1,935 research outputs found
Wavelet Analysis and Denoising: New Tools for Economists
This paper surveys the techniques of wavelets analysis and the associated methods of denoising. The Discrete Wavelet Transform and its undecimated version, the Maximum Overlapping Discrete Wavelet Transform, are described. The methods of wavelets analysis can be used to show how the frequency content of the data varies with time. This allows us to pinpoint in time such events as major structural breaks. The sparse nature of the wavelets representation also facilitates the process of noise reduction by nonlinear wavelet shrinkage , which can be used to reveal the underlying trends in economic data. An application of these techniques to the UK real GDP (1873-2001) is described. The purpose of the analysis is to reveal the true structure of the data - including its local irregularities and abrupt changes - and the results are surprising.Wavelets, Denoising, Structural breaks, Trend estimation
Comparative Economic Cycles
The income cycles that have been experienced by six OECD countries over the past 24 years are analysed. The amplitude of the cycles relative to the level of aggregate income varies amongst the countries, as does the degree of the damping that affects the cycles. The study aims to reveal both of these characteristics. It also seeks to determine whether there exists a clear relationship between the degree of damping and the length of the cycles. In order to estimate the parameters of the cycles, the data have been subjected to the processes of detrending, anti-alias filtering and subsampling.Business cycles, Autoregressive models
Sustainable Development Policies in Europe
The objective of this paper is to investigate the actual situation in the shift towards the implementation of Sustainable Development Policies in Europe. The aim is to highlight the key role of the European Union in bringing about sustainable development within Europe and also on the wider global stage. It will show how the European Commission performs its commitment in reaching a sustainable regulation by issuing some documents and declarations. The paper frames the EU action into an international framework of strategies, agreements and policies on SD and, at the same time, provides an overview on experiences of SD strategy implementations at the national level, according to the commission pressing on MS to produce their own SD strategy and implement it. Indicators systems, issues of interest and fields of actions are compared: the analysis of these elements aims to highlight common scenarios of SD strategies that reveal the trends towards a more sustainable growth in the European Union.Sustainable Development, Globalization, Environment Policy, Strategy for Sustainable Development, Good Governance, Participation
Orthogonality Conditions for Non-Dyadic Wavelet Analysis
The conventional dyadic multiresolution analysis constructs a succession of frequency intervals in the form of ( π / 2 j , π / 2 j - 1 ); j = 1, 2, . . . , n of which the bandwidths are halved repeatedly in the descent from high frequencies to low frequencies. Whereas this scheme provides an excellent framework for encoding and transmitting signals with a high degree of data compression, it is less appropriate to the purposes of statistical data analysis. A non-dyadic mixed-radix wavelet analysis is described that allows the wave bands to be defined more flexibly than in the case of a conventional dyadic analysis. The wavelets that form the basis vectors for the wave bands are derived from the Fourier transforms of a variety of functions that specify the frequency responses of the filters corresponding to the sequences of wavelet coefficients.Wavelets, Non-dyadic analysis, Fourier analysis
Testing for Contagion: a Time-Scale Decomposition
The aim of the paper is to test for ¯nancial contagion by estimating a simultaneous equation model subject to structural breaks. For this purpose, we use the Maximum Overlapping Discrete Wavelet Transform, MODWT, to decompose the covariance matrix of four asset returns on a scale by scale basis. This decomposition will enable us to identify the structural form model and to test for spillover e®ects between country speci¯c shocks during a crisis period. We distinguish between the case of the structural form model with a single dummy and the one with multiple dummies capturing shifts in the co-movement of asset returns occurring during periods of ¯nancial turmoil. The empirical results for four East Asian emerging stock markets show that, once we account for interdependence through an (unobservable) common factor, there is hardly any evidence of contagion during the 1997-1998 financial turbulence.wavelets; simultaneous equations model; financial contagion
Pasado y futuro en un presente convulso : dos revistas económicas catalanas ante la Gran Guerra
El presente artículo pretende analizar la lectura que hicieron dos importantes publicaciones económicas catalanas de los acontecimientos europeos entre 1914 y 1919. El intento es acercarse a la visión que sectores importantes de la clase dirigente del país -que, a la vez, producían y eran receptoras de dichas publicaciones- tuvieron del cambio de época representado por la Gran Guerra. Por ello, y más allá del debate general que recorrió también Catalunya en torno a las dos alianzas en lucha, el objeto principal será la capacidad de comprensión de los cambios sociales, económicos, políticos y culturales producidos por la confrontación militar más devastadora que el mundo conoció hasta aquel momento, tanto a nivel internacional como a nivel interno. Esta contribución focalizará especialmente la manera en que estas revistas recogieron y analizaron el debate sobre los tratados de paz y la reestructuración monetaria, considerando este último aspecto un indicador importante de la capacidad de análisis e interiorización de los cambios acaecidos en términos de relaciones de fuerza en el escenario internacional y más en general en las relaciones entre capital y trabajo.El present article pretén analitzar la lectura que van fer dues importants publicacions econòmiques catalanes dels esdeveniments europeus entre 1914 i 1919. L'intent és acostar-se a la visió que sectors importants de la classe dirigent del país -que, alhora, produïen i eren receptores d'aquestes publicacions- van tenir del canvi d'època representat per la Gran Guerra. Per això, i més enllà del debat general que va recórrer també Catalunya al voltant de les dues aliances en lluita, l'objecte principal serà la capacitat de comprensió dels canvis socials, econòmics, polítics i culturals produïts per la confrontació militar més devastadora que el món va conèixer fins a aquell moment, tant a nivell internacional com a nivell intern. Aquesta contribució se centrarà especialment en la manera com aquestes revistes van recollir i van analitzar el debat sobre els tractats de pau i la reestructuració monetària, tot considerant aquest últim aspecte com un indicador important de la capacitat d'anàlisi i interiorització dels canvis esdevinguts en termes de relacions de força en l'escenari internacional i més en general en les relacions entre capital i treball.This article aims to analyze how two important catalan economic magazines read the events between 1914 and 1919. The core issue is to approach the vision that important sectors of the country's ruling class -both producing and receiving such publications- had about the epocale change represented by the Great War. Therefore, beyond the general debate around the two alliances fighting, the main focus will be catching the ability to understand social, economic, political and cultural change produced by the most devastating military conflict until then. This contribution will analize especially how these magazines collected and analyzed the debate about peace treaties and currency restructuring, considering this last element as an important indicator of the ability to analyze and internalize the changes in terms of power relations in international stage and more generally in the relations between capital and work
Pasado y futuro en un presente convulso: dos revistas económicas catalanas ante de la Gran Guerra
El present article pretén analitzar la lectura que van fer dues importants publicacions econòmiques catalanes dels esdeveniments europeus entre 1914 i 1919. L'intent és acostar-se a la visió que sectors importants de la classe dirigent del país –que, alhora, produïen i eren receptores d'aquestes publicacions– van tenir del canvi d'època representat per la Gran Guerra. Per això, i més enllà del debat general que va recórrer també Catalunya al voltant de les dues aliances en lluita, l'objecte principal serà la capacitat de comprensió dels canvis socials, econòmics, polítics i culturals produïts per la confrontació militar més devastadora que el món va conèixer fins a aquell moment, tant a nivell internacional com a nivell intern. Aquesta contribució se centrarà especialment en la manera com aquestes revistes van recollir i van analitzar el debat sobre els tractats de pau i la reestructuració monetària, tot considerant aquest últim aspecte com un indicador important de la capacitat d'anàlisi i interiorització dels canvis esdevinguts en termes de relacions de força en l'escenari internacional i més en general en les relacions entre capital i treball.This article aims to analyze how two important catalan economic magazines read the events between 1914 and 1919. The core issue is to approach the vision that important sectors of the country's ruling class -both producing and receiving such publications- had about the epocale change represented by the Great War. Therefore, beyond the general debate around the two alliances fighting, the main focus will be catching the ability to understand social, economic, political and cultural change produced by the most devastating military conflict until then. This contribution will analize especially how these magazines collected and analyzed the debate about peace treaties and currency restructuring, considering this last element as an important indicator of the ability to analyze and internalize the changes in terms of power relations in international stage and more generally in the relations between capital and work.El presente artículo pretende analizar la lectura que hicieron dos importantes publicaciones económicas catalanas de los acontecimientos europeos entre 1914 y 1919. El intento es acercarse a la visión que sectores importantes de la clase dirigente del país –que, a la vez, producían y eran receptoras de dichas publicaciones– tuvieron del cambio de época representado por la Gran Guerra. Por ello, y más allá del debate general que recorrió también Catalunya en torno a las dos alianzas en lucha, el objeto principal será la capacidad de comprensión de los cambios sociales, económicos, políticos y culturales producidos por la confrontación militar más devastadora que el mundo conoció hasta aquel momento, tanto a nivel internacional como a nivel interno. Esta contribución focalizará especialmente la manera en que estas revistas recogieron y analizaron el debate sobre los tratados de paz y la reestructuración monetaria, considerando este último aspecto un indicador importante de la capacidad de análisis e interiorización de los cambios acaecidos en términos de relaciones de fuerza en el escenario internacional y más en general en las relaciones entre capital y trabajo
Energy management and guidelines to digitalisation of integrated natural gas distribution systems equipped with expander technology
In a swirling dynamic interaction, digital innovation, environment and
anthropological evolution are swiftly shaping the smart grid scenario. Integration
and flexibility are the keywords in this emergent picture characterised by a low
carbon footprint. Digitalisation, within the natural limits imposed by the
thermodynamics, seems to offer excellent opportunities for these purposes. Of
course, here starts a new challenge: how digital technologies should be employed
to achieve these objectives? How would we ensure a digital retrofit does not lead to
a carbon emission increase? In author opinion, as long as it remains a generalised
question, none answer exists: the need to contextualise the issue emerges from the
variety of the characteristics of the energy systems and from their interactions with
external processes. To address these points, in the first part of this research, the
author presented a collection of his research contributions to the topic related to the
energy management in natural gas pressure reduction station equipped with turbo
expander technology. Furthermore, starting from the state of the art and the author's
previous research contributions, the guidelines for the digital retrofit for a specific
kind of distributed energy system, were outlined. Finally, a possible configuration
of the ideal ICT architecture is extracted. This aims to achieve a higher level of
coordination involving, natural gas distribution and transportation, local energy
production, thermal user integration and electric vehicles charging. Finally, the
barriers and the risks of a digitalisation process are critically analysed outlining in
this way future research needs
In vivo assessment of class-specific inducible inhibitors of metalloproteinases in osteoarthritis
The role of articular cartilage is providing a painless and attrition-free surface for
joints movements. Osteoarthritis (OA) is a debilitating multifactorial pathology
characterized by progressive articular cartilage loss, exposition of the bone
surface accompanied by pain, and final loss of joint functions. To date there is
not an effective alternative to surgical replacement of damaged joints.
Metalloproteinases (MPs) play an important role in cartilage remodelling both in
physiological and pathological conditions. Among the metalloproteinases, the
aggrecanase family was shown to be the major family responsible for aggrecan
breakdown, while matrix metalloproteinases (MMPs) target preferentially the
collagen molecules. Tissue inhibitor of metalloproteinases (TIMPs) are the
endogenous regulators of those enzymes and in particular TIMP-3 was found to
possess the broadest activity. So far all synthetic MP inhibitors failed in trials for
OA treatment, and TIMP-3 may prove to be a possible alternative. Notably
several synthetic mutants were generated to restrict its activity towards
metalloproteinases.
In order to test the potential therapeutic effects of these proteins, I decided to
employ transgenic overexpressing mice. However I appreciated that it is of
paramount importance to restrict the exogenous expression just to cartilage.
Moreover because it was previously observed that overexpression of TIMP-3 in
cartilage severely affects bone development and caused embryonic lethality, I
decided to generate tissue specific inducible transgenic mice. I focused on the
Aggrecan promoter in order to achieve specific cartilage expression and the
Cre/loxP system to obtain inducible expression.
Here I show the design and generation of a new aggrecan-driven Cre deleter
mouse line. These mice can effectively target floxed genes in cartilage. I also
show the generation of inducible TIMP-expressing mouse lines for both a
cartilage-specific and ubiquitous expression.
I aim to induce OA in those transgenic mice, after induction of TIMPs
expression, to evaluate the inhibitors role in OA treatment.Open Acces
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