Adaptive evolution of molecular phenotypes

Molecular phenotypes link genomic information with organismic functions, fitness, and evolution. Quantitative traits are complex phenotypes that depend on multiple genomic loci. In this paper, we study the adaptive evolution of a quantitative trait under time-dependent selection, which arises from environmental changes or through fitness interactions with other co-evolving phenotypes. We analyze a model of trait evolution under mutations and genetic drift in a single-peak fitness seascape. The fitness peak performs a constrained random walk in the trait amplitude, which determines the time-dependent trait optimum in a given population. We derive analytical expressions for the distribution of the time-dependent trait divergence between populations and of the trait diversity within populations. Based on this solution, we develop a method to infer adaptive evolution of quantitative traits. Specifically, we show that the ratio of the average trait divergence and the diversity is a universal function of evolutionary time, which predicts the stabilizing strength and the driving rate of the fitness seascape. From an information-theoretic point of view, this function measures the macro-evolutionary entropy in a population ensemble, which determines the predictability of the evolutionary process. Our solution also quantifies two key characteristics of adapting populations: the cumulative fitness flux, which measures the total amount of adaptation, and the adaptive load, which is the fitness cost due to a population's lag behind the fitness peak.Comment: Figures are not optimally displayed in Firefo

Mid-Infrared Ethane Emission on Neptune and Uranus

We report 8- to 13-micron spectral observations of Neptune and Uranus from the NASA Infrared Telescope Facility spanning more than a decade. The spectroscopic data indicate a steady increase in Neptune's mean atmospheric 12-micron ethane emission from 1985 to 2003, followed by a slight decrease in 2004. The simplest explanation for the intensity variation is an increase in stratospheric effective temperature from 155 +/- 3 K in 1985 to 176 +/- 3 K in 2003 (an average rate of 1.2 K/year), and subsequent decrease to 165 +/- 3 K in 2004. We also detected variation of the overall spectral structure of the ethane band, specifically an apparent absorption structure in the central portion of the band; this structure arises from coarse spectral sampling coupled with a non-uniform response function within the detector elements. We also report a probable direct detection of ethane emission on Uranus. The deduced peak mole fraction is approximately an order of magnitude higher than previous upper limits for Uranus. The model fit suggests an effective temperature of 114 +/- 3 K for the globally-averaged stratosphere of Uranus, which is consistent with recent measurements indicative of seasonal variation.Comment: Accepted for publication in ApJ. 16 pages, 10 figures, 2 table

Non-diffusive transport in plasma turbulence: a fractional diffusion approach

Numerical evidence of non-diffusive transport in three-dimensional, resistive pressure-gradient-driven plasma turbulence is presented. It is shown that the probability density function (pdf) of test particles' radial displacements is strongly non-Gaussian and exhibits algebraic decaying tails. To model these results we propose a macroscopic transport model for the pdf based on the use of fractional derivatives in space and time, that incorporate in a unified way space-time non-locality (non-Fickian transport), non-Gaussianity, and non-diffusive scaling. The fractional diffusion model reproduces the shape, and space-time scaling of the non-Gaussian pdf of turbulent transport calculations. The model also reproduces the observed super-diffusive scaling

Some 5-13 micrometer airborne observations of Comet Wilson 1986l: Preliminary results

Comet Wilson was observed from the Kuiper Airborne Observatory approximately 23.6 and 25.7 Apr. 1987, UT (approx. 3 to 5 days after perihelion) using the NASA-Ames Faint Object Grating Spectrometer. Spectrophotometric data were observed with a 21 inch aperture between 5 and 13 micrometer and with a spectral resolution of 50 to 100. Spectra of the inner coma and nucleus reveal a fairly smooth continuum with little evidence of silicate emission. The 5 to 8 micrometer color temperature of the comet was 300 + or - 15 K, approx. 15 percent higher than the equilibrium blackbody temperature. All three spectra of the nucleus show a new emission feature at approx. 12.25 micrometer approx. two channels (.22 micrometer) wide. Visual and photographic observations made during the time of these observations showed a broad faint, possible two component tail. No outburst activity was observed

Reflections on the Occasion of the 100th Anniversary of the Monthly Labor Review

It is an honor to comment on directions for the Monthly Labor Review MLR over its next 25 years. The MLR is the federal government\u27s oldest continuous publication—first printed in 1915 and now published online by the Bureau of Labor Statistics (BLS), one of the nation\u27s oldest statistical agencies, established in 1884. BLS embodies the standards articulated by the Committee on National Statistics (CNSTAT) in the fifth edition of its quadrennial volume Principles and Practices for a Federal Statistical Agency (National Research Council, 2013). P&P lays down four principles: that a statistical agency produce data relevant to policy issues, earn credibility with data users, earn the trust of data providers (e.g., households, businesses), and maintain independence from political and other undue external influence

Exposure to atmospheric radon.

We measured radon (222Rn) concentrations in Iowa and Minnesota and found that unusually high annual average radon concentrations occur outdoors in portions of central North America. In some areas, outdoor concentrations exceed the national average indoor radon concentration. The general spatial patterns of outdoor radon and indoor radon are similar to the spatial distribution of radon progeny in the soil. Outdoor radon exposure in this region can be a substantial fraction of an individual's total radon exposure and is highly variable across the population. Estimated lifetime effective dose equivalents for the women participants in a radon-related lung cancer study varied by a factor of two at the median dose, 8 mSv, and ranged up to 60 mSv (6 rem). Failure to include these doses can reduce the statistical power of epidemiologic studies that examine the lung cancer risk associated with residential radon exposure

An Improved Approximate Consensus Algorithm in the Presence of Mobile Faults

This paper explores the problem of reaching approximate consensus in synchronous point-to-point networks, where each pair of nodes is able to communicate with each other directly and reliably. We consider the mobile Byzantine fault model proposed by Garay '94 -- in the model, an omniscient adversary can corrupt up to $f$ nodes in each round, and at the beginning of each round, faults may "move" in the system (i.e., different sets of nodes may become faulty in different rounds). Recent work by Bonomi et al. '16 proposed a simple iterative approximate consensus algorithm which requires at least $4f+1$ nodes. This paper proposes a novel technique of using "confession" (a mechanism to allow others to ignore past behavior) and a variant of reliable broadcast to improve the fault-tolerance level. In particular, we present an approximate consensus algorithm that requires only $\lceil 7f/2\rceil + 1$ nodes, an $\lfloor f/2 \rfloor$ improvement over the state-of-the-art algorithms. Moreover, we also show that the proposed algorithm is optimal within a family of round-based algorithms