Werkdruk, zingeving en burn-out bij predikanten in orthodox-gereformeerde kerken

research articleIn deze studie is bij drie kleinere orthodox gereformeerde kerkgenootschappen onderzoek gedaan naar burn-outverschijnselen onder predikanten in relatie tot werkdruk en existentiële zingeving. Van de 480 aangeschreven predikanten stuurden 280 een ingevuld formulier terug. Daarin waren opgenomen een itemlijst over werkdruk, de Existentieschaal over zingeving, ontwikkeld door leerlingen van V.E. Frankl, en de Utrechtse Burnoutschaal, aangepast voor predikanten. De respondenten bleken gemiddeld hoger te scoren op werkdruk en op alle drie dimensies van burn-out dan collega’s uit andere kerkgenootschappen in eerdere onderzoeken. De scores op werkdruk en op burn-out correleerden vrij hoog tot hoog met de scores op existentiële zingeving, in die zin dat hogere scores op de zingevingdimensies samenhingen met lagere scores op ervaren werkdruk en burn-out. De conclusie was, dat (gebrek aan) existentiële zingeving een belangrijke determinant van burn-out is, die tot op heden ten onrechte is verwaarloosd. In de preventie kan existentiële zingeving een zinvol en bruikbaar aanknopingspunt zijn voor gezondheidspsychologische interventies. Ten slotte zijn enkele aanbevelingen gedaan voor verder onderzoek

Feelings of Existential Fulfilment and Burnout Among Secondary School Teachers

Abstract Teacher burnout is recognized as a serious problem. In research it has been related to many person-specific variables; one of these, the variable of existential fulfilment, has received very little attention thus far. The present study focuses on the relationship between existential fulfilment and burnout among secondary school teachers in the Netherlands (N = 504). Existential fulfilment was made operational by means of the Existential Fulfilment Scale, which distinguishes between three dimensions: self-acceptance, self-actualization, and self-transcendence. A confirmatory factor analysis revealed a three-dimensional construct with interdependent dimensions. Burnout was measured by the Dutch version of the Maslach Burnout Inventory for teachers. Negative relationships between the existential fulfilment dimensions on the one hand and the burnout dimensions exhaustion and cynicism on the other were hypothesized, as well as positive relationships between the existential fulfilment dimensions and the burnout dimension professional efficacy. The hypotheses were confirmed, except for the relationships between self-transcendence and exhaustion and self-transcendence and cynicism, which appeared not to be significant. The inquiry demonstrated the importance of existential fulfilment for the prevalence and prevention of burnout among teachers. The study concludes with a discussion of the implications for future research

Conceptualization, Construction and Validation of the Existential Fulfilment Scale

research articleThis study presents the development and validation of the Existential Fulfilment Scale. Following Frankl’s concepts of life meaning and existential vacuum, the authors elaborate the construct of existential fulfilment. Three basic attitudes are distinguished, viz. selfacceptance, self-actualization, and self-transcendence, all of which deal with overcoming the conflicts caused by the human existential boundaries. A new scale has been developed out of Längle’s Existence Scale, the Existential Fulfilment Scale. Its advantage is that it distinguishes psychologically unhealthy, self-alienating purposes in life from healthy ones. Well-known measures such as Purpose in Life Test, Life Regard Inventory, and Sense of Coherence, fail to do so. The Existential Fulfilment Scale has been tested among 812 Dutch individuals. The results of a confirmatory factor analysis make clear that the three basic attitudes of existential fulfilment should be interpreted as distinct dimensions

Worldview and Psychotherapy: An Analysis of the Christian Integration Debate

Glas, G. [Promotor

Real-world keystroke dynamics are a potentially valid biomarker for clinical disability in multiple sclerosis

Background: Clinical measures in multiple sclerosis (MS) face limitations that may be overcome by utilising smartphone keyboard interactions acquired continuously and remotely during regular typing. Objective: The aim of this study was to determine the reliability and validity of keystroke dynamics to assess clinical aspects of MS. Methods: In total, 102 MS patients and 24 controls were included in this observational study. Keyboard interactions were obtained with the Neurokeys keyboard app. Eight timing-related keystroke features were assessed for reliability with intraclass correlation coefficients (ICCs); construct validity by analysing group differences (in fatigue, gadolinium-enhancing lesions on magnetic resonance imaging (MRI), and patients vs controls); and concurrent validity by correlating with disability measures. Results: Reliability was moderate in two (ICC = 0.601 and 0.742) and good to excellent in the remaining six features (ICC = 0.760–0.965). Patients had significantly higher keystroke latencies than controls. Latency between key presses correlated the highest with Expanded Disability Status Scale (r = 0.407) and latency between key releases with Nine-Hole Peg Test and Symbol Digit Modalities Test (ρ = 0.503 and r = −0.553, respectively), ps < 0.001. Conclusion: Keystroke dynamics were reliable, distinguished patients and controls, and were associated with clinical disability measures. Consequently, keystroke dynamics are a promising valid surrogate marker for clinical disability in MS

PPARγ deficiency results in reduced lung elastic recoil and abnormalities in airspace distribution

Background: Peroxisome proliferator-activated receptor (PPAR)-γ is a nuclear hormone receptor that regulates gene expression, cell proliferation and differentiation. We previously described airway epithelial cell PPARγ deficient mice that develop airspace enlargement with decreased tissue resistance and increased lung volumes. We sought to understand the impact of airspace enlargement in conditionally targeted mice upon the physio-mechanical properties of the lung. Methods: We measured elastic recoil and its determinants, including tissue structure and surface forces. We measured alveolar number using radial alveolar counts, and airspace sizes and their distribution using computer-assisted morphometry. Results: Air vs. saline-filled pressure volume profiles demonstrated loss of lung elastic recoil in targeted mice that was contributed by both tissue components and surface tension, but was proportional to lung volume. There were no significant differences in surfactant quantity/function nor in elastin and collagen content between targeted animals and littermate controls. Importantly, radial alveolar counts were significantly reduced in the targeted animals and at 8 weeks of age there were 18% fewer alveoli with 32% more alveolar ducts. Additionally, the alveolar ducts were 19% larger in the targeted animals. Conclusions: Our data suggest that the functional abnormalities, including loss of recoil are secondary to altered force transmission due to differences in the structure of alveolar ducts, rather than changes in surfactant function or elastin or collagen content. These data further define the nature of abnormal lung maturation in the absence of airway epithelial cell PPARγ and identify a putative genetic determinant of dysanapsis, which may serve as a precursor to chronic lung disease

Ran-dependent docking of importin-β to RanBP2/Nup358 filaments is essential for protein import and cell viability

RanBP2 captures RanGTP–importin-β complexes at cytoplasmic fibrils to ensure adequate classical NLS–mediated protein import and cell viability

Characterization of Parameters Required for Effective Use of Tamoxifen-Regulated Recombination

Conditional gene targeting using the Cre-loxp system is a well established technique in numerous in vitro and in vivo systems. Ligand regulated forms of Cre have been increasingly used in these applications in order to gain temporal and spatial control over conditional targeting. The tamoxifen-regulated Cre variant mer-Cre-mer (mCrem) is widely utilized because of its reputation for tight regulation in the absence of its tamoxifen ligand. In the DT40 chicken B cell line, we generated an mCrem-based reversible switch for conditional regulation of a transgene, and in contrast with previous work, observed significant constitutive activity of mCrem. This prompted us to use our system for analysis of the parameters governing tamoxifen-regulated mCrem recombination of a genomic target. We find that robust mCrem expression correlates with a high level of tamoxifen-independent Cre activity, while clones expressing mCrem at the limit of western blot detection exhibit extremely tight regulation. We also observe time and dose-dependent effects on mCrem activity which suggest limitations on the use of conditional targeting approaches for applications which require tight temporal coordination of Cre action within a cell population