8,852 research outputs found

    Finding Common Ground to Treat Primary and Metastatic Cancer: The Potential of Targeting Tumor Stroma

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    Primary carcinomas and metastases are complex organ-like structures composed of malignant parenchymal epithelial tissues and a desmoplastic stroma formed by accumulation of hematopoietic cells, mesenchymal stromal cells and extracellular matrix. The crosstalk between malignant epithelial cells and tumor stroma is becoming increasingly appreciated as a key determinant in tumor development, progression and metastasis, as well as inducing resistance to various cancer treatments including chemotherapy, radiotherapy and immunotherapy. Mechanistic understanding of how the tumor-stromal interaction contributes to tumor progression and therapeutic resistance will advance cancer therapies and improve clinical management, especially for patients with metastatic disease. Fibroblast activation protein (FAP) is a membrane surface protease found overexpressed in cancer-associated stromal cells. Overexpression of FAP is associated with tumor progression, metastasis and recurrence, and predicts a poorer prognosis in many types of human tumors. The central goal of my thesis project is to investigate whether FAP protease and/or FAP protease-expressing stromal cells play essential roles in tumor progression and metastasis. In collaboration with Drs. Steven Albelda and Carl Juneā€™s groups, we generated chimeric antigen receptor (CAR) T cells redirected against FAP+ stromal cells to study their impact on tumor progression. Conditional depletion of FAP+ stromal cells by FAP-CAR T cells restrains tumor progression without causing severe toxicity. Mechanistic investigations revealed that FAP+ stromal cells promote tumor growth via immune suppression and immune-independent remodeling of the stromal microenvironment. Additionally, using FAP-deficient mice, I found that FAP protease promotes early malignant cell seeding and pulmonary metastatic outgrowth, possibly through regulating coagulation pathways and the inflammatory response, respectively. Finally, I observed that FAP protease promotes pancreatic cancer development, as its deletion delays the progression of preneoplastic lesions and tumor formation in a genetically engineered mouse model of pancreatic ductal carcinoma. FAP protease is also essential for inducing pancreatic cancer resistance to necrotic cell death and promoting metastasis and outgrowth in multiple target organs. Together, these findings demonstrate that molecular and cellular targeting of FAP represents a promising therapeutic approach for a variety of solid tumors

    On the Design of Perceptual MPEG-Video Encryption Algorithms

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    In this paper, some existing perceptual encryption algorithms of MPEG videos are reviewed and some problems, especially security defects of two recently proposed MPEG-video perceptual encryption schemes, are pointed out. Then, a simpler and more effective design is suggested, which selectively encrypts fixed-length codewords (FLC) in MPEG-video bitstreams under the control of three perceptibility factors. The proposed design is actually an encryption configuration that can work with any stream cipher or block cipher. Compared with the previously-proposed schemes, the new design provides more useful features, such as strict size-preservation, on-the-fly encryption and multiple perceptibility, which make it possible to support more applications with different requirements. In addition, four different measures are suggested to provide better security against known/chosen-plaintext attacks.Comment: 10 pages, 5 figures, IEEEtran.cl

    Cognitive behavioral therapy for the management of multiple sclerosisā€“related pain: a randomized clinical trial

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    BACKGROUND: Pain is a common and often debilitating symptom among persons with multiple sclerosis (PwMS). Besides interfering with daily functioning, pain in MS is associated with higher levels of depression and anxiety. While cognitive-behavioral therapy (CBT) for pain has been found to be an effective treatment in other populations, there has been a dearth of research in PwMS. METHODS: PwMS with at least moderate pain severity (N = 20) were randomly assigned to one of two groups: CBT plus standard care (CBT/SC) or MS-related education plus standard care (ED/SC), each of which met for 12 sessions. Changes in pain severity, pain interference, and depressive symptom severity from baseline to the 15 week follow-up were assessed using a 2Ɨ2 factorial design. Participants also rated their satisfaction with their treatment and accomplishment of personally meaningful behavioral goals. RESULTS: Both treatment groups rated their treatment satisfaction as very high and their behavioral goals as largely met, although only the CBT/SC group's mean goal accomplishment ratings represented significant improvement. While there were no significant differences between groups post-treatment on the three primary outcomes, there was an overall improvement over time for pain severity, pain interference, and depressive symptom severity. CONCLUSIONS: CBT or education-based programs may be helpful adjunctive treatments for PwMS experiencing pain.Accepted manuscrip

    Implementation of 5S in Improving of Palm Oil Mill Working Environment

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    A work environment describes a place for employees affect them to do their tasks. A good work environment will certainly make employees do and spend all their energy and mind to work optimally. A comfortable feeling of the work environment can reduce boredom at work. This comfort feelings have an impact on increasing motivation and producing employee job satisfaction. The condition of the working environment in palm oil industry is currently classified as messy where there are still some tools scattered on the factory floor, there is mud and slippery puddles in various places such as floors or stairs. Conditions like this certainly need to be repaired immediately to avoid the risk of work accidents and increase employees' comfortable. Improvement of working environment conditions can be done by various methods, one of the methods is 5S method. 5S spelling as (Seiri, Seiton, Seiso, Seiketsu, Shitsuke) is one of the effective tool in management to improve the work culture of workers and the conditions of the work environment in a factory. Based on the evaluation results, the evaluation categories of 5S implementations are Seiri of 16 score, Seiton of 16 score, Seiso of 9 score, Seiketsu of 8 score, Shitsuke of 7 score. The results of this total score show the 5S value of palm oil mill is in the average score of 56 total score
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