the antiangiogenic therapy in ovarian cancer

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Dynamic crosstalk within the tumor microenvironment of uterine cervical carcinoma: baseline network, iatrogenic alterations, and translational implications.

Uterine cervical cancer is the fourth most frequent gynecological tumor worldwide. The tumor microenvironment of cervical cancer is the result of persistent high-risk human papillomavirus infection together with stromal activation of estrogen receptor alpha and the pro-angiogenic and pro-inflammatory activity of immune cells, mainly T-helper 17 cells and tumor-associated macrophages. Therapeutic management (e.g., immunotherapy, especially in advanced cases) may be influenced by the translational implications of tumoral stroma crosstalk and an abundance of tumor-infiltrating lymphocytes within the tumor microenvironment. The prognosis of cervical cancer is inversely correlated with microvessel density, making anti-angiogenic strategies with agents such as bevacizumab crucial for improving both progression-free survival and overall survival in patients with advanced and recurrent tumors

Peritoneal Tuberculosis Mimicking Ovarian Cancer: Gynecologic Ultrasound Evaluation with Histopathological Confirmation

Peritoneal tuberculosis (TBP) is a very rare condition, accounting for about 1–2% of all tuberculosis cases. The diagnosis of TBP can be easily mistaken for advanced ovarian cancer (AOC) or peritoneal carcinoma because of overlapping laboratory and clinical findings. We reported the ultrasound characteristics of a case of TBP in a 67-year-old woman who presented to our institute with a 1-month history of intermittent lower abdominal pain, fever, and asthenia. Overall, 20 biopsy-retrieved specimen histopathological features were suggestive of peritoneal tuberculosis. Gynecologic ultrasound revealed increased adnexa with multiple nodular formations spread across the surface, suggestive of caseous nodules. Although this is a rare occurrence, clinicians should consider TBP as a differential diagnosis of ovarian or peritoneal cancer

Skin Mycetoma in an 11-Year-Old African Boy: Case Presentation with Emphasis on Histopathological Features and Differential Diagnosis

Mycetoma is an uncommon, chronic infective disease of the skin and subcutaneous tissues, characterized by the triad of tumefaction, draining sinuses, and the presence in the exudate of colonial grains. In cases of long-term disease, the presence of colonial grains together with the host's derivative material can lead to the formation of real sinuses. Histological analysis is of fundamental importance to allow an accurate etiological diagnosis and to understand if the basic pathogen is an actinomycete (bacterium) or a real fungus (eumycetic mycetomas) and is also fundamental for therapy, which is quite different. Here, we present a case of Mycetoma in an 11-year-old patient who emigrated from Djibouti, Somalia, and showed the essential histopathological features of this rare and forgotten nosographic entity in the industrialized world and briefly discuss the major and most important differential diagnoses

Robotic Lateral Pelvic Organ Prolapse Suspension of Multicompartment Vaginal Prolapse

Objective Sacrocolpopexy is associated with rare but serious morbidity. The technique was progressively modified.[1,2,3] The goal of our video is to highlight the robotic technique in a multicompartment prolapse of vaginal vault with lateral suspension. The patient was a 58-year-old female with multicompartment pelvic organ prolapse arose after hysterectomy. Go to: Design We further developed this technique with the da Vinci system which allowed us to avoid the transparietal passage of the mesh, avoiding potential damage to the ilioinguinal and iliohypogastric nerves. There was no standardized procedure.[4,5,6,7,8] Informed consent was obtained. Go to: Setting Manzoni Hospital, third referral center. All the crucial steps of our surgical approach were visualized. Position of the patient was described in our previous paper.[9,10] After introducing the da Vinci 0° optic, we placed the two 8-mm trocars in each iliac fossa, laterally about 5 cm above and 2 cm medial to the anterior superior iliac spine. Go to: Interventions The procedure uses a titanized propylene prosthesis shaped in T that gives it maneuverability and elasticity proper to native tissues. The positioning technique involves a first phase of removing peritoneum from the vaginal dome and then the disconnect of the vescicovaginal band to delimit the mesh anchoring plans. The lateral trajectory of it consists to insert in a retrograde manner the side arm of the prothesis in the context of the lateral abdominal wall with a posterior projection to the anterior-upper iliac crest in a space which is free of major complications [Figures ​[Figures11 and ​and2].2]. Procedure started with dissection of the cervicovesical pouch. The vesicovaginal space was then identified between the bladder and the anterior vaginal wall. A mesh (Endolas® 41.5 cm × 5 cm × 15 cm) with two lateral arms was tailored and fixed to the vagina, by six sutures of 2-0 polyglactin 910. The peritoneum of the vesicouterine fold was closed over the mesh

Dedifferentiated Melanoma: A Diagnostic Histological Pitfall! Review of the Literature with Case Presentation

Dedifferentiated melanoma is a particular form of malignant melanoma with a progressive worsening of the patient's clinical outcome. It is well known that melanoma can assume different histo-morphological patterns, to which specific genetic signatures correspond, sometimes but not always. In this review we address the diagnostic difficulties in correctly recognizing this entity, discuss the major differential diagnoses of interest to the dermatopathologist, and conduct a review of the literature with particular attention and emphasis on the latest molecular discoveries regarding the dedifferentiation/undifferentiation mechanism and more advanced therapeutic approaches

2022-RA-767-ESGO Machine learning to implement the accuracy of magnetic resonance imaging (MRI) in the detection of lymph node metastasis in patients with locally advance cervical cancer treated with neoadjuvant chemotherapy

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