437 research outputs found
Kinder als Mitbetroffene von häuslicher Gewalt : die Vernetzung der betroffenen Kinder mit der Opferhilfe im Kanton Bern
Dans le présent travail, on se pose les questions de savoir si, dans le canton de Berne, il existe un besoin d'agir et d'intégrer les enfants touchés par la violence conjugale (on parle ici des actes de violence entre les parents) à l'aide aux victimes d'infractions.
Le travail se concentre sur des enfants de moins de 12 ans, dont les parents, conscients de leur violence, se sont annoncés eux-mêmes à un centre de consultation. Les enfants n'ont aucune offre de soutien (par ex : protection de droit civil de l'enfant). Ces parents sont donc les personnes de contact de référence capables de défendre les intérêts des enfants, ce sont eux qui peuvent mettre les enfants en contact avec les systèmes de soutien appropriés. Généralement, à cet âge, les enfants ne peuvent pas encore chercher de l'aide eux-mêmes. Les centres de consultation sont donc les seules institutions d'état qui, dans de tels cas, offrent des aides de soutien, qui connaissent la situation des enfants, et qui par l'intermédiaire des parents, ont un contact indirect avec les enfants.
In der vorliegenden Arbeit wird den Fragen nachgegangen, ob im Kanton Bern ein Handlungsbedarf besteht, Kinder, die von häuslicher Gewalt (hier verstanden als Gewalthandlungen zwischen den Eltern) betroffen sind, mit der Opferhilfe zu vernetzen?
Der Fokus der Arbeit liegt auf Kindern unter 12 Jahren, deren gewaltbetroffene Elternteile sich aufgrund des eigenen Gewalterlebens selbständig bei einer Opferhilfeberatungsstelle gemeldet haben. Ihre Kinder sind mit keinem Unterstützungsangebot vernetzt (z.B. zivilrechtlicher Kindesschutz). Diese Elternteile sind die zentralen Ansprechpersonen für die Belange der Kinder, sie können die Kinder mit geeigneten Unterstützungssystemen vernetzen. Die Kinder selbst können sich in diesem Alter in der Regel noch nicht selbständig Hilfe organisieren. Die Opferhilfeberatungsstellen sind damit die einzigen staatlichen Institutionen, die in solchen Fällen Unterstützungsleistungen bieten, von der Situation der Kinder Kenntnis haben und über die gewaltbetroffenen Eltern auch indirekten Kontakt zu den Kindern haben
The Post-Pericenter Evolution of the Galactic Center Source G2
In early 2014 the fast-moving near-infrared source G2 reached its closest
approach to the supermassive black hole Sgr A* in the Galactic Center. We
report on the evolution of the ionized gaseous component and the dusty
component of G2 immediately after this event, revealed by new observations
obtained in 2015 and 2016 with the SINFONI integral field spectrograph and the
NACO imager at the ESO VLT. The spatially resolved dynamics of the Br
line emission can be accounted for by the ballistic motion and tidal shearing
of a test-particle cloud that has followed a highly eccentric Keplerian orbit
around the black hole for the last 12 years. The non-detection of a drag force
or any strong hydrodynamic interaction with the hot gas in the inner accretion
zone limits the ambient density to less than a few 10 cm at the
distance of closest approach (1500 ), assuming G2 is a spherical cloud
moving through a stationary and homogeneous atmosphere. The dust continuum
emission is unresolved in L'-band, but stays consistent with the location of
the Br emission. The total luminosity of the Br and L' emission
has remained constant to within the measurement uncertainty. The nature and
origin of G2 are likely related to that of the precursor source G1, since their
orbital evolution is similar, though not identical. Both object are also likely
related to a trailing tail structure, which is continuously connected to G2
over a large range in position and radial velocity.Comment: 17 pages, 12 figures; accepted for publication in Ap
Genome-Wide Analysis of the Yeast Transcriptome Upon Heat and Cold Shock
DNA arrays were used to measure changes in transcript levels as yeast cells responded to temperature shocks. The number of genes upregulated by temperature shifts from
30 ℃ to 37℃ or 45℃ was correlated with the severity of the stress. Pre-adaptation
of cells, by growth at 37 ℃ previous to the 45℃ shift, caused a decrease in the
number of genes related to this response. Heat shock also caused downregulation of a
set of genes related to metabolism, cell growth and division, transcription, ribosomal
proteins, protein synthesis and destination. Probably all of these responses combine
to slow down cell growth and division during heat shock, thus saving energy for
cell rescue. The presence of putative binding sites for Xbp1p in the promoters of
these genes suggests a hypothetical role for this transcriptional repressor, although
other mechanisms may be considered. The response to cold shock (4℃) affected a
small number of genes, but the vast majority of those genes induced by exposure to
4 ℃ were also induced during heat shock; these genes share in their promoters cis-regulatory
elements previously related to other stress responses
An integrated gene annotation and transcriptional profiling approach towards the full gene content of the Drosophila genome
BACKGROUND: While the genome sequences for a variety of organisms are now available, the precise number of the genes encoded is still a matter of debate. For the human genome several stringent annotation approaches have resulted in the same number of potential genes, but a careful comparison revealed only limited overlap. This indicates that only the combination of different computational prediction methods and experimental evaluation of such in silico data will provide more complete genome annotations. In order to get a more complete gene content of the Drosophila melanogaster genome, we based our new D. melanogaster whole-transcriptome microarray, the Heidelberg FlyArray, on the combination of the Berkeley Drosophila Genome Project (BDGP) annotation and a novel ab initio gene prediction of lower stringency using the Fgenesh software. RESULTS: Here we provide evidence for the transcription of approximately 2,600 additional genes predicted by Fgenesh. Validation of the developmental profiling data by RT-PCR and in situ hybridization indicates a lower limit of 2,000 novel annotations, thus substantially raising the number of genes that make a fly. CONCLUSIONS: The successful design and application of this novel Drosophila microarray on the basis of our integrated in silico/wet biology approach confirms our expectation that in silico approaches alone will always tend to be incomplete. The identification of at least 2,000 novel genes highlights the importance of gathering experimental evidence to discover all genes within a genome. Moreover, as such an approach is independent of homology criteria, it will allow the discovery of novel genes unrelated to known protein families or those that have not been strictly conserved between species
A Detection of Sgr A* in the far infrared
We report the first detection of the Galactic Centre massive black hole,
Sgr~A*, in the far infrared. Our measurements were obtained with PACS on board
the \emph{Herschel} satellite at and .
While the warm dust in the Galactic Centre is too bright to allow for a direct
detection of Sgr~A*, we measure a significant and simultaneous variation of its
flux of and during one observation. The significance level of
the band variability is and the corresponding
band variability is significant at . We find
no example of an equally significant false positive detection. Conservatively
assuming a variability of in the FIR, we can provide upper limits to the
flux. Comparing the latter with theoretical models we find that 1D RIAF models
have difficulties explaining the observed faintness. However, the upper limits
are consistent with modern ALMA and VLA observations. Our upper limits provide
further evidence for a spectral peak at and
constrain the number density of electrons in the accretion
disk and or outflow.Comment: accepted for publication in AP
Overexpression of Inosine 5′-Monophosphate Dehydrogenase Type II Mediates Chemoresistance to Human Osteosarcoma Cells
overexpression in osteosarcoma patients with poor response to chemotherapy. The aim of this study was to provide evidence for direct involvement of IMPDH2 in the development of chemoresistance..IMPDH2 is directly involved in the development of chemoresistance in osteosarcoma cells, suggesting that targeting of IMPDH2 by RNAi or more effective pharmacological inhibitors in combination with chemotherapy might be a promising means of overcoming chemoresistance in osteosarcomas with high IMPDH2 expression
Optical Distortion in the NACO Imager
In this research note, we present a set of distortion solutions that may be
used to correct geometric optical distortion in images taken with the S13
camera of the NACO adaptive optics imager.Comment: published in the RNAA
Sgr A* near-infrared flares from reconnection events in a magnetically arrested disc
Large-amplitude Sgr A* near-infrared flares result from energy injection into
electrons near the black hole event horizon. Astrometry data show continuous
rotation of the emission region during bright flares, and corresponding
rotation of the linear polarization angle. One broad class of physical flare
models invokes magnetic reconnection. Here we show that such a scenario can
arise in a general relativistic magnetohydrodynamic simulation of a
magnetically arrested disc. Saturation of magnetic flux triggers eruption
events, where magnetically dominated plasma is expelled from near the horizon
and forms a rotating, spiral structure. Dissipation occurs via reconnection at
the interface of the magnetically dominated plasma and surrounding fluid. This
dissipation is associated with large increases in near-infrared emission in
models of Sgr A*, with durations and amplitudes consistent with the observed
flares. Such events occur at roughly the timescale to re-accumulate the
magnetic flux from the inner accretion disc, 10h for Sgr A*. We study
near-infrared observables from one sample event to show that the emission
morphology tracks the boundary of the magnetically dominated region. As the
region rotates around the black hole, the near-infrared centroid and linear
polarization angle both undergo continuous rotation, similar to the behavior
seen in Sgr A* flares.Comment: revised version, MNRAS, in pres
What stellar orbit is needed to measure the spin of the Galactic center black hole from astrometric data?
Astrometric and spectroscopic monitoring of individual stars orbiting the
supermassive black hole in the Galactic Center offer a promising way to detect
general relativistic effects. While low-order effects are expected to be
detected following the periastron passage of S2 in Spring 2018, detecting
higher-order effects due to black hole spin will require the discovery of
closer stars. In this paper, we set out to determine the requirements such a
star would have to satisfy to allow the detection of black hole spin. We focus
on the instrument GRAVITY, which saw first light in 2016 and which is expected
to achieve astrometric accuracies as. For an observing campaign
with duration years, total observations, astrometric precision
and normalized black hole spin , we find that
is needed. For and a potential observing
campaign with as, 30 observations/year and duration 4-10
years, we expect star with satisfying this constraint based
on the current knowledge about the stellar population in the central 1". We
also propose a method through which GRAVITY could potentially measure radial
velocities with precision km/s. If the astrometric precision can be
maintained, adding radial velocity information increases the expected number of
stars by roughly a factor of two. While we focus on GRAVITY, the results can
also be scaled to parameters relevant for future extremely large telescopes.Comment: Accepted to MNRA
Phenotype of autosomal dominant spastic paraplegia linked to chromosome 2
Summary We report the clinical features of 12 families with autosomal dominant spastic paraplegia (ADSP) linked to the SPG4 locus on chromosome 2p, the major locus for this disorder that accounts for ∼40% of the families. Among 93 gene carriers, 32 (34%) were unaware of symptoms but were clinically affected. Haplotype reconstruction showed that 90% of the asymptomatic gene carriers presented increased reflexes and/or extensor plantar responses independent of age at examination. The mean age at onset was 29 years, ranging from 1 to 63 years. Intra- as well as inter-familial variability of age at onset was important, but did not result from anticipation. Phenotype—genotype correlations and comparison with SPG3 and SPG5 families indicated that despite the variability of age at onset, SPG4 is a single genetic entity but no clinical features distinguish individual SPG4 patients from those with SPG3 or SPG5 mutation
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