Momordica charantia, a nutraceutical approach for inflammatory related diseases

Momordica charantia, commonly called bitter melon, is a plant belonging to Cucurbitaceae family known for centuries for its pharmacological activities, and nutritional properties. Due to the presence of many bioactive compounds, some of which possess potent biological actions, this plant is used in folk medicine all over the world for the treatment of different pathologies, mainly diabetes, but also cancer, and other inflammation-associated diseases. It is widely demonstrated that M. charantia extracts contribute in lowering glycaemia in patients affected by type 2 diabetes. However, the majority of existing studies on M. charantia bioactive compounds were performed only on cell lines and in animal models. Therefore, because the real impact of bitter melon on human health has not been thoroughly demonstrated, systematic clinical studies are needed to establish its efficacy and safety in patients. Besides, both in vitro and in vivo studies have demonstrated that bitter melon may also elicit toxic or adverse effects under different conditions. The aim of this review is to provide an overview of anti-inflammatory and anti-neoplastic properties of bitter melon, discussing its pharmacological activity as well as the potential adverse effects. Even if a lot of literature is available about bitter melon as antidiabetic drug, few papers discuss the anti-inflammatory and anti-cancer properties of this plant

A New Derivation of the CPT and Spin-Statistics Theorems in Non-Commutative Field Theories

We propose an alternative axiomatic description for non-commutative field theories (NCFT) based on some ideas by Soloviev to nonlocal quantum fields. The local commutativity axiom is replaced by the weaker condition that the fields commute at sufficiently large spatial separations, called asymptotic commutativity, formulated in terms of the theory of analytic functionals. The question of a possible violation of the CPT and Spin-Statistics theorems caused by nonlocality of the commutation relations $[\hat{x}_\mu,\hat{x}_\nu]=i\theta_{\mu\nu}$ is investigated. In spite of this inherent nonlocality, we show that the modification aforementioned is sufficient to ensure the validity of these theorems for NCFT. We restrict ourselves to the simplest model of a scalar field in the case of only space-space non-commutativity.Comment: The title is new, and the analysis in the manuscript has been made more precise. This revised version is to be published in J.Math.Phy

A pilot study on yearlings' reactions to handling in relation to the training method

Handling and training methods of horses, which specially emphasize the importance of understanding horse body language and the use of reinforcements, are often used in practice, yet their effects are not completely known. This study investigated whether the use of a sympathetic approach during the preparation for public auctions influenced the reactivity of young horses towards humans. Sixteen thoroughbred yearlings were prepared for the public auctions during one month: eight horses ("Control") were handled according to conventional practices, while the others ("Treated") were handled with two sessions of basic training based on body language. The reactivity of horses was assessed in the presence of an "unfamiliar person" and a "familiar person" inside the horse's box. The experimenter recorded the presence/absence of selected behaviors during seven observational moments: "approaching the box," "opening the box door," "entering the box," and four consecutive observations every thirty seconds. Reactivity of horses was ranked during the first experience of "bit," "grooming," "shower," and application of the "surcingle." Heart rate was telemetrically recorded during this final test. At the end of the auction preparation, "Treated" horses exhibited more "contact" (p = 0.08) and "lick" (p < 0.05) behaviors in the presence of a person. "Control" horses showed higher (non-significant) percentages of negative (more nervous) rankings during "bit," "grooming," and "surcingle" tests. Two "Control" horses showed aggressive behavior during the application of the surcingle and the test was interrupted to guarantee person and animal safety. In this pilot study, horses handled with a sympathetic approach showed less reactive behaviors compared with "Control" horses. It would be interesting to enlarge the sample size and assess if the use of non-coercive handling during the whole training period influences their welfare positively and for a long time

Chronic kidney disease: Which role for xanthine oxidoreductase activity and products?

The present review explores the role of xanthine oxidoreductase (XOR) in the development and progression of chronic kidney disease (CKD). Human XOR is a multi-level regulated enzyme, which has many physiological functions, but that is also implicated in several pathological processes. The main XOR activities are the purine catabolism, which generates uric acid, and the regulation of cell redox state and cell signaling, through the production of reactive oxygen species. XOR dysregulation may lead to hyperuricemia and oxidative stress, which could have a pathogenic role in the initial phases of CKD, by promoting cell injury, hypertension, chronic inflammation and metabolic derangements. Hypertension is common in CKD patients and many mechanisms inducing it (upregulation of renin-angiotensin-aldosterone system, endothelial dysfunction and atherosclerosis) may be influenced by XOR products. High XOR activity and hyperuricemia are also risk factors for obesity, insulin resistance, type 2 diabetes and metabolic syndrome that are frequent CKD causes. Moreover, CKD is common in patients with gout, which is characterized by hyperuricemia, and in patients with cardiovascular diseases, which are associated with hypertension, endothelial dysfunction and atherosclerosis. Although hyperuricemia is undoubtedly related to CKD, controversial findings have been hitherto reported in patients treated with urate-lowering therapies

Exploring the relationship between microdosing, personality and emotional insight: A prospective study

Backround and aims: Having entered the recent public and research zeitgeist, microdosing involves consuming sub-perceptual doses of psychedelic drugs, allegedly to enhance performance, creativity, and wellbeing. The results of research to date have been mixed. Whereas most studies have reported positive impacts of microdosing, some microdosers have also reported adverse effects. In addition, research to date has revealed inconsistent patterns of change in personality traits. This prospective study explored the relationship between microdosing, personality change, and emotional awareness. Methods: Measures of personality and alexithymia were collected at two time points. 76 microdosers participated at baseline. Invitations to a follow-up survey were sent out after 31 days, and 24 participants were retained. Results: Conscientiousness increased, while neuroticism decreased across these time points (n 5 24). At baseline (N 5 76), neuroticism was associated with alexithymia. In addition, neuroticism correlated negatively with duration of prior microdosing experience, and extraversion correlated positively with both duration of prior microdosing experience and lifetime number of microdoses. Conclusion: These results suggest that microdosing might have an impact on otherwise stable personality traits