122 research outputs found
Comparison between endoscopic and surgical treatment of screen-detected versus non-screen-detected colorectal cancers
Theoretical Aspects of Dark Matter Detection
Direct and indirect dark matter detection relies on the scattering of the dark matter candidate on nucleons or nuclei. Here, attention is focused on dark matter candidates (neutralinos) predicted in the minimal supersymmetric standard model and its constrained version with universal input soft supersymmetry-breaking masses. Current expectations for elastic scattering cross sections for neutralinos on protons are discussed with particular attention to satisfying all current accelerator constraints as well as insuring a sufficient cosmological relic density to account for the dark matter in the Universe
Activated Magnetospheres of Magnetars
Like the solar corona, the external magnetic field of magnetars is twisted by
surface motions of the star. The twist energy is dissipated over time. We
discuss the theory of this activity and its observational status. (1) Theory
predicts that the magnetosphere tends to untwist in a peculiar way: a bundle of
electric currents (the "j-bundle") is formed with a sharp boundary, which
shrinks toward the magnetic dipole axis. Recent observations of shrinking hot
spots on magnetars are consistent with this behavior. (2) Continual discharge
fills the j-bundle with electron-positron plasma, maintaining a nonthermal
corona around the neutron star. The corona outside a few stellar radii strongly
interacts with the stellar radiation and forms a "radiatively locked" outflow
with a high e+- multiplicity. The locked plasma annihilates near the apexes of
the closed magnetic field lines. (3) New radiative-transfer simulations suggest
a simple mechanism that shapes the observed X-ray spectrum from 0.1 keV to 1
MeV: part of the thermal X-rays emitted by the neutron star are reflected from
the outer corona and then upscattered by the inner relativistic outflow in the
j-bundle, producing a beam of hard X-rays.Comment: 23 pages, 7 figures; review chapter in the proceedings of ICREA
Workshop on the High-Energy Emission from Pulsars and Their Systems, Sant
Cugat, Spain, April 201
Quantitative RT-PCR profiling of the Rabbit Immune Response: Assessment of Acute Shigella flexneri Infection
Quantitative reverse transcription PCR analysis is an important tool to monitor changes in gene expression in animal models. The rabbit is a widely accepted and commonly used animal model in the study of human diseases and infections by viral, fungal, bacterial and protozoan pathogens. Only a limited number of rabbit genes have, however, been analyzed by this method as the rabbit genome sequence remains unfinished. Recently, increasing coverage of the genome has permitted the prediction of a growing number of genes that are relevant in the context of the immune response. We hereby report the design of twenty-four quantitative PCR primer pairs covering common cytokines, chemoattractants, antimicrobials and enzymes for a rapid, sensitive and quantitative analysis of the rabbit immune response. Importantly, all primer pairs were designed to be used under identical experimental conditions, thereby enabling the simultaneous analysis of all genes in a high-throughput format. This tool was used to analyze the rabbit innate immune response to infection with the human gastrointestinal pathogen Shigella flexneri. Beyond the known inflammatory mediators, we identified IL-22, IL-17A and IL-17F as highly upregulated cytokines and as first responders to infection during the innate phase of the host immune response. This set of qPCR primers also provides a convenient tool for monitoring the rabbit immune response during infection with other pathogens and other inflammatory conditions
Skeleton of an unusual cat-sized marsupial relative (Metatheria: Marsupialiformes) from the middle Eocene (Lutetian: 44-43 million years ago) of Turkey
We describe a near-complete, three-dimensionally preserved skeleton of a metatherian (relative of modern marsupials) from the middle Eocene (Lutetian: 44–43 million years ago) Lülük member of the Uzunçarşıdere Formation, central Turkey. With an estimated body mass of 3–4 kg, about the size of a domestic cat (Felis catus) or spotted quoll (Dasyurus maculatus), it is an order of magnitude larger than the largest fossil metatherians previously known from the Cenozoic of the northern hemisphere. This new taxon is characterised by large, broad third premolars that probably represent adaptations for hard object feeding (durophagy), and its craniodental morphology suggests the capacity to generate high bite forces. Qualitative and quantitative functional analyses of its postcranial skeleton indicate that it was probably scansorial and relatively agile, perhaps broadly similar in locomotor mode to the spotted quoll, but with a greater capacity for climbing and grasping. Bayesian phylogenetic analysis of a total evidence dataset comprising 259 morphological characters and 9kb of DNA sequence data from five nuclear protein-coding genes, using both undated and “tip-and-node dating” approaches, place the new taxon outside the marsupial crown-clade, but within the clade Marsupialiformes. It demonstrates that at least one metatherian lineage evolved to occupy the small-medium, meso- or hypo-carnivore niche in the northern hemisphere during the early Cenozoic, at a time when there were numerous eutherians (placentals and their fossil relatives) filling similar niches. However, the known mammal fauna from Uzunçarşıdere Formation appears highly endemic, and geological evidence suggests that this region of Turkey was an island for at least part of the early Cenozoic, and so the new taxon may have evolved in isolation from potential eutherian competitors. Nevertheless, the new taxon reveals previously unsuspected ecomorphological disparity among northern hemisphere metatherians during the first half of the Cenozoic
Validation of the "Six Step Spot Test" for gait among patients with multiple sclerosis in Brazil
Patterns of arboreal and terrestrial space use by non-volant small mammals in an Araucaria forest of southern Brazil
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