BIOACTIVITY-GUIDED ISOLATION OF MEMORY-ENHANCING COMPOUND FROM CHLOROFORM EXTRACT OF ROOTS OF PLUMBAGO ZEYLANICA LINN.

Aim: The main aim of our study is to isolate the active compound from roots of Plumbago zeylanica Linn. by bioactivity-guided isolation and evaluate its memory-enhancing effect by Morris water maze.Methods: Roots were extracted by successive solvent methods by petroleum ether, chloroform, methanol, butanol, and finally, water. Chloroform extract was selected for isolation, and plumbagin was isolated by hexane and ethyl acetate as solvent system. Plumbagin was evaluated by Morris water test, and brain acetylcholine esterase level was measured.Result: Plumbagin showed a significant decrease of escape latency and increase of time spent in target quadrant by mice in Morris water maze indicating improvement of learning and memory. It also significantly decreases the cholinesterase level in the brain.Conclusion: Learning and memory of mice doubtless may be through embarrassment of brain acetyl cholinesterase activity and through involvement of GABA-benzodiazepine pathway. Further detailed study is required to explore the other possible mechanisms for the management of cognitive disorders

Disseminated primary cutaneous histoplasmosis successfully treated with itraconazole

A 60-year-old immunocompetent lady with disseminated primary cutaneous histoplasmosis is reported. Histology showed a granulomatous skin infiltrate with numerous intracellular PAS positive rounded yeast cells within macrophages. Culture on Sabouraud's dextrose agar yielded a typical cottony white colony characteristic of Histoplasma capsulatum . Treatment with itraconazole showed an excellent response

Influence of variable radius of cutting head trajectory on quality of cutting kerf in the abrasive water jet process for soda-lime glass

The main innovation of this article is the determination of the impact of curvature of a shape cut out in a brittle material using an abrasive water jet (AWJ) process as an important factor of the machined surfaces. The curvature of a shape, resulting from the size of the radius of the cutting head trajectory, is one of the key requirements necessary for ensuring the required surface quality of materials shaped by the abrasive water jet process, but very few studies have been carried out in this regard. An important goal of the experimental studies carried out here and presented in this work was to determine its influence on the quality of the inner and outer surfaces of the cutting kerf. This goal was accomplished by cutting the shape of a spiral in soda–lime glass. For such a shape, the effect of radius of the trajectory of the cutting head on selected parameters of the surface texture of the inner surface of the cutting kerf (IS) and the outer surface of the cutting kerf (OS) was studied. The obtained results of the experimental studies confirmed that the effect of the curvature of the cut shape is important from the point of view of the efficiency of the glass-based brittle material-cutting process using AWJ. Analyses of the surface textures of the areas located in the upper part of the inner and outer surfaces separated by the use of AWJ machining showed that the OS surfaces are characterized by worse technological quality compared with IS surfaces. Differences in the total height of surface irregularities (given by St amplitude parameter), determined on the basis of the obtained results of the measurements of both surfaces of the cutting kerf, were as follows: ΔStr = 50 = 0.6 μm; ΔStr = 35 = 1 μm; ΔStr = 15 = 1.3 μm. The analysis of values measured in areas located in the more sensitive zone of influence of the AWJ outflow proved that the total height of irregularities (St) of the OS was higher. Differences in the total heights of irregularities for inner and outer surfaces of the cutting kerf were as follows: ΔStr = 50 = 2.1 μm; ΔStr = 35 = 3 μm; ΔStr = 15 = 14.1 μm, respectively. The maximum difference in the total heights of irregularities (St), existing between the surfaces considered in a special case (radius 15 mm), was almost 20%, which should be a sufficient condition for planning cutting operations, so as to ensure the workpiece is shaped mainly by internal surfaces

Multi-response optimization of face milling performance considering tool path strategies in machining of Al-2024

It is hypothesized that the orientation of tool maneuvering in the milling process defines the quality of machining. In that respect, here, the influence of different path strategies of the tool in face milling is investigated, and subsequently, the best strategy is identified following systematic optimization. The surface roughness, material removal rate and cutting time are considered as key responses, whereas the cutting speed, feed rate and depth of cut were considered as inputs (quantitative factors) beside the tool path strategy (qualitative factor) for the material Al 2024 with a torus end mill. The experimental plan, i.e., 27 runs were determined by using the Taguchi design approach. In addition, the analysis of variance is conducted to statistically identify the effects of parameters. The optimal values of process parameters have been evaluated based on Taguchi-grey relational analysis, and the reliability of this analysis has been verified with the confirmation test. It was found that the tool path strategy has a significant influence on the end outcomes of face milling. As such, the surface topography respective to different cutter path strategies and the optimal cutting strategy is discussed in detail

Incidence of Anaerobic Bacteria in 118 Patients with Deep-space Head and Neck Infections from the People’s University Hospital of Maxillofacial Surgery, Bhopal, India

susceptibility to antibacterial agents of anaerobic strains in 118 patients with head and neck abscesses (31) and cellulitis (87). Materials and methods: In total, 118 pus specimens from 118 consecutive patients with abscesses (31 cases) and cellulitis (87) of the head and neck were evaluated from 2006 to the end of 2011. The patients were admitted to the University Hospital of Maxillofacial Surgery, Bhopal, India, and comprised 76 men and 42 women: Four children, 103 adults and 11 elderly people. Results: Anaerobic bacteria (174 strains within 18 genera) were found in 88 (74.6%) of the 118 specimens. Anaerobes only were present in 23 (19.5%) specimens, aerobic/facultative bacteria only in 20 (16.9%) and mixed aerobic/anaerobic flora in 65 (55.1%). No growth was detected in 10 (8.5%) specimens. Two or more anaerobes per specimen were found in 56 (63.6%) of the specimens yielding anaerobes. The incidence of isolation of anaerobes from patients with identified odontogenic sources of infection was 82.2% (60 of 73 cases) and that in patients with other sources of infection was 71.4% (15 of 21, p > 0.20).  Conclusion: The start of empirical treatment could influence the frequency or rate of isolation of Fusobacterium species. The involvement of the Bacteroides fragilis group in some head and neck infections should be considered.&nbsp

Parametric optimization for improving the machining process of Cu/Mo-SiCP composites produced by powder metallurgy

The features of composite materials such as production flexibility, lightness, and excellent strength put them in the class of materials that attract attention in various critical areas, i.e., aerospace, defense, automotive, and shipbuilding. However, the machining of composite materials displays challenges due to the difficulty in obtaining structural integrity. In this study, Cu/Mo-SiCP composite materials were produced by powder metallurgy with varied reinforcement ratios and then their machinability was investigated. In machinability experiments, the process parameters were selected as cutting speed (vC), feed rate (f), depth of cut (aP), and reinforcement ratio (RR). Two levels of these parameters were taken as per the Taguchi’s L8 orthogonal array, and response surface methodology (RSM) is employed for parametric optimization. As a result, the outcomes demonstrated that RR = 5%, f = 0.25 mm/rev, aP = 0.25 mm, vC = 200 m/min for surface roughness, RR = 0%, f = 0.25 mm/rev and aP = 0.25 mm and vC = 200 m/min for flank wear and RR = 0%, f = 0.25 mm/rev, aP = 0.25 mm, vC = 150 m/min for cutting temperature for cutting temperature and flank wear should be selected for the desired results. In addition, ANOVA results indicate that reinforcement ratio is the dominant factor on all response parameters. Microscope images showed that the prominent failure modes on the cutting tool are flank wear, built up edge, and crater wear depending on reinforcement ratio

Analysis of Computer Network Security Storage System Based on Cloud Computing Environment

A fundamental component of cloud computers from a business perspective is that users are allowed to use any desire and pay with a product that desire. Its cloud services were accessible anytime and anywhere consumers needed them. As a result, consumers are free to purchase whatever IT services they want, and they don't have to worry about how easy things can be managed. The remote server is used in a new information storage computing architecture that is considered an Internet generation. Ensuring security, material at resource providers' sites is a challenge that must be addressed in cloud technology. Thus, rather than reliance on a single provider for knowledge storing, this research implies developing construction for protection of knowledge stockpiling with a variation of operations, in which knowledge is scrambled and divided into numerous cipher frames and distributed across a large number of provider places. This support was applied to provide greater security, scalability, or reliability that was suggested according to the new structure. This paper, presented an encoded model for the cloud environment to improve security. The proposed model comprises the parity metadata for the database management provision to the provider. In the developed encoder chunks parity is not stored within the single resources with the provision of the available information chunks. The constructed security architecture in the RAID layer increases the dependability of the data with the deployment of the RAID 10 deployment. The developed RAID-based encoder chunks exhibit improved efficiency for the higher uptime at a minimal cost

On the role of different Skyrme forces and surface corrections in exotic cluster-decay

We present cluster decay studies of $^{56}$Ni$^*$ formed in heavy-ion collisions using different Skyrme forces. Our study reveals that different Skyrme forces do not alter the transfer structure of fractional yields significantly. The cluster decay half-lives of different clusters lies within \pm 10% for PCM and \pm 15% for UFM.Comment: 13 pages,6 figures and 1 table; in press Pramana Journal of Physics (2010