Severe Cholestasis Associated with Methyltestosterone: A Case Report

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75504/1/j.1572-0241.1987.tb01706.x.pd

A Cepheid Distance to NGC 4603 in Centaurus

In an attempt to use Cepheid variables to determine the distance to the Centaurus cluster, we have obtained images of NGC 4603 with the Hubble Space Telescope on 9 epochs using WFPC2 and the F555W and F814W filters. This galaxy has been suggested to lie within the ``Cen30'' portion of the cluster and is the most distant object for which this method has been attempted. Previous distance estimates for Cen30 have varied significantly and some have presented disagreements with the peculiar velocity predicted from redshift surveys, motivating this investigation. Using our observations, we have found 61 candidate Cepheid variable stars; however, a significant fraction of these candidates are likely to be nonvariable stars whose magnitude measurement errors happen to fit a Cepheid light curve of significant amplitude for some choice of period and phase. Through a maximum likelihood technique, we determine that we have observed 43 +/- 7 real Cepheids and that NGC 4603 has a distance modulus of 32.61 +0.11/-0.10 (random, 1 sigma) +0.24/-0.25 (systematic, adding in quadrature), corresponding to a distance of 33.3 Mpc. This is consistent with a number of recent estimates of the distance to NGC 4603 or Cen30 and implies a small peculiar velocity consistent with predictions from the IRAS 1.2 Jy redshift survey if the galaxy lies in the foreground of the cluster.Comment: Accepted for publication in the Astrophysical Journal. 17 pages with 17 embedded figures and 3 tables using emulateapj.sty. Additional figures and images may be obtained from http://astro.berkeley.edu/~marc/n4603

POTENT Reconstruction from Mark III Velocities

We present an improved POTENT method for reconstructing the velocity and mass density fields from radial peculiar velocities, test it with mock catalogs, and apply it to the Mark III Catalog. Method improvments: (a) inhomogeneous Malmquist bias is reduced by grouping and corrected in forward or inverse analyses of inferred distances, (b) the smoothing into a radial velocity field is optimized to reduce window and sampling biases, (c) the density is derived from the velocity using an improved nonlinear approximation, and (d) the computational errors are made negligible. The method is tested and optimized using mock catalogs based on an N-body simulation that mimics our cosmological neighborhood, and the remaining errors are evaluated quantitatively. The Mark III catalog, with ~3300 grouped galaxies, allows a reliable reconstruction with fixed Gaussian smoothing of 10-12 Mpc/h out to ~60 Mpc/h. We present maps of the 3D velocity and mass-density fields and the corresponding errors. The typical systematic and random errors in the density fluctuations inside 40 Mpc/h are \pm 0.13 and \pm 0.18. The recovered mass distribution resembles in its gross features the galaxy distribution in redshift surveys and the mass distribution in a similar POTENT analysis of a complementary velocity catalog (SFI), including the Great Attractor, Perseus-Pisces, and the void in between. The reconstruction inside ~40 Mpc/h is not affected much by a revised calibration of the distance indicators (VM2, tailored to match the velocities from the IRAS 1.2Jy redshift survey). The bulk velocity within the sphere of radius 50 Mpc/h about the Local Group is V_50=370 \pm 110 km/s (including systematic errors), and is shown to be mostly generated by external mass fluctuations. With the VM2 calibration, V_50 is reduced to 305 \pm 110 km/s.Comment: 60 pages, LaTeX, 3 tables and 27 figures incorporated (may print the most crucial figures only, by commenting out one line in the LaTex source

ROSAT PSPC Observations of the Richest (R≥2R \geq 2) ACO Clusters

We have compiled an X-ray catalog of optically selected rich clusters of galaxies observed by the PSPC during the pointed GO phase of the ROSAT mission. This paper contains a systematic X-ray analysis of 150 clusters with an optical richness classification of $R \geq 2$ from the ACO catalog (Abell, Corwin, and Olowin 1989). All clusters were observed within 45' of the optical axis of the telescope during pointed PSPC observations. For each cluster, we calculate: the net 0.5-2.0 keV PSPC count rate (or $4 \sigma$ upper limit) in a 1 Mpc radius aperture, 0.5-2.0 keV flux and luminosity, bolometric luminosity, and X-ray centroid. The cluster sample is then used to examine correlations between the X-ray and optical properties of clusters, derive the X-ray luminosity function of clusters with different optical classifications, and obtain a quantitative estimate of contamination (i.e, the fraction of clusters with an optical richness significantly overestimated due to interloping galaxies) in the ACO catalog

The development and evaluation of exercises in meaningful word practice in grade one

Research chapter for this study will be found in Ash, Dorothea: "Development and evaluation of silent reading exercises in grade one" Thesis (Ed.M.)--Boston Universit

The development and evaluation of exercises in meaningful word practice in grade one

Research chapter for this study will be found in Ash, Dorothea: "Development and evaluation of silent reading exercises in grade one" Thesis (Ed.M.)--Boston Universit

The Dipole Anisotropy of the First All-Sky X-ray Cluster Sample

We combine the recently published CIZA galaxy cluster catalogue with the XBACs cluster sample to produce the first all-sky catalogue of X-ray clusters in order to examine the origins of the Local Group's peculiar velocity without the use of reconstruction methods to fill the traditional Zone of Avoidance. The advantages of this approach are (i) X-ray emitting clusters tend to trace the deepest potential wells and therefore have the greatest effect on the dynamics of the Local Group and (ii) our all-sky sample provides data for nearly a quarter of the sky that is largely incomplete in optical cluster catalogues. We find that the direction of the Local Group's peculiar velocity is well aligned with the CMB as early as the Great Attractor region 40 h^-1 Mpc away, but that the amplitude of its dipole motion is largely set between 140 and 160 h^-1 Mpc. Unlike previous studies using galaxy samples, we find that without Virgo included, roughly ~70% of our dipole signal comes from mass concentrations at large distances (>60 h^-1 Mpc) and does not flatten, indicating isotropy in the cluster distribution, until at least 160 h^-1 Mpc. We also present a detailed discussion of our dipole profile, linking observed features to the structures and superclusters that produce them. We find that most of the dipole signal can be attributed to the Shapley supercluster centered at about 150 h^-1 Mpc and a handful of very massive individual clusters, some of which are newly discovered and lie well in the Zone of Avoidance.Comment: 15 Pages, 9 Figures. Accepted by Ap

Ribosomal Proteins RPS11 and RPS20, Two Stress-Response Markers of Glioblastoma Stem Cells, Are Novel Predictors of Poor Prognosis in Glioblastoma Patients.

Glioblastoma stem cells (GSC) co-exhibiting a tumor-initiating capacity and a radio-chemoresistant phenotype, are a compelling cell model for explaining tumor recurrence. We have previously characterized patient-derived, treatment-resistant GSC clones (TRGC) that survived radiochemotherapy. Compared to glucose-dependent, treatment-sensitive GSC clones (TSGC), TRGC exhibited reduced glucose dependence that favor the fatty acid oxidation pathway as their energy source. Using comparative genome-wide transcriptome analysis, a series of defense signatures associated with TRGC survival were identified and verified by siRNA-based gene knockdown experiments that led to loss of cell integrity. In this study, we investigate the prognostic value of defense signatures in glioblastoma (GBM) patients using gene expression analysis with Probeset Analyzer (131 GBM) and The Cancer Genome Atlas (TCGA) data, and protein expression with a tissue microarray (50 GBM), yielding the first TRGC-derived prognostic biomarkers for GBM patients. Ribosomal protein S11 (RPS11), RPS20, individually and together, consistently predicted poor survival of newly diagnosed primary GBM tumors when overexpressed at the RNA or protein level [RPS11: Hazard Ratio (HR) = 11.5, p<0.001; RPS20: HR = 4.5, p = 0.03; RPS11+RPS20: HR = 17.99, p = 0.001]. The prognostic significance of RPS11 and RPS20 was further supported by whole tissue section RPS11 immunostaining (27 GBM; HR = 4.05, p = 0.01) and TCGA gene expression data (578 primary GBM; RPS11: HR = 1.19, p = 0.06; RPS20: HR = 1.25, p = 0.02; RPS11+RPS20: HR = 1.43, p = 0.01). Moreover, tumors that exhibited unmethylated O-6-methylguanine-DNA methyltransferase (MGMT) or wild-type isocitrate dehydrogenase 1 (IDH1) were associated with higher RPS11 expression levels [corr (IDH1, RPS11) = 0.64, p = 0.03); [corr (MGMT, RPS11) = 0.52, p = 0.04]. These data indicate that increased expression of RPS11 and RPS20 predicts shorter patient survival. The study also suggests that TRGC are clinically relevant cells that represent resistant tumorigenic clones from patient tumors and that their properties, at least in part, are reflected in poor-prognosis GBM. The screening of TRGC signatures may represent a novel alternative strategy for identifying new prognostic biomarkers

Redshifts and Velocity Dispersions of Galaxy Clusters in the Horologium-Reticulum Supercluster

We present 118 new optical redshifts for galaxies in 12 clusters in the Horologium-Reticulum supercluster (HRS) of galaxies. For 76 galaxies, the data were obtained with the Dual Beam Spectrograph on the 2.3m telescope of the Australian National University at Siding Spring Observatory. After combining 42 previously unpublished redshifts with our new sample, we determine mean redshifts and velocity dispersions for 13 clusters, in which previous observational data were sparse. In six of the 13 clusters, the newly determined mean redshifts differ by more than 750 km/s from the published values. In the case of three clusters, A3047, A3109, and A3120, the redshift data indicate the presence of multiple components along the line of sight. The new cluster redshifts, when combined with other reliable mean redshifts for clusters in the HRS, are found to be distinctly bi-modal. Furthermore, the two redshift components are consistent with the bi-modal redshift distribution found for the inter-cluster galaxies in the HRS by Fleenor et al. (2005).Comment: 13 pages, 3 figures, Accepted to A

Postimpact deformation associated with the late Eocene Chesapeake Bay impact structure in southeastern Virginia

Upper Cenozoic strata covering the Chesapeake Bay impact structure in southeastern Virginia record intermittent differential movement around its buried rim. Miocene strata in a graben detected by seismic surveys on the York River exhibit variable thickness and are deformed above the crater rim. Fan-like interformational and intraformational angular unconformities within Pliocene–Pleistocene strata, which strike parallel to the crater rim and dip2°–3° away from the crater center, indicate that deformation and deposition were synchronous.Concentric, large-scale crossbedded, bioclastic sand bodies of Pliocene age within ~20 km of the buried crater rim formed on offshore shoals, presumably as subsiding listric slump blocks rotated near the crater rim