Etude des effets du chlorure d'aluminium sur la structure histologique du foie et de la rate des rates gestantes et leurs fœtus

Histological study of organs reflects the General State of animals, including, if they are subject to treatment. The purpose of our study is to elucidate the effect of the administration of different doses (50, 100 and 200 mg/Kg/day) of aluminum chloride during the days 9-13 of gestation on the histological structure of the liver and the spleen of pregnant rats and their offspring. In pregnant rats, AlCl3 leads, at the level of the liver, to a very important development of the connective tissue of the centrilobular vein, with inflammatory foci and hepatocyte injury. While at the level of the spleen, there is a development of the white pulp against the red pulp with an abundance of conjunctive fibres and dilation of the lining of arterioles, which reflects a failure of the circulatory system. The fetuses of rats treated by AlCl3, show no change in the histological structure of the spleen. The AlCl3 action is more marked than mothers in their fetuses. This certifies that the placenta forms a more or less selective barrier to some constituents, and that spleen in fetuses temporarily offset the effects of AlCl3L’étude histologique des organes reflète l’état général des animaux, notamment, si ceux-ci, sont sujets à un traitement. Le but de notre étude est d’élucider l’effet de l’administration de différentes doses (50, 100 et 200 mg d’AlCl3/Kg/j de chlorure d’aluminium durant les jours 9-13 de gestation sur la structure histologique du foie et de la rate des rates gestantes et de leur progéniture. Chez les rates gestantes, l’AlCl3 entraîne, au niveau du foie, un développement très important du tissu conjonctif de la veine centrolobulaire, avec apparition de foyers inflammatoires et lésion d’hépatocytes. Alors qu’au niveau de la rate, on note un développement de la pulpe blanche aux dépens de la pulpe rouge avec une abondance de fibres conjonctives et une dilatation de la paroi des artérioles, ce qui témoigne d’une défaillance du système circulatoire. Les fœtus des rates traitées par l’AlCl3, ne montrent aucune modification de la structure histologique de la rate. L’action d’AlCl3 est plus marquée chez les mères que chez leurs fœtus. Ceci atteste que le placenta forme une barrière plus ou moins sélective envers certains constituants, et que la rate des fœtus contrebalance momentanément les effets d’AlCl3

EFFETS DU CHLORURE D'ALUMINIUM SUR LA STRUCTURE HISTOLOGIQUE DES POUMONS, REINS ET INTESTIN DES RATS FEMELLES GESTANTES ET LEURS FŒTUS

The aim of our study is to elucidate the effects of the administration of different doses of aluminium chloride during 9-13 gestation day on organs histology of pregnant rats and their offspring. We have noted that in pregnant rats, there is a change on the histological structure of intestine especially on enterocytes, nuclei and basal lamina. In kidney, we have observed a lesion in proximal and distal tubes. In lungs, AlCl3 may decrease the alveolar diameter, an inflammation with necrosis of pneumocytes notably with the dose of 200 mg of AlCl3 /kg/day. In fetuses, AlCl3 may cause a detachment between the intestinal epithelium and the underlying conjonctif and a necrosis of renal and pulmonary cells. AlCl3 has an effect more marked in mother than their fetuses. This indicates that the placenta is a selective barrier towards some components.Le but de notre étude est d’élucider l’effet de l’administration de différentes doses de chlorure d’aluminium durant les jours 9-13 de gestation sur la structure histologique des poumons, reins et intestin des rates gestantes et de leur progéniture. Chez les rates gestantes, le traitement par AlCl3 entraîne au niveau de l’intestin, une modification des structures des entérocytes, noyaux et lames basales. Au niveau rénal, on observe des lésions des tubules proximaux et distaux. Au niveau des poumons, on constate une diminution du diamètre alvéolaire, une inflammation avec une nécrose des pneumocytes notamment pour la dose de 200 mg/kg/j. Chez les fœtus émanant de rates traitées par le chlorure d’aluminium, on observe un décollement entre l’épithélium intestinal et le conjonctif sous-jacent et une nécrose des cellules rénales et pulmonaires. L’action du chlorure d’aluminium est plus marquée chez les mères que chez leurs fœtus. Ceci atteste que le placenta forme une barrière plus ou moins sélective vis-à-vis de certains constituants vers les fœtus

Assessing the life quality in a Moroccan population of diabetics by the General Quality of Life Questionnaire SF36

Background: The quality of life assessment reflects the impact of chronic diseases on patients. The objective of our study is to assess the life quality of diabetic patients and to determine the factors that affect it.Methods: A cross-sectional study was conducted in 2019 in the Hygiene Service of the Sidi-Othmane district (Casablanca) in 526 diabetic patients. Quality of life was estimated using the SF-36 questionnaire to determine factors that affect mental or physical health. We used Pearson's correlation test for continuous variables and ANOVA for discontinuous variables.Results: Our patients have an average of life quality considering PCS and MCS respectively (38.47 ± 9.28; 41.15 ± 10.55). Association analyses showed on the one hand associations between the PCS and the gender (p = 0.0001), professional activity (p = 0.0001), marital status (p = 0.0001) and with chronic complications (p = 0.0001). On the other hand, between physical activity and PCS (p = 0.0001) and with MCS (p = 0.0001), between the level of instruction and the PCS and MCS dimensions respectively (p = 0.0001; p = 0.011) between acute complications and PCS and MCS dimensions respectively (p = 0.0001; p = 0.001). The correlation study showed inverse correlations between PCS and age (p = 0.0001), the diabetes duration (p = 0.0001), HbA1c (p = 0.037), and BMI (p = 0.008), and between MCS, and BMI (p = 0.0001).Conclusion: The presence of one of these factors (female, advanced age, high diabetes duration, complications, and unbalanced diabetes, low level of education, physical inactivity, and professional inactivity) leads to poor life quality.Keywords: Diabetes; Life quality; Physical health; Mental healt

Vitamine D3 et cellule B du pancreas endocrine

SIGLECNRS T 59343 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

Etude des effets du chlorure d'aluminium sur la structure histologique du foie et de la rate des rates gestantes et leurs fœtus

Histological study of organs reflects the General State of animals, including, if they are subject to treatment. The purpose of our study is to elucidate the effect of the administration of different doses (50, 100 and 200 mg/Kg/day) of aluminum chloride during the days 9-13 of gestation on the histological structure of the liver and the spleen of pregnant rats and their offspring. In pregnant rats, AlCl3 leads, at the level of the liver, to a very important development of the connective tissue of the centrilobular vein, with inflammatory foci and hepatocyte injury. While at the level of the spleen, there is a development of the white pulp against the red pulp with an abundance of conjunctive fibres and dilation of the lining of arterioles, which reflects a failure of the circulatory system. The fetuses of rats treated by AlCl3, show no change in the histological structure of the spleen. The AlCl3 action is more marked than mothers in their fetuses. This certifies that the placenta forms a more or less selective barrier to some constituents, and that spleen in fetuses temporarily offset the effects of AlCl3L’étude histologique des organes reflète l’état général des animaux, notamment, si ceux-ci, sont sujets à un traitement. Le but de notre étude est d’élucider l’effet de l’administration de différentes doses (50, 100 et 200 mg d’AlCl3/Kg/j de chlorure d’aluminium durant les jours 9-13 de gestation sur la structure histologique du foie et de la rate des rates gestantes et de leur progéniture. Chez les rates gestantes, l’AlCl3 entraîne, au niveau du foie, un développement très important du tissu conjonctif de la veine centrolobulaire, avec apparition de foyers inflammatoires et lésion d’hépatocytes. Alors qu’au niveau de la rate, on note un développement de la pulpe blanche aux dépens de la pulpe rouge avec une abondance de fibres conjonctives et une dilatation de la paroi des artérioles, ce qui témoigne d’une défaillance du système circulatoire. Les fœtus des rates traitées par l’AlCl3, ne montrent aucune modification de la structure histologique de la rate. L’action d’AlCl3 est plus marquée chez les mères que chez leurs fœtus. Ceci atteste que le placenta forme une barrière plus ou moins sélective envers certains constituants, et que la rate des fœtus contrebalance momentanément les effets d’AlCl3

Cancer du sein au Maroc: profil phénotypique des tumeurs

Le cancer du sein est le plus fréquent chez la femme et figure parmi les principales causes de mortalité liée au cancer. La curabilité de ce type tumoral est en augmentation, grâce aux programmes de dépistage et aux progrès thérapeutiques, qui ont certes augmenté la survie des patients. Mais des défis restent à relever en rapport avec l’instabilité phénotypique des cellules cancéreuses. L’objectif de ce travail est d’étudier le profil phénotypique du cancer du sein chez les patients pris en charge au Centre Mohammed VI pour le traitement des Cancer, durant les années 2013-2014. Il s’agit d’une étude transversale sur deux années, incluant les cas du cancer du sein pris en charge au Centre. Le recueil des données était fait à partir des dossiers des patients et analysés par le logiciel Epi Info. 1277 patients ont été pris en charge au sein de notre centre. 99,5% des cas de sexe féminin, l’âge moyen était 50,20 ± 11,34 ans. Le type histologique le plus fréquent était le carcinome canalaire infiltrant (80,7% des cas). Le stade diagnostic était précoce (56,9%). Le phénotype moléculaire le plus fréquent était le luminal A (41,4% des cas). Le luminal B, le HER2 et Les triples négatifs étaient dans respectivement 10,4%, 6,3%, 11,2% des cas. L’étude du phénotype tumorale des patients atteints du cancer du sein permet l’orientation du clinicien dans le choix du traitement, et des décideurs dans la planification de programmes de lutte contre cette pathologie.The Pan African Medical Journal 2016;2

Molecular genetic analysis of the m.A3243G mutation of the tRNALeu (UUR) gene in a population of Moroccan deaf diabetics

Background: The mitochondrial DNA (mtDNA) m.A3243G mutation of the tRNALeu (UUR) gene presents clinically heterogeneous phenotypes and is often responsible for diabetes, with or without deafness syndrome. The aim of this study was to search for this pathogenic mutation in 3 diabetics with bilateral deafness and a family history of diabetes.Methods: mtDNA was extracted from the patients' whole blood. After PCR amplification, the DNA was sequenced and analyzed.Results: The sequencing results showed the absence of the most common mtDNA mutation m.A3243G in diabetic families with individuals who suffer from hearing loss.Conclusions: The m.A3243G mutation in the mitochondrial tRNALeu (UUR) Leu gene was not found to be a common cause of type 2 diabetes and deafness. These results suggest that there may be genetic causes for this phenotype.Keywords: Diabetes; Deafness; M.A3243G Mutation; Mitochondrial DNA

Study of Anthropometric and Biological parameters in a Diabetic population of Casablanca, Morocco

Diabetes mellitus is a public health problem. Our objective is to study the epidemiological profile of diabetes in a population of Casablanca in the Sidi-Othmane district. A retrospective study which took place from January 2007 to May 2018. It is a collection of anthropometric parameters and certain biological parameters. Statistical analysis was studied using the Pearson test and the Student test. The p value <0.05 is statistically significant. A total of 1479 subjects were collected, mainly women (78.7%), with an average age of 56 ± 11 years. The average BMI is 28.34 ± 5.11 kg / m². 40.45% of patients are overweight and 31% obese. The average fasting blood glucose = 1.82 ± 0.73 g / l while the average postprandial glycemia = 2.55 ± 1.16 g / l. Mean HbA1c = 7.6 ± 1.4% confirming the poor glycemic control observed. A significant correlation was observed between glycated hemoglobin (HbA1c) and fasting blood glucose (r² = 0.58, p = 0.001). Hypertension was found in 43.7% of the diabetics. The lipid balance of our patients is characterized by an average cholesterolemia of 2 ± 0.41g / l, HDLc = 0.5 ± 0.21g / l, LDLc: 1.73 ± 0.43g / l and a triglyceride level = 1.37 ± 0.73 g / l. Of the 21.4% of diabetics who died, 58% were women. The most serious causes of death are linked to hypertension. The study shows the existence of factors predisposing to fatal complications that must be worked on to at least reduce the costly complications to manage. The use of HbA1c as a means of controlling the glycemic balance of individuals is a practical and motivating tool for the primary prevention of degenerative complications of diabetes

Breast Cancer in Men: Characteristics Epidemiological, Clinicopathological and Therapeutic

Abstract Background: Breast cancer is the leading malignancy in women, but it is relatively rare in men, accounting for 1% of all breast cancers. In Morocco, its incidence is 0.8/ 100,000 in men. This condition epidemiology, therapeutic and prognostic remains unknown given the scarcity of reported series. The objective of this work is to identify the epidemiological, clinical, pathological and therapeutic of this cancer in men. Results: Six patients were diagnosed with breast cancer with a ratio of 6/1277 cases. The mean age of patients was 63.3 ± 9.7 ans; the most common histological type was invasive ductal carcinoma (83.3%). The grade 2 SBR has a majority (66.7%), while that of SBR 3 is less represented (33.3%). A positive estrogen receptor (66.7% of cases) and progesterone (50.0% of cases) was noted. The HER2 receptor is overexpressed in 25% of cases. The treatment was essentially surgical (83.3%). Additional treatment included adjuvant chemotherapy (50.0%), radiotherapy (50.0%) and hormonal therapy (16.7%) was administered. Discussion/Conclusion: Breast cancer in men is rare and appears to have a very close clinical, histological characteristics and prognosis to those of elderly women. The diagnosis is usually late and tumors are treated in advanced stages. An improved prognosis requires better awareness for early detection