1,098 research outputs found
THE USE OF COMBINED PRESERVATION TECHNIQUES FOR EXTENDED STORAGE OF ORTHOTOPIC LIVER HOMOGRAFTS.
Paradoxical increase in the PPG amplitude
Background : Although an increase in sympathetic nerve activity is generally associated with a decrease in the photoplethysmography (PPG) amplitude, the present case study demonstrates that nociceptive stimuli, such as tracheal intubation, paradoxically induce an increase in PPG amplitude. To the best of our knowledge, this is the first study to capture an increase in the PPG amplitude in response to sympathetic nerve activation. Case presentation : A 73-year-old woman underwent open surgery. Following anesthesia induction, tracheal intubation was performed, which resulted in increased heart rate and raised blood pressure. While nociception usually decreases the PPG amplitude, the opposite was found. Conversely, the vascular stiffness K value, our research group’s unique monitoring method to quantify the strength of sympathetic activity, increased reflecting increased peripheral vascular resistance. Conclusions : We report a paradoxical case of increased PPG amplitude following tracheal intubation. It is important to note that the PPG amplitude does not always decrease with nociceptive stimuli
Influence of tunneling on electron screening in low energy nuclear reactions in laboratories
Using a semiclassical mean field theory, we show that the screening potential
exhibits a characteristic radial variation in the tunneling region in sharp
contrast to the assumption of the constant shift in all previous works. Also,
we show that the explicit treatment of the tunneling region gives a larger
screening energy than that in the conventional approach, which studies the time
evolution only in the classical region and estimates the screening energy from
the screening potential at the external classical turning point. This
modification becomes important if the electronic state is not a single
adiabatic state at the external turning point either by pre-tunneling
transitions of the electronic state or by the symmetry of the system even if
there is no essential change with the electronic state in the tunneling region.Comment: 3 figure
Influence of Tunneling on Electron Screening in Low Energy Nuclear Reactions
Using a semiclassical mean field theory, we show that the screening potential exhibits a characteristic radial variation in the tunneling region in sharp contrast to the assumption of the constant shift in all previous works. Also, we show that the explicit treatment of the tunneling region gives a larger screening energy than that in the conventional approach, which studies the time evolution only in the classical region and estimates the screening energy from the screening potential at the external classical turning point. This modification becomes important if the electronic state is not a single adiabatic state at the external turning point. Furthermore, as an alternative solution of the screening problem, we give the estimation for the effect of extra electrons which are caught into the ground state of the projectile by using constraint molecular dynamics
Trypanosoma evansi ima gen sličan genu za oligosaharil-transferazu klona I protozoona Trypanosoma brucei rhodesiense.
Recent data has shown that there are strong indications that the putative oligosaccharyl transferase genes from Trypanosoma brucei rhodesiense were conserved within the family Trypanosomatidae. Based on these findings, the study endeavored to determine if Trypanosoma evansi also possessed putative oligosaccharyl transferase (OST) clone I previously documented in Trypanosoma brucei rhodesiense. Using the DNA hybridization method (Southern blot analyses), genomic DNAs of Trypanosoma brucei rhodesiense and Trypanosoma evansi were processed using the same set of restriction enzymes and subsequently hybridized by the same set of DNA probes designed from the reported nucleotide sequence of Trypanosoma brucei rhodesiense putative oligosaccharyl transferase clone I. The results exhibited that Trypanosoma evansi also contains a gene similar to the reported Trypanosoma brucei rhodesiense putative OST gene clone I, as shown by the successful hybridization of the DNA probes to their complementary nucleotide sequences in the genome of the Trypanosoma evansi species. In addition, the data also showed that Trypanosoma brucei rhodesiense and Trypanosoma evansi genomes shared some common restriction sites and loci within the genome of each individual parasite species.Nedavna istraživanja pokazala su da su geni za oligosaharil transferazu protozoona Trypanosoma brucei rhodesiense vrlo dobro sačuvani unutar porodice Trypanosomatidae. Cilj istraživanja bio je otkriti je li ista pojava karakteristična za gen za oligosaharil transferazu klona I protozoona Trypanosoma evansi. Genomske DNA vrste Trypanosoma brucei rhodesiense i vrste Trypanosoma evansi bile su pretražene hibridizacijom DNA (Southern Blot analizom) rabeći istu skupinu restrikcijskih enzima kao i iste probe za hibridizaciju DNA pripravljene na temelju objavljenog slijeda nukleotida za oligosaharil-transferazu klona I protozoona Trypanosoma brucei rhodesiense. Rezultati su pokazali da Trypanosoma evansi također sadrži gen koji je vrlo sličan genu za oligosaharil-transferazu protozoona Trypanosoma brucei rhodesiense, što je dokazano uspješnom hibridizacijom DNA proba s komplementarnim nukleotidnim slijedovima u genomu vrste Trypanosoma evansi. Istraživanje je pokazalo da Trypanosoma brucei rhodesiense i Trypanosoma evansi dijele i zajednička restrikcijska mjesta
Structural and functional conservation of key domains in InsP3 and ryanodine receptors.
Inositol-1,4,5-trisphosphate receptors (InsP(3)Rs) and ryanodine receptors (RyRs) are tetrameric intracellular Ca(2+) channels. In each of these receptor families, the pore, which is formed by carboxy-terminal transmembrane domains, is regulated by signals that are detected by large cytosolic structures. InsP(3)R gating is initiated by InsP(3) binding to the InsP(3)-binding core (IBC, residues 224-604 of InsP(3)R1) and it requires the suppressor domain (SD, residues 1-223 of InsP(3)R1). Here we present structures of the amino-terminal region (NT, residues 1-604) of rat InsP(3)R1 with (3.6 Å) and without (3.0 Å) InsP(3) bound. The arrangement of the three NT domains, SD, IBC-β and IBC-α, identifies two discrete interfaces (α and β) between the IBC and SD. Similar interfaces occur between equivalent domains (A, B and C) in RyR1 (ref. 9). The orientations of the three domains when docked into a tetrameric structure of InsP(3)R and of the ABC domains docked into RyR are remarkably similar. The importance of the α-interface for activation of InsP(3)R and RyR is confirmed by mutagenesis and, for RyR, by disease-causing mutations. Binding of InsP(3) causes partial closure of the clam-like IBC, disrupting the β-interface and pulling the SD towards the IBC. This reorients an exposed SD loop ('hotspot' (HS) loop) that is essential for InsP(3)R activation. The loop is conserved in RyR and includes mutations that are associated with malignant hyperthermia and central core disease. The HS loop interacts with an adjacent NT, suggesting that activation re-arranges inter-subunit interactions. The A domain of RyR functionally replaced the SD in full-length InsP(3)R, and an InsP(3)R in which its C-terminal transmembrane region was replaced by that from RyR1 was gated by InsP(3) and blocked by ryanodine. Activation mechanisms are conserved between InsP(3)R and RyR. Allosteric modulation of two similar domain interfaces within an N-terminal subunit reorients the first domain (SD or A domain), allowing it, through interactions of the second domain of an adjacent subunit (IBC-β or B domain), to gate the pore
Anonymization server system for DICOM images
We have developed an anonymization system for DICOM images. It requires consent from the patient to use the DICOM images for research or education. However, providing the DICOM image to the other facilities is not safe because it contains a lot of personal data. Our system is a server that provides anonymization service of DICOM images for users in the facility. The distinctive features of the system are, input interface, flexible anonymization policy, and automatic body part identification. In the first feature, we can use the anonymization service on the existing DICOM workstations. In the second feature, we can select a best policy fitting for the Protection of personal data that is ruled by each medical facility. In the third feature, we can identify the body parts that are included in the input image set, even if the set lacks the body part tag in DICOM header. We installed the system for the first time to a hospital in December 2005. Currently, the system is working in other four facilities. In this paper we describe the system and how it works
Twisted Superspace for N=D=2 Super BF and Yang-Mills with Dirac-K\"ahler Fermion Mechanism
We propose a twisted D=N=2 superspace formalism. The relation between the
twisted super charges including the BRST charge, vector and pseudo scalar super
charges and the N=2 spinor super charges is established. We claim that this
relation is essentially related with the Dirac-K\"ahler fermion mechanism. We
show that a fermionic bilinear form of twisted N=2 chiral and anti-chiral
superfields is equivalent to the quantized version of BF theory with the Landau
type gauge fixing while a bosonic bilinear form leads to the N=2 Wess-Zumino
action. We then construct a Yang-Mills action described by the twisted N=2
chiral and vector superfields, and show that the action is equivalent to the
twisted version of the D=N=2 super Yang-Mills action, previously obtained from
the quantized generalized topological Yang-Mills action with instanton gauge
fixing.Comment: 36 page
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