Climate change and individual behavior : considerations for policy

Climate change is anthropogenic - the product of billions of acts of daily consumption. That solutions need to be anthropogenic too is well accepted. Yet, suggested solutions are normally cast in the realms of finance and technology, often neglecting the primal root of the problem: individual behavior. An emerging body of social-psychology scholarship has examined the barriers and drivers of individual behavior in relation to both adaptation and mitigation. This paper reviews some of its conclusions, and suggests policy areas that should be considered in devising appropriate interventions.Environmental Economics&Policies,Climate Change,Transport and Environment,Energy Production and Transportation,Environment and Energy Efficiency

Civil society in a weak state: The political functions of associational life in Algeria 1987-2005.

This study analyses the significance of Algeria's associative sphere in the context of the state's attempts to retain legitimacy. Starting from a critique of portrayals of Algerian 'civil society' as a force conducive to democratization, and by framing the period under study in a broader historical perspective, the thesis examines the changing relationship of the state to voluntary associations in both the colonial and post-colonial eras. It considers the place of associational life in the political economy of economic reform, investigating the role it played in facilitating the state's retreat from service provision. Consideration of the notion that civic associations shape people's propensity towards cooperation and collective action, facilitating democratic politics through the injection of trust and social capital, provides the starting point for analyzing their internal dynamics and the incentives driving their functioning. A further examination of the social bases of the associative sphere then leads to questioning its independence from the state, and highlights the role of the associative sector in tempering the fracture between the state and those social groups that most suffered from the collapse of Algeria's post colonial political framework. A critical examination of the proposition that civil society organisations legitimate and strengthen representative political institutions such as parties and parliament provides the opportunity to show how the associative sphere contributed to preserving the dominance of the executive in the political system despite the introduction of multi-partism. Finally, the study analyses donors' use of advocacy and service-delivery associations in democracy-promotion programmes, arguing that their focus on the country's 'civil society' contributed to the state's efforts to preserve its international legitimacy. In this light, rather than a driver of democratic change, the associative sphere appears as one of the elements of conservation used by a weakened state to reacquire legitimacy and reinforce its capacity to secure voluntary acquiescence in its rule

Climate Change and Migration in the MENA Region: An Overview

Climate change and migration are major concerns in the MENA region, yet the empirical evidence on the impact of climate change and extreme weather events on migration remains limited. Information is broadly lacking on how households in vulnerable areas perceive changes in the climate, how they are affected by extreme weather events, whether they benefit from community and government programs to help them cope with and adapt to a changing climate, and how these conditions influence the decision of household members to migrate, either temporarily or permanently. This introductory chapter summarizes briefly the main results of the study which relied on existing data as well as focus groups and new household surveys collected in 2011 in Algeria, Egypt, Morocco, Syria, and Yemen. The results suggest that households do perceive important changes in the climate, and that many households are being affected by extreme weather events resulting in losses in income, crops, and livestock. The coping and adaptation strategies used by households to deal with weather shocks are diverse, but also limited, with most households not able to recover from the negative impact of weather shocks. The ability of community level responses and government programs to support households is also very limited. Finally, while climate change is not today the main driver of migration flows, it does appear to contribute to these flows, and worsening climatic conditions are likely to exacerbate future migration flows

Is Climate Change Likely to Lead to Higher Net Internal Migration? The Republic of Yemen’s Case

Concerns abound about the potential impact of climate change on future migration, especially in the Middle East and North Africa, one of the regions that is likely to suffer the most from climate change. Yet it is not clear whether so far climate patterns have been a key driver of internal migration in countries such as Yemen, despite the pressures created by water scarcity. By combining data from Yemen’s latest census and a weather database as well as other geographic information, we analyze the determinants of past net internal migration rates. Next, using future climate change scenarios, we predict the potential impact of rising temperatures on future net internal migration rates. The results suggest that while climate does have an impact on net internal migration rates, this impact is limited, so that on the basis of past patterns of climate and migration, rising temperature may not have a large impact on future net internal migration

Dark current spectroscopy of transition metals in CMOS image sensors

We have investigated the effects of deliberate heavymetals contamination on dark current and image defects in CMOS Image Sensors (CIS). Analysis of dark current in these imager dice has revealed different behaviors among most important 3d metals present in the process line. We have implanted directly in 3 Mega array pixels the following metals: Cr, V, Cu, Ni, Fe, Ti, Mo, W, Al and Zn. Analyzing the dark current "spectrum" as obtained for fixed integration periods of time by means of standard image-Testing equipment, these impurities can be identified and detected with a sensitivity of ∼ 109 traps/cm3 or higher

Social economic costs, health-related quality of life and disability in patients with Cri Du Chat syndrome

Cri du Chat syndrome (CdC) is a rare disease. The aim is to estimate economic costs related to CdC from a societal perspective, to assess the QoL and Disability in patients with CdC along with their caregivers in Italy

Children and adults affected by Cri du Chat syndrome: Care's recommendations

Our objective is to collect data and information for a better care and follow up in Cri du Chat patients. We conducted a literature review in August 2017 and then discuss the outcomes within the ABC (Associazione Bambini Cri du Chat, Italian CdC families support group). A proposal for clinical, laboratory and imaging work up should be performed at various ages in CdC patients. Follow up and rehabilitation should continue lifelong as some improvements can be obtained also in older ages and not to lose acquired skills

Colorectal surgery in Italy during the Covid19 outbreak: a survey from the iCral study group

Background The COVID19 pandemic had a deep impact on healthcare facilities in Italy, with profound reorganization of surgical activities. The Italian ColoRectal Anastomotic Leakage (iCral) study group collecting 43 Italian surgical centers experienced in colorectal surgery from multiple regions performed a quick survey to make a snapshot of the current situation. Methods A 25-items questionnaire was sent to the 43 principal investigators of the iCral study group, with questions regard- ing qualitative and quantitative aspects of the surgical activity before and after the COVID19 outbreak. Results Two-thirds of the centers were involved in the treatment of COVID19 cases. Intensive care units (ICU) beds were partially or totally reallocated for the treatment of COVID19 cases in 72% of the hospitals. Elective colorectal surgery for malignancy was stopped or delayed in nearly 30% of the centers, with less than 20% of them still scheduling elective colo- rectal resections for frail and comorbid patients needing postoperative ICU care. A significant reduction of the number of colorectal resections during the time span from January to March 2020 was recorded, with significant delay in treatment in more than 50% of the centers. Discussion Our survey confirms that COVID19 outbreak is severely affecting the activity of colorectal surgery centers partici- pating to iCral study group. This could impact the activity of surgical centers for many months after the end of the emergency

Prognostic and Predictive Role of Body Composition in Metastatic Neuroendocrine Tumor Patients Treated with Everolimus: A Real-World Data Analysis

Neuroendocrine tumors (NETs) are rare neoplasms frequently characterized by an up- regulation of the mammalian rapamycin targeting (mTOR) pathway resulting in uncontrolled cell proliferation. The mTOR pathway is also involved in skeletal muscle protein synthesis and in adipose tissue metabolism. Everolimus inhibits the mTOR pathway, resulting in blockade of cell growth and tumor progression. The aim of this study is to investigate the role of body composition in- dexes in patients with metastatic NETs treated with everolimus. The study population included 30 patients with well-differentiated (G1-G2), metastatic NETs treated with everolimus at the IRCCS Romagnolo Institute for the Study of Tumors (IRST) “Dino Amadori”, Meldola (FC), Italy. The body composition indexes (skeletal muscle index [SMI] and adipose tissue indexes) were assessed by measuring on a computed tomography (CT) scan the cross-sectional area at L3 at baseline and at the first radiological assessment after the start of treatment. The body mass index (BMI) was assessed at baseline. The median progression-free survival (PFS) was 8.9 months (95% confidence interval [CI]: 3.4–13.7 months). The PFS stratified by tertiles was 3.2 months (95% CI: 0.9–10.1 months) in patients with low SMI (tertile 1), 14.2 months (95% CI: 2.3 months-not estimable [NE]) in patients with intermediate SMI (tertile 2), and 9.1 months (95% CI: 2.7 months-NE) in patients with high SMI (tertile 3) (p = 0.039). Similarly, the other body composition indexes also showed a statistically significant difference in the three groups on the basis of tertiles. The median PFS was 3.2 months (95% CI: 0.9–6.7 months) in underweight patients (BMI 18.49 kg/m2) and 10.1 months (95% CI: 3.7–28.4 months) in normal-weight patients (p = 0.011). There were no significant differences in terms of overall survival. The study showed a correlation between PFS and the body composition indexes in patients with NETs treated with everolimus, underlining the role of adipose and muscle tissue in these patients

Orthogonal Proteogenomic Analysis Identifies the Druggable PA2G4-MYC Axis in 3q26 AML

The overexpression of the ecotropic viral integration site-1 gene (EVI1/MECOM) marks the most lethal acute myeloid leukemia (AML) subgroup carrying chromosome 3q26 abnormalities. By taking advantage of the intersectionality of high-throughput cell-based and gene expression screens selective and pan-histone deacetylase inhibitors (HDACis) emerge as potent repressors of EVI1. To understand the mechanism driving on-target anti-leukemia activity of this compound class, here we dissect the expression dynamics of the bone marrow leukemia cells of patients treated with HDACi and reconstitute the EVI1 chromatin-associated co-transcriptional complex merging on the role of proliferation-associated 2G4 (PA2G4) protein. PA2G4 overexpression rescues AML cells from the inhibitory effects of HDACis, while genetic and small molecule inhibition of PA2G4 abrogates EVI1 in 3q26 AML cells, including in patient-derived leukemia xenografts. This study positions PA2G4 at the crosstalk of the EVI1 leukemogenic signal for developing new therapeutics and urges the use of HDACis-based combination therapies in patients with 3q26 AML