EVALUATION OF WOUND HEALING POTENTIAL OF CRUDE EXTRACTS OF ZYZIPHUS OENOLPIA L. MILL (INDIAN JUJUBA) IN WISTAR RATS.

Zyziphus oenoplia is a perennial shrub used in traditional medicine for treating hyper acidity, Ascaris infection, stomachalgia and healing of wounds. The objective of this study was to investigate the root extracts of this plant, to evaluate their wound healing potential in rats. Excision, Incision and Dead space wound modals were used to evaluate the wound healing activity of the extracts on wister rats. In each modal, animals were divided into six groups of six animals. Each model, group I & II served as control and reference standard. In wound models, group III, IV, V and VI animals were treated with plant root extracts (300 and 400mg/kg/day) for 18 days and 10days respectively. The vehicles effect  on the rate of wound healing were assessed by the wound closure rate, epithelialisation period, tensile strength, granulation tissue weight, hydroxyproline content and histopathology of granulation tissue. The ethanol extract of plant root promoted wound healing activity significantly in all the wound modals. High rate wound contraction (P<0.001), decrease in the epithelialisation period (14.67±0.33), high skin breaking strength (501.53±2.18g), significant increase in granulation tissue weight (P<0.001) and hydroxyproline (P<0.001) content were observed in ethanol root extract. Histological studies of the granulation tissues of the ethanolic extract treated group showed the lesser number of inflammatory cells, and increase collagen formation than the control and also compared with other groups. Phytoconstituents like flavanoids, alkaloids, steroids, triterpenoids, saponins etc were also confirmed by phytochemical test. The data obtained in this investigation indicated that the ethanolic root extract possesses better wound healing activity and it can treat different types of wounds in human being too

EVALUATION OF WOUND HEALING POTENTIAL OF CRUDE EXTRACTS OF ZYZIPHUS OENOLPIA L. MILL (INDIAN JUJUBA) IN WISTAR RATS.

Zyziphus oenoplia is a perennial shrub used in traditional medicine for treating hyper acidity, Ascaris infection, stomachalgia and healing of wounds. The objective of this study was to investigate the root extracts of this plant, to evaluate their wound healing potential in rats. Excision, Incision and Dead space wound modals were used to evaluate the wound healing activity of the extracts on wister rats. In each modal, animals were divided into six groups of six animals. Each model, group I & II served as control and reference standard. In wound models, group III, IV, V and VI animals were treated with plant root extracts (300 and 400mg/kg/day) for 18 days and 10days respectively. The vehicles effect  on the rate of wound healing were assessed by the wound closure rate, epithelialisation period, tensile strength, granulation tissue weight, hydroxyproline content and histopathology of granulation tissue. The ethanol extract of plant root promoted wound healing activity significantly in all the wound modals. High rate wound contraction (P<0.001), decrease in the epithelialisation period (14.67±0.33), high skin breaking strength (501.53±2.18g), significant increase in granulation tissue weight (P<0.001) and hydroxyproline (P<0.001) content were observed in ethanol root extract. Histological studies of the granulation tissues of the ethanolic extract treated group showed the lesser number of inflammatory cells, and increase collagen formation than the control and also compared with other groups. Phytoconstituents like flavanoids, alkaloids, steroids, triterpenoids, saponins etc were also confirmed by phytochemical test. The data obtained in this investigation indicated that the ethanolic root extract possesses better wound healing activity and it can treat different types of wounds in human being too

HYPOGLYCEMIC ACTIVITY OF A NOVEL POLYHERBAL FORMULATION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS: A THERAPEUTIC STUDY

Objective: The concept of the synergistic effect of poly-herbalism was as old as medicine history. Present novel polyherbal formulation (PHF) composed of five different herbs. The present investigation aimed to evaluate the synergistic therapeutic hypoglycemic potential of PHF against streptozotocin (STZ) (60 mg/kg b.w, ip)-induced diabetic rats. Methods: For this therapeutic study, the dose was framed orally once a day to the test objects after STZ dosing at 500 mg/kg/5 ml dosage levels for 21 days. The transformation of body weight and blood glucose level was examined, and the histopathological changes of beta cells of the pancreas, cellular architectures of liver and kidney were also perceived after scarification of the objects. Results: The outcomes were compared to that of glibenclamide (5 mg/kg) treated group. Declines of body weight and blood glucose levels were perceived in STZ-induced diabetic animals very significantly (p<0.01 or p<0.05). However, these diabetic changes were significantly (p<0.01 or p<0.05) decreased in PHF-dosing groups revealed more encouraging effects compared to that of glibenclamide. In the other hand, various liver function and enzymes test (creatinine, urea, total bilirubin, total albumin, alkaline phosphatase, gamma-glutamyl transferase, aspartate transaminases, and alanine transaminases) and lipid profile (total cholesterol, triglycerides, high-density lipoprotein cholesterol, total protein, low-density lipoprotein [LDL], and very LDL) studies strongly indicate the potential action of this novel formulation. Conclusions: It is deliberated that PHF has the favorable effect to normalize the blood glucose levels, and also rejuvenation and reproduction of beta cells lead a better futuristic ant diabetic therapy for diabetic management

A Comprehensive Ethno-Phyto-Pharmacological Review on Novel Indian Medicinal Plants Used In Polyherbal Formulations

Almost 15% out of the 20,000 medicinal plants in Indian sub continent has a tremendous potential and advantage in the emerging field of herbal medicines. Medicinal plants are the main sources of chemical substances with potential therapeutic effects. A lot of compounds were characterized from plants which are now using in the treatment of many diseases. Since ancient times, plants have been an exemplary source of medicine. Ayurveda and other Indian literature mentioned the use of plants in treatment of various human ailments. Medical plants play an important role in the management of different clinical problems especially in developing countries where resources are meager The present paper reviews the literature on recent ethno medicinal uses with pharmacological screeing of every plant part of different five medicinal plants, i.e Cassia Auriculata Linn, Cinnamomum tamala, Ficus benghalensis, Trichosynthes dioica and Mangifera indica and their phytochemical properties used for the treatment of various ailments in human civilization as well as used in folk medicine as a remedy. The name and parts of the plant studied, the spectrum of activity, and methods used are discussed in this review paper

A Comprehensive Ethno-Phyto-Pharmacological Review on Novel Indian Medicinal Plants Used In Polyherbal Formulations

Almost 15% out of the 20,000 medicinal plants in Indian sub continent has a tremendous potential and advantage in the emerging field of herbal medicines. Medicinal plants are the main sources of chemical substances with potential therapeutic effects. A lot of compounds were characterized from plants which are now using in the treatment of many diseases. Since ancient times, plants have been an exemplary source of medicine. Ayurveda and other Indian literature mentioned the use of plants in treatment of various human ailments. Medical plants play an important role in the management of different clinical problems especially in developing countries where resources are meager The present paper reviews the literature on recent ethno medicinal uses with pharmacological screeing of every plant part of different five medicinal plants, i.e Cassia Auriculata Linn, Cinnamomum tamala, Ficus benghalensis, Trichosynthes dioica and Mangifera indica and their phytochemical properties used for the treatment of various ailments in human civilization as well as used in folk medicine as a remedy. The name and parts of the plant studied, the spectrum of activity, and methods used are discussed in this review paper

Ethno-medicinal, Phytochemical and Pharmacological review of an amazing medicinal herb Peperomia pellucida (L.) HBK

ABSTRACT Peperomia pellucida (L.) HBK (Fam. Piperaceae) has been used as a (Rasayan) drug in the Ayurvedic system of medicines. Peperomia pellucida is reported to posse antipyretic, analgesic, anti-inflammatory, antimicrobial, refrigerant and CNS activity. Traditionally it is used in the treatment of headache, fever, eczema, abdominal pains, and convulsions. In traditional Ayurvedic system of medicine in India Peperomia pellucida is used as Rasa, Guna and Virya. Phytochemical screening of this plant has shown the presence of flavonoids, tannins, alkaloids, steriod and triterpenoid. Isolation of antifungal and anticancer constituents from this plant was also reported newly. The present study is based on the work done till date regarding the phytoconstituents and pharmacological activity of Peperomia pellucida

Antifungal Activity of Weed Extracts on Candida Albicans: An In-vitro Study

The genus Candida is caused morbidity and mortality in human beings. The virulence factors of the Candida albicans have the great role in the pseudohyphae formation by attached with epithelial cells and endothelial cells. The aim of the study was to evaluate the antifungal activity of weed extracts used in traditional herbal medicine. The weeds were selected on the basis of their reported ethnobotanical uses. Water and alcoholic weed extracts were screened in vitro for their antifungal activity against fungus C. albicans. 50μl concentration of minimal Inhibitory Concentration (MIC) of Mimosa pudica extract in alcohol and 70μl concentration of MIC of Oxalis corniculata extract shows in alcohol. We conclude from this that these extracts exhibit amazing fungicidal properties that support their traditional uses. The presence of phytochemicals in the extracts including, tannins, alkaloids, steroids, glycosides, triterpenoids, flavonoids, phenolic compounds and organic acids like, Malic acid, tartaric acid and citric acid may be responsible for these activities. The acetone extracts of plant are more efficient as compared to the water extract.