156 research outputs found
Hardy's inequality for functions vanishing on a part of the boundary
We develop a geometric framework for Hardy's inequality on a bounded domain
when the functions do vanish only on a closed portion of the boundary.Comment: 26 pages, 2 figures, includes several improvements in Sections 6-8
allowing to relax the assumptions in the main results. Final version
published at http://link.springer.com/article/10.1007%2Fs11118-015-9463-
Treatment of rheumatoid arthritis: a global perspective on the use of antirheumatic drugs
Modern therapy for rheumatoid arthritis (RA) is based on knowledge of the severity of the natural history of the disease. RA patients are approached with early and aggressive treatment strategies, methotrexate as an anchor drug, biological targeted therapies in those with inadequate response to methotrexate, and “tight control,” aiming for remission and low disease activity according to quantitative monitoring. This chapter presents a rationale for current treatment strategies for RA with antirheumatic drugs, a review of published reports concerning treatments in clinical cohorts outside of clinical trials, and current treatments at 61 sites in 21 countries in the QUEST-RA database
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