17 research outputs found
Analysis of single-mode efficiency of electrically pumped VECSELs
We present a model and results of simulations and experiments investigating the L-I characteristics of electrically pumped (EP-) VECSELs in the single- and multi-mode regime. In our model we use a mode expansion ansatz to treat the electromagnetic field inside the VECSEL cavity. The eigenmodes of the passive cavity are computed using the bidirectional beam propagation method (BDBPM) to solve the Helmholtz equation. The BDBPM allows us to account for the complex refractive index distribution within the semiconductor heterostucture, composed of approximately thousand interfaces along the optical axis in addition to lateral refractive index variations in oxide-confined devices as well as the macroscopic external cavity. We simulate the time evolution of the modal powers of several transverse modes and the spatial distribution of the inversion carriers in the quantum well plane. Therefore we solve an differential equation system composed of multimode rate equations and the carrier diffusion equation. With this ansatz we are able to identify cavity geometries suitable for single-mode operation assuming typical current profiles that are taken from photoluminescence measurements of the devices under investigation. Furthermore, we identify effects limiting the single-mode efficiency, such as poor gain and mode matching, reabsorption in unpumped regions of the quantum wells or enhanced carrier losses due to strong spatial hole burning. Critical parameters of the equations, such as optical losses, injection effciency, carrier recombination constants and gain parameters are obtained from experiments, microscopic models and literature. The simulation results are compared to experimental results from EP-VECSELs from Philips Technologie GmbH U-L-M Photonics
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Comparison of Islet Characterization from Use of Standard Crude Collagenase to GMP-Grade Collagenase Enzyme Blends in Preweaned Porcine Islet Isolations.
For the advancement of porcine xenotransplantation for clinical use in type 1 diabetes mellitus, the concerns of a sustainable and safe digestion enzyme blend must be overcome. Incorporating good manufacturing practices (GMP) can facilitate this through utilizing GMP-grade enzymes. In conjunction, still taking into account the cost-effectiveness, a wide concern. We evaluated how GMP-grade enzyme blends impact our piglet islets and their long-term effects. âPreweaned porcine islets (PPIs) were isolated from 8- to 10-day-old pigs. Digestion enzyme blends, collagenase type V (Type V), collagenase AF-1 GMP-grade with collagenase NB 6 GMP-grade (AF-1 and NB 6), and collagenase AF-1 GMP-grade with collagenase neutral protease AF GMP-grade (AF-1 and NP AF) were compared. Islet quality control assessments, islet yield, viability, and function, were performed on days 3 and 7, and cell content was performed on day 7. âGMP-grade AF-1 and NB 6 (17,209 ± 2,730 islet equivalent per gram of pancreatic tissue [IE/g] on day 3, 9,001 ± 1,034 IE/g on day 7) and AF-1 and NP AF (17,214 ± 3,901 IE/g on day 3, 8,833 ± 2,398 IE/g on day 7) showed a significant increase in islet yield compared to Type V (4,618 ± 1,240 IE/g on day 3, 1,923 ± 704 IE/g on day 7). Islet size, viability, and function showed comparable results in all enzyme blends. There was no significant difference in islet cellular content between enzyme blends. âThis study demonstrated a comparison of GMP-grade collagenase enzyme blends and a standard crude collagenase enzyme in preweaned-aged porcine, a novel topic in this age. GMP-grade enzyme blends of AF-1 and NB 6 and AF-1 and NP AF resulted in substantially higher yields and as effective PPIs compared to Type V. In the long run, considering costs, integrity, and sustainability, GMP-grade enzyme blends are more favorable for clinical application due to high reproducibility in comparison to undefined manufacturing processes of standard enzymes
Edge currents driven by terahertz radiation in graphene in quantum Hall regime
We observe that the illumination of unbiased graphene in the quantum Hall regime with polarized terahertz laser radiation results in a direct edge current. This photocurrent is caused by an imbalance of persistent edge currents, which are driven out of thermal equilibrium by indirect transitions within the chiral edge channel. The direction of the edge photocurrent is determined by the polarity of the external magnetic field, while its magnitude depends on the radiation polarization. The microscopic theory developed in this paper describes well the experimental data
GP-related genes with fold change>1.5 up-regulated expression in the sorted CD177<sup>â</sup> neutrophil subset as compared to the CD177<sup>+</sup> subset.
<p>GP-related genes with fold change>1.5 up-regulated expression in the sorted CD177<sup>â</sup> neutrophil subset as compared to the CD177<sup>+</sup> subset.</p
Characteristics of patients and healthy controls included in the analysis of granule proteins-related gene expression by RT-PCR.
<p>HC: healthy controls; GPA: Patients with granulomatosis with polyangiitis; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; ND: not determined.</p