Human System Engineering Applications from Distracted Driving Simulations

Most of the studies to explore the impact of distracted driving have been descriptive in nature; i.e. the research is conducted in naturalistic settings to evaluate the performance of the driver with and without distracters. However simulation models can also be used that predict the workload for driving tasks. Using concepts from process modeling, baseline models of driving tasks can be created for different driving sequences that include the associated fine motor, visual and cognitive human resources. These models can then be used to evaluate incidents of workload overload caused by different distracters, from both the internal and external vehicle environment. Identifying specific overloaded resources can lead to mitigation strategies to reduce workload and minimize distracted driving. Lessons learned from distracted driving research can then be applied to evaluation other types of manual, visual, and cognitive intensive tasks. Identifying combinations of tasks that contribute to peak workload of operators, and then simulating the impact of multi-tasking using personal devices (i.e. cell phones) can lead to management insights for other types of work environments. Additionally, iterative modeling can also include the impact of sensors and alerts, as well as enhanced workstation displays. Individual component overload can help understand causes for performance detriments during different task sequences, and the impact of additional types of technologies and activities. Using the simulation analysis, the impact on overall workload, identification of peak workload occurrences, and specific overloaded resources can lead to mitigation strategies to reduce workload and improve operator performance

Employee-Task Assignments for Organization Modeling: A Review of Models and Applications

In this study, we present a review of task assignment problems in organizations, an area that has become more important as tasks become more complex and personnel skills become more specialized. The challenge is to design task assignments that meet all requirements and result in the best organizational performance. The consequences of poor design include failed tasks, reduced efficiency, and inability to meet deadlines. Moreover, inequity of workload between employees can cause lack of job satisfaction, loss of motivation and also boredom. In general, work processes in organizations consist of different tasks, which require different expertise. Personnel usually have various degrees of qualifications and their performance may vary for different tasks. The outcome of the work process depends heavily on which tasks are assigned to which personnel. Performance of an organization can be increased by assigning the tasks to the most qualified available personnel. However, it could result in overloading some personnel while the others remain under-loaded. So, the even distribution of the workload between them also needs to be taken into consideration. In addition, it helps to increase organization\u27s productivity by distributing personnel\u27s knowledge, time, and attention more extensively. We review task-employee assignment problems in organization modeling with the computational models that have been reported in the literature with their applications. Human factors engineering, in terms of workload in organizational modeling is included as the work process performance is heavily dependent on the human (personnel). Based on the initial findings, we propose to investigate an improved workload model that allows the use of optimization of select constraints, such as balancing workload among team members. While current workload models allow the evaluation of workload among team members interacting in a work process, it is up to the analyst to suggest improvements. By providing an optimized solution, we present the Engineering Manager, that can then be adjusted to meet practical criteria

Silver Praised, Assailed

Letters to the editor of the Memphis, Tenn. Commercial Appeal regarding James Silver\u27s pro-integration views; one letter is supportive, the rest are critical; Source: Commercial Appeal (Memphis, Tenn.)https://egrove.olemiss.edu/jws_clip/1012/thumbnail.jp

A Heuristic for the Analysis of Truncated Standard Normal Distribution Assemblies

The analysis of data sets and process conditions commonly assume the use of standard normal distributions and truncated standard normal distributions (TSND). The use of these distributions has application to various engineering disciplines along with numerous other industries (e.g., financial industries, medical fields, management, etc.). For engineering managers, the use of truncated standard normal distributions has particular relevance when evaluating process conditions commonly associated with assembly tolerances, manufacturing, and associated measures of quality. This article summarizes a heuristic approach for the analysis of assembly-level truncated standard normal distributions and associated research from a recent dissertation (Ralls, 2014). This article provides a cursory review of the literature presented by that research, briefly reviews key analysis equations, and provides a heuristic procedure from that research. The approach presented summarizes TSND assembly analysis utilizing a distributions characteristic function and an inversion factor for a single doubly truncated standard normal distribution is also reviewed. Applications, research recommendations, and future investigations for engineering managers in the following areas of truncated distribution analysis are proposed: heuristic improvement, distributions expansion, simulation expansion, and further application to storage and part allocations

The Evolution of the Manosphere across the Web

We present a large-scale characterization of the Manosphere, a conglomerate of Web-based misogynist movements focused on men's issues, which has prospered online. Analyzing 28.8M posts from 6 forums and 51 subreddits, we paint a comprehensive picture of its evolution across the Web, showing the links between its different communities over the years. We find that milder and older communities, such as Pick Up Artists and Men's Rights Activists, are giving way to more extreme ones like Incels and Men Going Their Own Way, with a substantial migration of active users. Moreover, our analysis suggests that these newer communities are more toxic and misogynistic than the older ones

Ultrasound-evoked immediate early gene expression in the brainstem of the Chinese torrent frog, Odorrana tormota

The concave-eared torrent frog, Odorrana tormota, has evolved the extraordinary ability to communicate ultrasonically (i.e., using frequencies > 20 kHz), and electrophysiological experiments have demonstrated that neurons in the frog’s midbrain (torus semicircularis) respond to frequencies up to 34 kHz. However, at this time, it is unclear which region(s) of the torus and what other brainstem nuclei are involved in the detection of ultrasound. To gain insight into the anatomical substrate of ultrasound detection, we mapped expression of the activity-dependent gene, egr-1, in the brain in response to a full-spectrum mating call, a filtered, ultrasound-only call, and no sound. We found that the ultrasound-only call elicited egr-1 expression in the superior olivary and principal nucleus of the torus semicircularis. In sampled areas of the principal nucleus, the ultrasound-only call tended to evoke higher egr-1 expression than the full-spectrum call and, in the center of the nucleus, induced significantly higher egr-1 levels than the no-sound control. In the superior olivary nucleus, the full-spectrum and ultrasound-only calls evoked similar levels of expression that were significantly greater than the control, and egr-1 induction in the laminar nucleus showed no evidence of acoustic modulation. These data suggest that the sampled areas of the principal nucleus are among the regions sensitive to ultrasound in this species

Inconsistency in aortic stenosis severity between CT and echocardiography: Prevalence and insights into mechanistic differences using computational fluid dynamics

© 2019 Author(s). Objectives The aims of this study were to evaluate the inconsistency of aortic stenosis (AS) severity between CT aortic valve area (CT-AVA) and echocardiographic Doppler parameters, and to investigate potential underlying mechanisms using computational fluid dynamics (CFD). Methods A total of 450 consecutive eligible patients undergoing transcatheter AV implantation assessment underwent CT cardiac angiography (CTCA) following echocardiography. CT-AVA derived by direct planimetry and echocardiographic parameters were used to assess severity. CFD simulation was performed in 46 CTCA cases to evaluate velocity profiles. Results A CT-AVA>1 cm 2 was present in 23% of patients with echocardiographic peak velocity≥4 m/s (r=-0.33) and in 15% patients with mean Doppler gradient≥40 mm Hg (r=-0.39). Patients with inconsistent severity grading between CT and echocardiography had higher stroke volume index (43 vs 38 mL/m 2, p1 cm 2 in up to a quarter of patients. CFD demonstrates that haemodynamic severity may be exaggerated on Doppler analysis due to high LVOT flow rates, with or without skewed velocity profiles, across the valve orifice. These factors should be considered before making a firm diagnosis of severe AS and evaluation with CT can be helpful

MicroRNAs in pulmonary arterial remodeling

Pulmonary arterial remodeling is a presently irreversible pathologic hallmark of pulmonary arterial hypertension (PAH). This complex disease involves pathogenic dysregulation of all cell types within the small pulmonary arteries contributing to vascular remodeling leading to intimal lesions, resulting in elevated pulmonary vascular resistance and right heart dysfunction. Mutations within the bone morphogenetic protein receptor 2 gene, leading to dysregulated proliferation of pulmonary artery smooth muscle cells, have been identified as being responsible for heritable PAH. Indeed, the disease is characterized by excessive cellular proliferation and resistance to apoptosis of smooth muscle and endothelial cells. Significant gene dysregulation at the transcriptional and signaling level has been identified. MicroRNAs are small non-coding RNA molecules that negatively regulate gene expression and have the ability to target numerous genes, therefore potentially controlling a host of gene regulatory and signaling pathways. The major role of miRNAs in pulmonary arterial remodeling is still relatively unknown although research data is emerging apace. Modulation of miRNAs represents a possible therapeutic target for altering the remodeling phenotype in the pulmonary vasculature. This review will focus on the role of miRNAs in regulating smooth muscle and endothelial cell phenotypes and their influence on pulmonary remodeling in the setting of PAH

Contrasting prefrontal cortex contributions to episodic memory dysfunction in behavioural variant frontotemporal dementia and alzheimer's disease

Recent evidence has questioned the integrity of episodic memory in behavioural variant frontotemporal dementia (bvFTD), where recall performance is impaired to the same extent as in Alzheimer's disease (AD). While these deficits appear to be mediated by divergent patterns of brain atrophy, there is evidence to suggest that certain prefrontal regions are implicated across both patient groups. In this study we sought to further elucidate the dorsolateral (DLPFC) and ventromedial (VMPFC) prefrontal contributions to episodic memory impairment in bvFTD and AD. Performance on episodic memory tasks and neuropsychological measures typically tapping into either DLPFC or VMPFC functions was assessed in 22 bvFTD, 32 AD patients and 35 age- and education-matched controls. Behaviourally, patient groups did not differ on measures of episodic memory recall or DLPFC-mediated executive functions. BvFTD patients were significantly more impaired on measures of VMPFC-mediated executive functions. Composite measures of the recall, DLPFC and VMPFC task scores were covaried against the T1 MRI scans of all participants to identify regions of atrophy correlating with performance on these tasks. Imaging analysis showed that impaired recall performance is associated with divergent patterns of PFC atrophy in bvFTD and AD. Whereas in bvFTD, PFC atrophy covariates for recall encompassed both DLPFC and VMPFC regions, only the DLPFC was implicated in AD. Our results suggest that episodic memory deficits in bvFTD and AD are underpinned by divergent prefrontal mechanisms. Moreover, we argue that these differences are not adequately captured by existing neuropsychological measures