of a change is furthermore dependent on (c) the degree to which these frames are culturally familiar to stakeholders and (d) the extent to which they connect with the prior motivations of stakeholders. © The Author(s) 2011